Mechanisms of Cell Death and Approaches to Neuroprotection/Disease Modification in Parkinson`s Disease, 2,
Автор: Cristina Sampaio, Christopher G. Goetz... Название: Rating Scales in Parkinson`s Disease Clinical Practice and Research ISBN: 0199783101 ISBN-13(EAN): 9780199783106 Издательство: Oxford Academ Рейтинг: Цена: 12197.00 р. 17424.00-30% Наличие на складе: Есть (1 шт.) Описание: Parkinson Disease (PD) has been present. However the understanding of all intricacies of rating scales development was not widely available and the first attempts were relatively crude. In 2002, the Movement Disorders Society created a task force to systemize the measurement of Parkinson's Disease. Since then, the Task Force has produced and published several critiques to the available rating scales addressing both motor and non-motor domains of Parkinson Disease. Additionally the task force initiated a project to develop a new version of the UPDRS, the MDS-UPDRS. But none of this was made available in one convenient source. Until now. Rating Scales in Parkinson's Disease: Clinical Practice and Research is written for researchers from the medical and social sciences, and for health professionals wishing to evaluate the progress of their patients suffering from Parkinson's Disease. The book is both exhaustive in the description of the scales and informative on the advantages and limitations of each scale. As such, the text clearly guides readers on how to choose and use the instruments available. Extensive cross-referenced tables and charts closely integrate the parts of the book to facilitate readers in moving from one symptom domain to another. Features Based on a consistent and uniform methodology A clear consolidation of material otherwise only available in journals The first comprehensive book of its kind
Автор: Paul Lapchak; John H. Zhang Название: Neuroprotective Therapy for Stroke and Ischemic Disease ISBN: 3319453440 ISBN-13(EAN): 9783319453446 Издательство: Springer Рейтинг: Цена: 34937.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A critical and comprehensive look at current state-of-the-art scientific and translational research being conducted internationally, in academia and industry, to address new ways to provide effective treatment to victims of ischemic and hemorrhagic stroke and other ischemic diseases.
Описание: This volume brings together various theories of how aberrations in mitochondrial function and morphology contribute to neurodegeneration in idiopathic and familial forms of Parkinson’s disease. Moreover, it comprehensively reviews the current search for therapies, and proposes how molecules are involved in specific functions as attractive therapeutic targets. It is expected to facilitate critical thought and discussion about the fundamental aspects of neurodegeneration in Parkinson’s disease and foster the development of therapeutic strategies among researchers and graduate students. Theories of idiopathic Parkinson’s etiology support roles for chronic inflammation and exposure to heavy metals or pesticides. Interestingly, as this project proposes, a case can be made that abnormalities in mitochondrial morphology and function are at the core of each of these theories. In fact, the most common approach to the generation of animal and cell-culture models of idiopathic Parkinson’s disease involves exposure to mitochondrial toxins. Even more compelling is the fact that most familial patients harbor genetic mutations that cause disruptions in normal mitochondrial morphology and function. While there remains to be no effective treatment for Parkinson’s disease, efforts to postpone, prevent and “cure” onset mitochondrial aberrations and neurodegeneration associated with Parkinson’s disease in various models are encouraging. While only about ten percent of Parkinson’s patients inherit disease-causing mutations, discovering common mechanisms by which familial forms of Parkinson’s disease manifest will likely shed light on the pathophysiology of the more common idiopathic form and provide insight to the general process of neurodegeneration, thus revealing therapeutic targets that will become more and more accessible as technology improves.
Описание: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Автор: Verstreken, Patrik Название: Parkinson`s Disease ISBN: 0128037830 ISBN-13(EAN): 9780128037836 Издательство: Elsevier Science Рейтинг: Цена: 11193.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Parkinson’s Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson’s disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology. . This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes.Readers will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson’s.
Описание: This volume brings together various theories of how aberrations in mitochondrial function and morphology contribute to neurodegeneration in idiopathic and familial forms of Parkinson’s disease. Moreover, it comprehensively reviews the current search for therapies, and proposes how molecules are involved in specific functions as attractive therapeutic targets. It is expected to facilitate critical thought and discussion about the fundamental aspects of neurodegeneration in Parkinson’s disease and foster the development of therapeutic strategies among researchers and graduate students. Theories of idiopathic Parkinson’s etiology support roles for chronic inflammation and exposure to heavy metals or pesticides. Interestingly, as this project proposes, a case can be made that abnormalities in mitochondrial morphology and function are at the core of each of these theories. In fact, the most common approach to the generation of animal and cell-culture models of idiopathic Parkinson’s disease involves exposure to mitochondrial toxins. Even more compelling is the fact that most familial patients harbor genetic mutations that cause disruptions in normal mitochondrial morphology and function. While there remains to be no effective treatment for Parkinson’s disease, efforts to postpone, prevent and “cure” onset mitochondrial aberrations and neurodegeneration associated with Parkinson’s disease in various models are encouraging. While only about ten percent of Parkinson’s patients inherit disease-causing mutations, discovering common mechanisms by which familial forms of Parkinson’s disease manifest will likely shed light on the pathophysiology of the more common idiopathic form and provide insight to the general process of neurodegeneration, thus revealing therapeutic targets that will become more and more accessible as technology improves.
Автор: Das, Undurti N. Название: Clinical Trials In Parkinson`s Disease ISBN: 1071609149 ISBN-13(EAN): 9781071609149 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume looks at major clinical trials for motor and non-motor symptoms in Parkinson`s Disease (PD) and covers important aspects, including trial design, sample selection, and outcome selection.
Автор: Segura-aguilar, Juan (university Of Chile, Santiago, Chile) Название: Clinical studies and therapies in parkinson`s disease ISBN: 0128221208 ISBN-13(EAN): 9780128221204 Издательство: Elsevier Science Рейтинг: Цена: 19875.00 р. Наличие на складе: Поставка под заказ.
Описание: Second novel in the chilling and epic new fantasy series from the bestselling and critically-acclaimed author of PRINCE OF THORNS and RED SISTER. `If you like dark you will love Mark Lawrence. And when the light breaks through and it all makes sense, the contrast is gorgeous` ROBIN HOBB
Автор: Menza Название: Psychiatric Care In Parkinsons Disease ISBN: 1841844918 ISBN-13(EAN): 9781841844916 Издательство: Taylor&Francis Рейтинг: Цена: 6430.00 р. Наличие на складе: Поставка под заказ.
Описание: A practical guide to the management of various clinical issues seen in patients with Parkinson's Disease (PD), this text emphasizes the need for coordinated care between the various professionals, as well as between professionals and caregivers. Providing an update on current developments in the neurology and management of PD, as well as the understanding and treatment of non-motor aspects of PD, the book also includes a variety of topics such as depression, psychosis, and anxiety
Автор: Jankovic Название: Parkinson`s Disease and Movement Disorders ISBN: 0781735157 ISBN-13(EAN): 9780781735155 Издательство: Lippincott Williams & Wilkins Рейтинг: Цена: 12012.00 р. Наличие на складе: Поставка под заказ.
Описание: This multi-authored textbook provides detailed information on both the basic science and clinical factors affecting the diagnosis and management of Parkinson's and other movement disorders. The Fourth Edition continues to provide the internationally renowned array of expert contributors and reliable, clinically essential perspectives. FEATURES: Addresses both common and rare movent disorders Includes both basic science and clinical information - including discussions of pathophysiology, diagnosis, and medical and surgical treatment Exclusive content on behavioral and psychological issues NEW TO THE FOURTH EDITION: New information on genetics, cell death, neuroimaging, surgical treatments, and ancillary drugs that prolong the effectiveness of traditional drug therapies. New chapters address the mechanisms and prevention of cell death (neuroprotection); psychiatric disorders in Parkinson's Disease; and Botulin Toxin as a treatment for spasticity. New, more convenient siz
Автор: Stamelou, Maria Название: Parkinsonism Beyond Parkinson`S Disease,149 ISBN: 0128177306 ISBN-13(EAN): 9780128177303 Издательство: Elsevier Science Рейтинг: Цена: 27791.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Parkinsonism beyond Parkinson's Disease, Volume 149, the latest release in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including How to approach a patient with parkinsonism - red flags for atypical parkinsonism, The 'classic' atypical parkinsonian disorders, Classification of atypical parkinsonism per pathology vs. phenotypes, Progressive supranuclear palsy, Corticobasal degeneration, Multiple system atrophy, Atypical parkinsonism in other sporadic and genetic neurodegenerative diseases, Sporadic 'Atypical' Parkinson's disease, and much more.
Автор: Shelton Helena Название: Parkinson`s Disease: A Growing Concern ISBN: 1632427168 ISBN-13(EAN): 9781632427168 Издательство: Неизвестно Рейтинг: Цена: 23335.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
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