Mesenchymal Stem Cell in Veterinary Sciences, Gugjoo Mudasir Bashir, Pal Amar
Автор: Mohan C Vemuri; Lucas G. Chase; Mahendra S. Rao Название: Mesenchymal Stem Cell Assays and Applications ISBN: 1493957791 ISBN-13(EAN): 9781493957798 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book shows how to propagate, characterize, and engineer this special cell type. Using the Methods in Molecular Biology (TM) format, each chapter offers an introduction, step-by-step methods, materials list, and tips on troubleshooting and avoiding pitfalls.
Описание: Written by researchers from around the globe, this book reviews the properties of Mesenchymal stem cells, summarizes the current state of knowledge in stem cell research, reports on cutting-edge methods and protocols and offers insight on effective therapies.
Автор: Lucas G. Chase; Mohan C Vemuri Название: Mesenchymal Stem Cell Therapy ISBN: 1627039147 ISBN-13(EAN): 9781627039147 Издательство: Springer Рейтинг: Цена: 21661.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.
Автор: Darwin J. Prockop; Donald G. Phinney; Bruce A. Bun Название: Mesenchymal Stem Cells ISBN: 1617377678 ISBN-13(EAN): 9781617377679 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: For over forty years, mesenchymal stem cells (MSCs) have been scrutinized and studied, garnering much attention due to their broad therapeutic efficacy. In this essential book, leaders in the field were assembled to contribute detailed methodologies for the isolation and characterization of human and rodent MSCs.
Автор: Charles J. Malemud; Eben Alsberg Название: Mesenchymal Stem Cells and Immunomodulation ISBN: 331946731X ISBN-13(EAN): 9783319467313 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This essential volume explores mesenchymal stem cells (MSCs) and their potential to suppress immune-mediated inflammation. The chapters examine applications in autoimmune diseases such as lupus, rheumatoid arthritis and multiple sclerosis; blood cancers such as leukemia and lymphoma; and reproductive complications, specifically pre-term labor and use of MSCs in vitro and in animal models to discover methods of suppressing the causal inflammatory response. It also further defines the methodologies required to develop research on MSCs in vitro into established preclinical animal models including those which are proven replicas of autoimmunity and pre-term labor, to name but two.
Mesenchymal Stem Cells and Immunomodulation, part of Springer’s Stem Cell Biology and Regenerative Medicine, is an invaluable resource for researchers and clinicians working with stem cells, autoimmune disease, oncology, and reproductive medicine.
Автор: Gugjoo Mudasir Bashir, Pal Amar Название: Mesenchymal Stem Cell in Veterinary Sciences ISBN: 9811560366 ISBN-13(EAN): 9789811560361 Издательство: Springer Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book focuses on mesenchymal stem cells (MSCs) of animal origin, including their isolation, characterization, and clinical applications. After briefly discussing the historical development of the field of stem cell research, it describes the basic properties and nature of stem cells particularly in relation to MSCs.
Описание: Written by researchers from around the globe, this book reviews the properties of Mesenchymal stem cells, summarizes the current state of knowledge in stem cell research, reports on cutting-edge methods and protocols and offers insight on effective therapies.
Автор: Malemud Charles J., Alsberg Eben Название: Mesenchymal Stem Cells and Immunomodulation ISBN: 3319835734 ISBN-13(EAN): 9783319835730 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Overview.- Part I: Autoimmune Diseases.- Chapter 1: Altering Immune-Mediated Inflammatory Responses With Stem Cells.- Chapter 2: Rheumatoid Arthritis.- Chapter 3: Systemic Lupus Erythematosus.- Chapter 4: Crohn's Diseases.- Chapter 5: Multiple Sclerosis.- Part II: Cancer.- Chapter 6: Eliminating Cancer with Stem Cells by Correcting Dysfunctional Immunity.- Chapter 7: Asymmetric Cell Division of Stem and Progenitor Cells in Homeostasis and Cancer.- Chapter 8: Stem Cells: Modifiers of Defective Transcription Factor Activity Induced by Cytokines in Cancer.- Chapter 9: Therapeutic Targeting of Prostate Cancer with Stem Cells.- Chapter 10: The Efficacy of Stem Cells in Experimental Animal Models of Leukemia.- Part III: Cardiovascular Disease.- Chapter 11: Immune-Mediated Inflammation in Heart Disease.- Chapter 12: Stem Cell Therapy: Dampening Immune-Mediated Inflammation in Coronary Artery Disease.- Part IV: Neurodegenerative Diseases.- Chapter 13: Similarities and Differences in Stem Cells Between Cancer, Normal and Injured Brain.- Chapter 2: Defective Immune Modulation in Parkinson's Disease: Potential Role of Stem Cells.- Part V: Immune Modulation In Pregnancy and Parturition.- Chapter 14: Role of Immune-Mediated Inflammation in Pregnancy.- Chapter 15: Cytokine-Mediated Inflammation in Pre-Term Labor.- Chapter 16: Using Stem Cells to Prevent Inflammation-Induced Pre-Term Labor.
Автор: Birgit Weyand; Massimo Dominici; Ralf Hass; Roland Название: Mesenchymal Stem Cells - Basics and Clinical Application I ISBN: 3642429874 ISBN-13(EAN): 9783642429873 Издательство: Springer Рейтинг: Цена: 30039.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Prospective Isolation and Characterization of Human Bone Marrow-Derived MSCs, by A. Harichandan, K. Sivasubramaniyan, H.-J. Buhring Urine as a Source of Stem Cells, by Christina Benda, Ting Zhou, Xianming Wang, Weihua Tian, Johannes Grillari, Hung-Fat Tse, Regina Grillari-Voglauer, Duanqing Pei, Miguel A. Esteban Expansion of Mesenchymal Stem/Stromal Cells under Xenogenic-Free Culture Conditions, by Sven Kinzebach, Karen Bieback Adipose-Derived Mesenchymal Stem Cells: Biology and Potential Applications, by Danielle Minteer, Kacey G Marra, J Peter Rubin Potential for Osteogenic and Chondrogenic Differentiation of MSC, by Antonina Lavrentieva, Tim Hatlapatka, Anne Neumann, Birgit Weyand, Cornelia Kasper Potential for Neural Differentiation of Mesenchymal Stem Cells, by Letizia Ferroni, Chiara Gardin, Ilaria Tocco, Roberta Epis, Alessandro Casadei, Vincenzo Vindigni, Giuseppe Mucci, Barbara Zavan Migratory Properties of Mesenchymal Stem Cells, by Thomas Dittmar, Frank Entschladen Dissecting Paracrine Effectors for Mesenchymal Stem Cells, by Stefania Bruno, Federica Collino, Ciro Tetta, Giovanni Camussi Proteomics Approaches in the Identification of Molecular Signatures of Mesenchymal Stem Cells, by Yin Xiao, Jiezhong Chen Does the Adult Stroma Contain Stem Cells?, by Richard Schafer
Автор: Peiman Hematti; Armand Keating Название: Mesenchymal Stromal Cells ISBN: 1493941291 ISBN-13(EAN): 9781493941292 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this book, leading authorities actively involved in this field provide state-of-the-art knowledge of the basic biology, translational requirements and latest clinical experience with Mesenchymal Stromal Cell (MSC) biology.
Автор: Gerhard Gross Название: Stem Cell-dependent Therapies ISBN: 3110298260 ISBN-13(EAN): 9783110298260 Издательство: Walter de Gruyter Цена: 31603.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Multipotent mesenchymal stem cells (MSCs) are a heterogeneous population of cells which reside in a variety of tissues. They differentiate into several mesodermal lineages, secrete a multitude of trophic factors and contribute to tissue homeostasis. MSCs are able to exert immunosuppressive activities by interfering with inflammatory cytokine production and with T- and B-cell proliferation. These immunomodulating properties make MSCs promising candidates for the treatment of chronic inflammatory and autoimmune disorders. There are, however, certain caveats involved including inappropriate migration of cells in the body, immune rejection, tumor formation, or graft versus host disease (GvHD). This book investigates the current state of the MSC-dependent therapy of chronic inflammatory disorders and autoimmune diseases. Among the covered topics are GvHD, chronic kidney, liver and lung disease, ischemic heart and inflammatory bowel disease, diabetes, osteoarthritis, various rheumatic and neurological disorders and, lastly, tumors and solid organ transplantations. This book also questions the immunoprivileged status of MSCs, discusses the therapeutic role of MSCs in experimental animal disease models and their translation to the corresponding human disorders, envisions a role for MSCs in tumor interventions and, lastly, describes a systems biology approach for stem cells and inflammation.
Автор: Choudhary Ratan Kumar, Choudhary Shanti Название: Stem Cells in Veterinary Science ISBN: 9811634637 ISBN-13(EAN): 9789811634635 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book explores the potential applications of animal stem cells in veterinary medicine. In turn, the book discusses the challenges of using stem cells in regenerative medicine and emphasizes the importance of understanding the action of stem cells and preclinical evidence for ensuring safety and therapeutic efficacy.
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