Описание: This book discusses oxidative stress and hormesis from the perspective of an evolutionary ecologist or physiologist. The author illustrates how oxidative stress and hormesis have shaped diversity in organism life-histories, behavioral profiles, morphological phenotypes, and aging mechanisms.
Описание: This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy.
Автор: Orrenius Название: Mitochondrial Signaling in Health and Disease ISBN: 1439880026 ISBN-13(EAN): 9781439880029 Издательство: Taylor&Francis Рейтинг: Цена: 29093.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.
With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include:
Electron transport and energy production
Mitochondrial biogenesis and dynamics
Mitochondrial signaling
Apoptosis and autophagy
Pharmacology signaling
Epigenetic signaling: mitochondrial methylation and acetylation reactions
An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.
Автор: Vittorio Cristini, Eugene Koay, Zhihui Wang Название: An Introduction to Physical Oncology ISBN: 1032242795 ISBN-13(EAN): 9781032242798 Издательство: Taylor&Francis Рейтинг: Цена: 7501.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book introduces the emerging field of physical oncology, and includes recent breakthroughs in how novel mathematical models of physical transport processes incorporate patient tissue and imaging data routinely produced in the clinic to predict the efficacy of many cancer treatment approaches, including chemotherapy and radiation therapy.
Автор: Robert R. Snyder; James J. Kocsis; I. Glenn Sipes; Название: Biological Reactive Intermediates V ISBN: 1475794827 ISBN-13(EAN): 9781475794823 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the Fifth International Symposium held in Munich, Germany, January 4-8, 1995.
Описание: This book discusses oxidative stress and hormesis from the perspective of an evolutionary ecologist or physiologist. The author illustrates how oxidative stress and hormesis have shaped diversity in organism life-histories, behavioral profiles, morphological phenotypes, and aging mechanisms.
Автор: Chakraborti Название: Handbook of Oxidative Stress in Cancer: Therapeutic Aspects ISBN: 9811654212 ISBN-13(EAN): 9789811654213 Издательство: Springer Рейтинг: Цена: 69876.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.
Автор: Stephen M. Roberts; James P. Kehrer; Lars-Oliver K Название: Studies on Experimental Toxicology and Pharmacology ISBN: 331934708X ISBN-13(EAN): 9783319347080 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book focuses on data describing the roles of free radicals and related reactive species, and antioxidants, in the causes and treatments of diseases, examining both clinical and pre-clinical trials, as well as basic research.
Автор: Rahman Название: Hormone Related Cancer Mechanistic and Nanomedicines ISBN: 9811955573 ISBN-13(EAN): 9789811955570 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The nanotheranostics sector provides a very promising strategy for monitoring drug biodistribution and pathology longitudinal processes by integrating the imaging and drug delivery functions in one single nanoformulation, providing vital insights into the identification of tumour and predicting the efficacy of nanomedicine. For its unique properties, which include their small size and biocompatibility and ability to permeate the cellular membrane with carrying drugs, nanomaterials have been used for various biomedical applications. This book covers the progress made in hormone-related cancer and their management by nonmedicinal therapy for targeting the hormone regulated cancer with their clinical progress and clinical hurdles.
Название: Inflammation, Oxidative Stress, And ISBN: 1138199842 ISBN-13(EAN): 9781138199842 Издательство: Taylor&Francis Рейтинг: Цена: 12707.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Increasing scientific evidence suggests that the majority of diseases including cancer are driven by oxidative stress and inflammation, attributed to environmental factors. These factors either drive genetic mutations or epigenetically modify expression of key regulatory genes. These changes can occur as early as gestational fetal development, and major questions remain as to how dietary/nutritional phytochemical factors biochemically interact with such genetic and epigenetic events. With chapters written by international experts, Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention examines the latest developments on the effects of various dietary phytochemicals.
Divided into nine sections, the book begins with the basic mechanisms of inflammation/oxidative stress-driven cancer, including an overview of the topic and how to prevent carcinogenesis, the role of obesity in inflammation and cancer, and antioxidant properties of some common dietary phytochemicals. Subsequent sections cover cellular signal transduction, molecular targets, and biomarkers of dietary cancer-preventive phytochemicals, as well as their potential challenges with in vivo absorption and pharmacokinetics. The chapters also examine the cancer-preventive properties of various classes of phytochemicals, including vitamins A, D, and E; omega-3 and omega-6 fatty acids; flavanoids and polyphenols; garlic organosulfur compounds and cruciferous glucosinolates; and selenium, traditional Chinese herbal medicines, and alpha lipoic acid. The final section of the book explores the latest developments on the interactions of dietary phytochemicals through epigenetics and the management of chronic inflammation with nutritional phytochemicals.
Автор: Teresa Carlomagno Название: Tubulin-Binding Agents ISBN: 3642435947 ISBN-13(EAN): 9783642435942 Издательство: Springer Рейтинг: Цена: 44582.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year period is provided together with a compa- son of the different approaches. The third chapter describes a comprehensive study of the mechanisms of activity of microtubules stabilizing drugs. Thermodynamic, kinetic, structural and fu- tional data on microtubules stabilizing drugs are discussed in an interdisciplinary manner to generate a “time-resolved” picture of the interaction of the drugs with different tubulin forms. The fourth and fifth chapters review the efforts and achievements made in the characterization of the structure of the complexes of tubulin with microtubules stabilizing agents by NMR (Chapter 4) and EM (Chapter 5). Especially evident is the discrepancy of the results obtained for epothilones, where the two techniques deliver radically different structures of the bound drug. Both NMR and EM models are, however, able to explain a consistent set of SAR data. The authors of the two chapters discuss critically the advantages and limitations of each methodology.
Автор: Srivastava Sanjay K Название: Role of Capsaicin in Oxidative Stress and Cancer ISBN: 9400763166 ISBN-13(EAN): 9789400763166 Издательство: Springer Рейтинг: Цена: 19591.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress and much more.
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