The Carbonic Anhydrases: Current and Emerging Therapeutic Targets, Chegwidden W. Richard, Carter Nicholas D.
Автор: W.R. Chegwidden; N.D. Carter; Y.H. Edwards Название: The Carbonic Anhydrases ISBN: 3034895704 ISBN-13(EAN): 9783034895705 Издательство: Springer Рейтинг: Цена: 41925.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer.
Автор: N.D. Carter; S.J. Dodgson; G. Gros; R.E. Tashian Название: The Carbonic Anhydrases ISBN: 1489907521 ISBN-13(EAN): 9781489907523 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: As we approach the twenty-first century the problems of industrialization are evident: we find there is a greenhouse effect, the ozone layer is being depleted, the rain is acidified, and there is a terrible problem of increasing C0 concentrations in the atmo- 2 sphere.
Описание: These are structurally related to the beta CAs, but have a mechanism more similar to the alpha CAs.
Автор: N.D. Carter; S.J. Dodgson; G. Gros; R.E. Tashian Название: The Carbonic Anhydrases ISBN: 0306436361 ISBN-13(EAN): 9780306436369 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: As we approach the twenty-first century the problems of industrialization are evident: we find there is a greenhouse effect, the ozone layer is being depleted, the rain is acidified, and there is a terrible problem of increasing C0 concentrations in the atmo- 2 sphere.
Автор: Supuran, Claudiu T. Название: Carbonic Anhydrases ISBN: 012816476X ISBN-13(EAN): 9780128164761 Издательство: Elsevier Science Рейтинг: Цена: 32844.00 р. Наличие на складе: Поставка под заказ.
Описание: Besides the ITIL(R) 4 Foundation Courseware - English (ISBN: 9789401803939) publication you are advised to obtain the publication ITIL(R) 4 - A Pocket Guide (ISBN: 978 94 018 0439 4).The course is designed as an introduction to ITIL 4 and enables you to understand a new way to look at IT Service Management through a Service Value System (SVS). ITIL 4 provides an end-to-end picture of what means to contribute to business value, and also integrates concepts from models such as Lean IT, Agile and DevOps.This course is for those who are involved in the delivery of IT services and need an understanding of best practice in IT Service Management. Student must pass a 60 minute, 40 question closed book multiple choice, examination with a passing score of 65% in order to receive this certification. You can write the exam at any time and at any place after the course. The test is done via your own computer proctored via webcam.Candidates wishing to be trained and pass the exam for this qualification would be recommended to have a general awareness of IT and appreciation of their own business environment.You`ll learn:¢ Understand the key concepts of service management¢ Understand how the ITIL guiding principles can help an organization adopt and adapt service management¢ Understand the four dimensions of service management¢ Understand the purpose and components of the ITIL service value system¢ Understand the activities of the service value chain, and how they interconnect¢ Know the purpose and key terms of 18 ITIL practices¢ Understand 7 ITIL practices
Описание: The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms. The CAs are metalloenzymes which are comprised of 5 structurally different families: the alpha, beta, gamma, and delta, and epsilon classes. The alpha class is found primarily in animals with several isoforms associated with human disease. The beta CAs are expressed primarily in plants and are the most divergent. The gamma CAs are the most ancient. These are structurally related to the beta CAs, but have a mechanism more similar to the alpha CAs. The delta CAs are found in marine algae and diflagellates. The epsilon class is found in prokaryotes in which it is part of the carboxysome shell perhaps supplying RuBisCO with CO2 for carbon fixation. With the excitement surrounding the discovery of disease-related CAs, scientists have redoubled their efforts to better understand structure-function relationships, to design high affinity, isotype-specific inhibitors, and to delineate signaling systems that play regulatory roles over expression and activity. We have designed the book to cover basic information of mechanism, structure, and function of the CA families. The authors included in this book bring to light the newest data with regard to the role of CA in physiology and pathology, across phylums, and in unique environmental niches.
Автор: Matulis Название: Carbonic Anhydrase as Drug Target ISBN: 3030127788 ISBN-13(EAN): 9783030127787 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Поставка под заказ.
Описание: This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design.
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