Adenosine A2A receptors: localization and function.- Allosteric Mechanisms in the adenosine A2A-dopamine D2 receptor heteromer.- Adenosine A2A receptor antagonists in drug development.- Adenosine A2A Receptors and Neurotrophic Factors: Relevance for Parkinson's Disease.- Role of adenosine A2A receptors in the control of neuroinflammation - relevance for Parkinson's disease.- Purines in Parkinson's: Adenosine A2A receptors and urate as targets for neuroprotection.- Adenosine A2A receptor antagonists as drugs for symptomatic control of Parkinson's disease in preclinical studies.- Dopamine/adenosine interactions related to tremor in animal models of Parkinsonism.- Adenosine A2A receptor antagonists in L-DOPA-induced motor fluctuations.- Adenosine A2A receptor-mediated control of non-motor functions in Parkinson's disease.- Imaging Studies with A2A Receptor Antagonists.- Caffeine and neuroprotection in Parkinson's disease.- The story of istradefylline - the first approved A2A antagonist for the treatment of Parkinson's disease.- Adenosinergic Receptor Antagonists: Clinical Experience in Parkinson's Disease.- Adenosinergic regulation of sleep-wake behavior in the basal ganglia.
Автор: Stamelou, Maria Название: Parkinsonism Beyond Parkinson`S Disease,149 ISBN: 0128177306 ISBN-13(EAN): 9780128177303 Издательство: Elsevier Science Рейтинг: Цена: 27791.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Parkinsonism beyond Parkinson's Disease, Volume 149, the latest release in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including How to approach a patient with parkinsonism - red flags for atypical parkinsonism, The 'classic' atypical parkinsonian disorders, Classification of atypical parkinsonism per pathology vs. phenotypes, Progressive supranuclear palsy, Corticobasal degeneration, Multiple system atrophy, Atypical parkinsonism in other sporadic and genetic neurodegenerative diseases, Sporadic 'Atypical' Parkinson's disease, and much more.
Описание: This volume brings together various theories of how aberrations in mitochondrial function and morphology contribute to neurodegeneration in idiopathic and familial forms of Parkinson’s disease. Moreover, it comprehensively reviews the current search for therapies, and proposes how molecules are involved in specific functions as attractive therapeutic targets. It is expected to facilitate critical thought and discussion about the fundamental aspects of neurodegeneration in Parkinson’s disease and foster the development of therapeutic strategies among researchers and graduate students. Theories of idiopathic Parkinson’s etiology support roles for chronic inflammation and exposure to heavy metals or pesticides. Interestingly, as this project proposes, a case can be made that abnormalities in mitochondrial morphology and function are at the core of each of these theories. In fact, the most common approach to the generation of animal and cell-culture models of idiopathic Parkinson’s disease involves exposure to mitochondrial toxins. Even more compelling is the fact that most familial patients harbor genetic mutations that cause disruptions in normal mitochondrial morphology and function. While there remains to be no effective treatment for Parkinson’s disease, efforts to postpone, prevent and “cure” onset mitochondrial aberrations and neurodegeneration associated with Parkinson’s disease in various models are encouraging. While only about ten percent of Parkinson’s patients inherit disease-causing mutations, discovering common mechanisms by which familial forms of Parkinson’s disease manifest will likely shed light on the pathophysiology of the more common idiopathic form and provide insight to the general process of neurodegeneration, thus revealing therapeutic targets that will become more and more accessible as technology improves.
Автор: Susan H. Fox; Jonathan M. Brotchie Название: Levodopa-Induced Dyskinesia in Parkinson`s Disease ISBN: 1447165020 ISBN-13(EAN): 9781447165026 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book aims to provide a single reference source on levodopa-induced dyskinesias (LID) from `bench to bedside`. Initial chapters review the clinical features and phenomenology of LID with video examples; epidemiology and genetic risk factors for LID are covered as a background to understanding risk factors for developing LID.
Автор: Lucyna Antkiewicz-Michaluk; Hans Rommelspacher Название: Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants ISBN: 1489987541 ISBN-13(EAN): 9781489987549 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book reports, for the first time, results from behavioral, neurochemical and molecular experiments which demonstrate a range of TIQs and BCs effects - from their rather mild neurotoxic actions to the important neuroprotective and antiaddictive properties.
Автор: Politis, Marios Название: Neuroimaging In Parkinson`S Disease And Related Disorders ISBN: 0128216514 ISBN-13(EAN): 9780128216514 Издательство: Elsevier Science Рейтинг: Цена: 26107.00 р. Наличие на складе: Поставка под заказ.
Описание: My experience as a State Correction Officer inside New Yorks Prisons. As you read Paul Harringtons day-to-day and month-to-month experiences within the states prison system, you will see a broken system one that is full of loopholes, lies, cover-ups and corruption. This system is full of daily violence and numerous officers are injured by violent inmates. Each officer has their unique view of the prison system. Here, Harrington wishes to share his perspective of how different administrations created changes in the daily operations at Fishkill Correctional Facility, where he was stationed after a 15-month stint at Sing Sing. Not every day was
Автор: House, Patrick Название: Experimental Models of Parkinson`s Disease ISBN: 1071614975 ISBN-13(EAN): 9781071614976 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This detailed volume presents a variety of animal models that are commonly used to study sepsis and some key procedures to measure specific disease outcomes.
Описание: Motor dysfunction and cognitive impairment are major symptoms in both Huntington’s Disease (HD) and Parkinson’s Disease (PD). A breakthrough in HD research was the identification of the gene that causes this devastating monogenetic illness. Similarly, several genes were found to cause familial forms of PD. With their identification, a plethora of genetic animal models has been generated and has revolutionized the understanding of the pathobiology and pathophysiology of these disorders. The models allow us to study the earliest manifestations of the diseases behaviorally and neuropathologically and help us understand how they progress over time. Additionally, neurotoxic animal models are still of high interest to the PD field, as they are being used to study e.g. mitochondrial dysfunction in PD. This book focuses on animal models of both diseases and how they have helped and will continue to help understand the behavioral neurobiology in these disorders.
Автор: Martin, Colin R. Название: Diagnosis And Management In Parkinson`S Disease ISBN: 0128159464 ISBN-13(EAN): 9780128159460 Издательство: Elsevier Science Рейтинг: Цена: 26444.00 р. Наличие на складе: Поставка под заказ.
Описание: Collins Big Cat Phonics for Letters and Sounds features exciting fiction and non-fiction decodable readers to enthuse and inspire children. They are fully aligned to Letters and Sounds Phases 1-6 and contain notes in the back. The Handbooks provide support in demonstration and modelling, monitoring comprehension and expanding vocabulary.
Автор: Segura-aguilar, Juan (university Of Chile, Santiago, Chile) Название: Clinical studies and therapies in parkinson`s disease ISBN: 0128221208 ISBN-13(EAN): 9780128221204 Издательство: Elsevier Science Рейтинг: Цена: 19875.00 р. Наличие на складе: Поставка под заказ.
Описание: Second novel in the chilling and epic new fantasy series from the bestselling and critically-acclaimed author of PRINCE OF THORNS and RED SISTER. `If you like dark you will love Mark Lawrence. And when the light breaks through and it all makes sense, the contrast is gorgeous` ROBIN HOBB
Описание: Collins Big Cat Phonics for Letters and Sounds features exciting fiction and non-fiction decodable readers to enthuse and inspire children. They are fully aligned to Letters and Sounds Phases 1-6 and contain notes in the back. The Handbooks provide support in demonstration and modelling, monitoring comprehension and expanding vocabulary.
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