Автор: Cristina Sampaio, Christopher G. Goetz... Название: Rating Scales in Parkinson`s Disease Clinical Practice and Research ISBN: 0199783101 ISBN-13(EAN): 9780199783106 Издательство: Oxford Academ Рейтинг: Цена: 12197.00 р. 17424.00-30% Наличие на складе: Есть (1 шт.) Описание: Parkinson Disease (PD) has been present. However the understanding of all intricacies of rating scales development was not widely available and the first attempts were relatively crude. In 2002, the Movement Disorders Society created a task force to systemize the measurement of Parkinson's Disease. Since then, the Task Force has produced and published several critiques to the available rating scales addressing both motor and non-motor domains of Parkinson Disease. Additionally the task force initiated a project to develop a new version of the UPDRS, the MDS-UPDRS. But none of this was made available in one convenient source. Until now. Rating Scales in Parkinson's Disease: Clinical Practice and Research is written for researchers from the medical and social sciences, and for health professionals wishing to evaluate the progress of their patients suffering from Parkinson's Disease. The book is both exhaustive in the description of the scales and informative on the advantages and limitations of each scale. As such, the text clearly guides readers on how to choose and use the instruments available. Extensive cross-referenced tables and charts closely integrate the parts of the book to facilitate readers in moving from one symptom domain to another. Features Based on a consistent and uniform methodology A clear consolidation of material otherwise only available in journals The first comprehensive book of its kind
Автор: Glenda Halliday, PhD... Название: Non-dopamine Lesions in Parkinson`s Disease ISBN: 0195371089 ISBN-13(EAN): 9780195371086 Издательство: Oxford Academ Рейтинг: Цена: 21780.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Parkinson's disease becomes apparent only after substantial loss (>60%) of the dopamine neurons in the substantia nigra. By this time there has already been widespread neural inclusion formation in the peripheral and central nervous system of patients with the disease, although this has only been recognized more recently. Degeneration in these widespread regions of the peripheral and central nervous system is now known to impact on disease symptoms, progression and treatment over time. This book aims to provide a comprehensive review of these non-dopamine lesions in Parkinson's disease by assessing our current knowledge of their presence and pathophysiology, how they relate to different symptoms and, where relevant, discuss how they may be potentially treated. The book addresses most of the known symptoms that occur in patients with Parkinson's disease. In addition to the classic motor triad, motor speech, eye movements, olfactory dysfunction, autonomic dysfunction, pain and sensory abnormalities, sleep disturbances, depression and apathy, dopamine dysregulation syndromes, hallucinations and psychoses, cognitive impairment and dementia, and systemic manifestations are all reviewed. Early selective cell loss in non-dopaminergic regions is highlighted (the glutamate projection neurons of the presupplementary motor cortex and caudal intralaminar thalamus) in addition to the widespread inclusion formation in many regions outside the basal ganglia that characterize the disease. Overall this book provides a comprehensive analysis of the lesions associated with the most common symptoms found in patients with Parkinson's disease.
Adenosine A2A receptors: localization and function.- Allosteric Mechanisms in the adenosine A2A-dopamine D2 receptor heteromer.- Adenosine A2A receptor antagonists in drug development.- Adenosine A2A Receptors and Neurotrophic Factors: Relevance for Parkinson's Disease.- Role of adenosine A2A receptors in the control of neuroinflammation - relevance for Parkinson's disease.- Purines in Parkinson's: Adenosine A2A receptors and urate as targets for neuroprotection.- Adenosine A2A receptor antagonists as drugs for symptomatic control of Parkinson's disease in preclinical studies.- Dopamine/adenosine interactions related to tremor in animal models of Parkinsonism.- Adenosine A2A receptor antagonists in L-DOPA-induced motor fluctuations.- Adenosine A2A receptor-mediated control of non-motor functions in Parkinson's disease.- Imaging Studies with A2A Receptor Antagonists.- Caffeine and neuroprotection in Parkinson's disease.- The story of istradefylline - the first approved A2A antagonist for the treatment of Parkinson's disease.- Adenosinergic Receptor Antagonists: Clinical Experience in Parkinson's Disease.- Adenosinergic regulation of sleep-wake behavior in the basal ganglia.
Автор: Cram David L., Schechter Steven H. Название: Understanding Parkinson`s Disease: A Self-Help Guide ISBN: 1943886458 ISBN-13(EAN): 9781943886456 Издательство: Неизвестно Цена: 2752.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: If you've been told by your doctor, "You have Parkinson's disease," you probably found it difficult to hear those words. Such a diagnosis can be frightening and leave you filled with questions. How will it affect your life? What are your treatment options? These authors are uniquely qualified to understand your concerns. Steven Schechter, M.D., is a neurologist who has treated thousands of patients with Parkinson's disease, and David Cram, M.D., lived with the disease himself. Among the topics they cover are: diagnosis, symptoms and stages, the emotional side of PD--conquering fear and denial, choosing the right health care team, drug therapy--medications and how they work, surgical options, deep brain stimulation, the importance of exercise, coping with day-to-day problems, and care for caregivers.
Описание: The current book represents an elaborated study of the etiology and pathophysiology of Parkinson's disease, which is a complex neurological disorder. In this book, the ecological and biological agents which become the cause of Parkinson's disease have bee
Автор: Rajesh Pahwa Название: Handbook of Parkinson`s Disease ISBN: 1841849081 ISBN-13(EAN): 9781841849089 Издательство: Taylor&Francis Рейтинг: Цена: 33686.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book describes the phenomenological features, assessment, and treatment of the wide variety of neurobehavioral conditions accompanying Parkinson`s disease and other movement disorders. Chapters from leading researchers in the field discuss general assessment strategies, quality of life, and neurophysiology and neuropathology relevant to neuropsychological features of movement disorders.
Автор: Martin, Colin R. Название: Diagnosis And Management In Parkinson`S Disease ISBN: 0128159464 ISBN-13(EAN): 9780128159460 Издательство: Elsevier Science Рейтинг: Цена: 26444.00 р. Наличие на складе: Поставка под заказ.
Описание: Collins Big Cat Phonics for Letters and Sounds features exciting fiction and non-fiction decodable readers to enthuse and inspire children. They are fully aligned to Letters and Sounds Phases 1-6 and contain notes in the back. The Handbooks provide support in demonstration and modelling, monitoring comprehension and expanding vocabulary.
Автор: Aleksandar Videnovic; Birgit H?gl Название: Disorders of Sleep and Circadian Rhythms in Parkinson`s Disease ISBN: 3709116309 ISBN-13(EAN): 9783709116302 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book details sleep and circadian disorders associated with Parkinson`s Disease as well as epidemiology, etiology, pathogenesis, differential diagnosis, and treatment. It also examines the potential impact of surgical therapies on sleep-wake cycles.
Описание: Collins Big Cat Phonics for Letters and Sounds features exciting fiction and non-fiction decodable readers to enthuse and inspire children. They are fully aligned to Letters and Sounds Phases 1-6 and contain notes in the back. The Handbooks provide support in demonstration and modelling, monitoring comprehension and expanding vocabulary.
Автор: Walsh Aubrey Название: Parkinson`s Disease: Symptoms, Pathophysiology and Treatment ISBN: 1632427206 ISBN-13(EAN): 9781632427205 Издательство: Неизвестно Рейтинг: Цена: 23335.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
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