Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications, Nagar Swati, Argikar Upendra A., Tweedie Donald

Автор: Alejandro C Olivieri
Название: Fundamentals and Analytical Applications of Multi-way Calibration
ISBN: 0444635270 ISBN-13(EAN): 9780444635273
Издательство: Elsevier Science
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Fundamentals and Analytical Applications of Multi-Way Calibration presents researchers with a set of effective tools they can use to obtain the maximum information from instrumental data. It includes the most advanced techniques, methods, and algorithms related to multi-way calibration and the ways they can be applied to solve actual analytical problems.

Автор: Deen
Название: Optical Communication Systems: Fundamentals and Applications
ISBN: 0470518677 ISBN-13(EAN): 9780470518670
Издательство: Wiley
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Цена: 12347.00 р.
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Описание: Fiber-optic communication systems have advanced dramatically over the last four decades, since the era of copper cables, resulting in low-cost and high-bandwidth transmission. Fiber optics is now the backbone of the internet and long-distance telecommunication.

Автор: Reed, Roger C.
Название: The Superalloys (Fundamentals and Applications)
ISBN: 0521070112 ISBN-13(EAN): 9780521070119
Издательство: Cambridge Academ
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Цена: 8870.00 р.
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Описание: Superalloys are unique high-temperature materials used in gas turbine engines, which display excellent resistance to mechanical and chemical degradation. This book introduces the metallurgical principles which have guided their development. Suitable for graduate students and researchers, it includes exercises and additional resources at www.cambridge.org/9780521859042.

Автор: Nayfeh, Munir
Название: Fundamentals and Applications of Nano Silicon in Plasmonics and Fullerines
ISBN: 0323480578 ISBN-13(EAN): 9780323480574
Издательство: Elsevier Science
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Описание: Fundamentals and Applications of Nano Silicon in Plasmonics and Fullerines: Current and Future Trends addresses current and future trends in the application and commercialization of nanosilicon. The book presents current, innovative and prospective applications and products based on nanosilicon and their binary system in the fields of energy harvesting and storage, lighting (solar cells and nano-capacitor and fuel cell devices and nanoLEDs), electronics (nanotransistors and nanomemory, quantum computing, photodetectors for space applications; biomedicine (substance detection, plasmonic treatment of disease, skin and hair care, implantable glucose sensor, capsules for drug delivery and underground water and oil exploration), and art (glass and pottery). . Moreover, the book includes material on the use of advanced laser and proximal probes for imaging and manipulation of nanoparticles and atoms. In addition, coverage is given to carbon and how it contrasts and integrates with silicon with additional related applications. This is a valuable resource to all those seeking to learn more about the commercialization of nanosilicon, and to researchers wanting to learn more about emerging nanosilicon applications.

Автор: Juergen Siepmann; Ronald A. Siegel; Michael J. Rat
Название: Fundamentals and Applications of Controlled Release Drug Delivery
ISBN: 1489986464 ISBN-13(EAN): 9781489986467
Издательство: Springer
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Описание: This book approaches the subject from a mechanistic perspective that pitches the language at a level that is understandable to those entering the field and who are not familiar with its common phrases or complex terms.

Название: Enzyme kinetics in drug metabolism
ISBN: 1627037578 ISBN-13(EAN): 9781627037570
Издательство: Springer
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Цена: 30745.00 р.
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Описание:

1. Enzyme Kinetics in Drug Metabolism - Fundamentals and Applications

Swati Nagar, Upendra A. Argikar, and Donald J. Tweedie

Part I. Fundamentals of Enzyme Kinetics

2. Fundaments of Enzyme Kinetics

Eleanore Seibert and Timothy S. Tracy

3. Different Enzyme Kinetic Models

Eleanore Seibert and Timothy S. Tracy

4. Reversible Mechanisms of Enzyme Inhibitors and Resulting Clinical Significance

Barbara Ring, Steven A. Wrighton, and Michael Mohutsky

5. Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions

Michael Mohutsky and Stephen D. Hall

6. Multi-Enzyme Kinetics and Sequential Metabolism

Larry C. Wienkers and Brooke VandenBrink

7. Consideration of the Unbound Drug Concentration in Enzyme Kinetics

Nigel J. Waters, R. Scott Obach, and Li Di

Part II. Kinetics of Drug Metabolizing Enzymes and Transporters

8. Enzyme Kinetics of Oxidative Metabolism - Cytochromes P450

Ken Korzekwa

9. Enzyme Kinetics, Pharmacokinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase

John T. Barr, Kanika Choughule, and Jeffrey P. Jones

10. Enzyme Kinetics of Conjugative Enzymes - PAPS

Margaret O. James

11. Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)

Jin Zhou and John Miners

12. Principles and Experimental Considerations for in vitro Transporter Interaction Assays

Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Wiskercher, and Ismael J. Hidalgo

Part III. Modeling Considerations

13. Rationalising Under-Prediction of Drug Clearance from Enzyme and Transporter Kinetic Data - from in vitro Tools to Mechanistic Modeling

Aleksandra Galetin

14. The Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers

Joseph Bentz and Harma Ellens

15. Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism

Nnena A. Finn and Melissa L. Kemp

Part IV. Variability in Kinetics

16. Variability in Human in vitro Enzyme Kinetics

Ying-Hong Wang and Christopher R. Gibson

17. Sources of Interindividual Variability

Yvonne Lin and Kenneth E. Thummel

Part V. Case Studies

18. Case Study 1. Practical Considerations with Experimental Design and Interpretation

John T. Barr, Darcy R. Flora, and Otito Iwuchukwu

19. Case Study 2. Practical Analytical Considerations for Conducting in vitro Enzyme Kinetic Studies

Upendra A. Argikar and Swati Nagar

20. Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies - Real Life Examples

Yongmei Li, Michelle McCabe, Lalitha Podila, Timothy S. Tracy, and Donald J. Tweedie

21. Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast

Ken Korzekwa

22. Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A, MRP2 or OATP1B1 in Drug Development

Ian Templeton, Gary Eichenbaum, Rucha Sane, and Jin Zhou

23. Case Study 6. Drug Transporters: in vitro Solutions for Translatable Outcomes

Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Weiskircher, and Ismael J. Hidalgo

24. Case Study 7. Compiled Aha Moments in Enzyme Kine

Автор: Bhaskarwar Madhumati, Joshi Anjulika, Bhaskarwar Ashok N.
Название: Liposomes: Fundamentals, Properties, and Applications for Targeted Drug Delivery
ISBN: 1944749276 ISBN-13(EAN): 9781944749279
Издательство: Mare Nostrum (Eurospan)
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Цена: 6264.00 р.
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Описание: This book throws light on the various methods of preparation and characterization of liposomes.

With the advancements in technology since their discovery, newer methods of generating liposomes have been developed. Needless to say, over time liposomes have been modified to a large extent and engineered to suit many of our growing needs. This book throws light on the various methods of preparation and characterization of liposomes. It also discusses the several biochemical and indirect methods that have made it possible to understand the biological and physicochemical mechanisms of liposomes that decide their fate in vivo.

In spite of certain limitations, liposomes have proved to be more suitable for a number of unconventional applications. This versatility of liposomes outlined in the book brings out the importance of these nanoparticles in the future applications of nanotechnology besides targeted drug delivery. Overall, this book provides the necessary information about the various aspects of liposomes for beginners.

Автор: Swati Nagar; Upendra A. Argikar; Donald J. Tweedie
Название: Enzyme Kinetics in Drug Metabolism
ISBN: 1493960466 ISBN-13(EAN): 9781493960460
Издательство: Springer
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Цена: 21661.00 р.
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Описание:

1. Enzyme Kinetics in Drug Metabolism - Fundamentals and Applications

Swati Nagar, Upendra A. Argikar, and Donald J. Tweedie

Part I. Fundamentals of Enzyme Kinetics

2. Fundaments of Enzyme Kinetics

Eleanore Seibert and Timothy S. Tracy

3. Different Enzyme Kinetic Models

Eleanore Seibert and Timothy S. Tracy

4. Reversible Mechanisms of Enzyme Inhibitors and Resulting Clinical Significance

Barbara Ring, Steven A. Wrighton, and Michael Mohutsky

5. Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions

Michael Mohutsky and Stephen D. Hall

6. Multi-Enzyme Kinetics and Sequential Metabolism

Larry C. Wienkers and Brooke VandenBrink

7. Consideration of the Unbound Drug Concentration in Enzyme Kinetics

Nigel J. Waters, R. Scott Obach, and Li Di

Part II. Kinetics of Drug Metabolizing Enzymes and Transporters

8. Enzyme Kinetics of Oxidative Metabolism - Cytochromes P450

Ken Korzekwa

9. Enzyme Kinetics, Pharmacokinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase

John T. Barr, Kanika Choughule, and Jeffrey P. Jones

10. Enzyme Kinetics of Conjugative Enzymes - PAPS

Margaret O. James

11. Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)

Jin Zhou and John Miners

12. Principles and Experimental Considerations for in vitro Transporter Interaction Assays

Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Wiskercher, and Ismael J. Hidalgo

Part III. Modeling Considerations

13. Rationalising Under-Prediction of Drug Clearance from Enzyme and Transporter Kinetic Data - from in vitro Tools to Mechanistic Modeling

Aleksandra Galetin

14. The Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers

Joseph Bentz and Harma Ellens

15. Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism

Nnena A. Finn and Melissa L. Kemp

Part IV. Variability in Kinetics

16. Variability in Human in vitro Enzyme Kinetics

Ying-Hong Wang and Christopher R. Gibson

17. Sources of Interindividual Variability

Yvonne Lin and Kenneth E. Thummel

Part V. Case Studies

18. Case Study 1. Practical Considerations with Experimental Design and Interpretation

John T. Barr, Darcy R. Flora, and Otito Iwuchukwu

19. Case Study 2. Practical Analytical Considerations for Conducting in vitro Enzyme Kinetic Studies

Upendra A. Argikar and Swati Nagar

20. Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies - Real Life Examples

Yongmei Li, Michelle McCabe, Lalitha Podila, Timothy S. Tracy, and Donald J. Tweedie

21. Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast

Ken Korzekwa

22. Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A, MRP2 or OATP1B1 in Drug Development

Ian Templeton, Gary Eichenbaum, Rucha Sane, and Jin Zhou

23. Case Study 6. Drug Transporters: in vitro Solutions for Translatable Outcomes

Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Weiskircher, and Ismael J. Hidalgo

24. Case Study 7. Compiled Aha Moments in Enzyme Kine

Автор: Cornish-Bowden
Название: Fundamentals of Enzyme Kinetics, 4th Edition
ISBN: 3527330747 ISBN-13(EAN): 9783527330744
Издательство: Wiley
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Цена: 8078.00 р.
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Описание: Now in its fourth edition, this textbook is one of the few titles worldwide to cover enzyme kinetics in its entire scope and the only one to include its implications for bioinformatics and systems biology. Multi-enzyme complexes and cooperativity are therefore treated in more detail than in any other textbook on the market.

Автор: Han, Baoguo
Название: Fiber-Reinforced Nanocomposites: Fundamentals And Applications
ISBN: 0128199040 ISBN-13(EAN): 9780128199046
Издательство: Elsevier Science
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Цена: 28970.00 р.
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Fiber-reinforced Nanocomposites: Fundamentals and Applications explores the fundamental concepts and emerging applications of fiber-reinforced nanocomposites in the automobile, aerospace, transportation, construction, sporting goods, optics, electronics, acoustics and environmental sector. In addition, the book provides a detailed overview of the properties of fiber-reinforced nanocomposites, including discussion on embedding these high-strength fibers in matrices. Due to the mismatch in structure, density, strain and thermal expansion coefficients between matrix and fibers, their thermo-mechanical properties strongly depend not only on the preparative methods, but also on the interaction between reinforcing phase and matrix phase.

Автор: Osswald T., Osswald Tim A., Rudolph Natalie
Название: Polymer Rheology: Fundamentals and Applications
ISBN: 1569905177 ISBN-13(EAN): 9781569905173
Издательство: Mare Nostrum (Eurospan)
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Цена: 12473.00 р.
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Описание: Provides a background in polymer rheology to both engineering students and practicing engineers. The book includes sufficient technical information and practical examples to enable the reader to understand the complex rheological behaviour of polymers, to make the right decisions regarding rheological testing methods, and to troubleshoot rheology related problems encountered in polymer processing.

Автор: Dhoble, S. J.
Название: The Fundamentals and Applications of Light-Emitting Diodes
ISBN: 012819605X ISBN-13(EAN): 9780128196052
Издательство: Elsevier Science
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Цена: 27791.00 р.
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Описание:

Traditional light sources are fast being replaced by light-emitting diodes (LEDs). The fourth generation of lighting is completely dominated by LED luminaires. Apart from lighting, LEDs have extended its hold on other fields such as digital communications, horticulture, medical fields, space research, art and culture, display devices, entertainment, etc. The technological promises offered by LEDs have elevated it as a front-runner in the lighting industry. This book will explore the journey of LEDs for readers belonging to scientific community.