Crossing the Boundaries of Life: Gьnter Blobel and the Origins of Molecular Cell Biology 9780226819341

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Автор: Matlin Karl S.
Название: Crossing the Boundaries of Life: Gьnter Blobel and the Origins of Molecular Cell Biology
ISBN: 9780226819341
Издательство: Wiley
Издательство: University of Chicago Press
Классификация:

История

История естественных наук

Молекулярная биология

Изобретения и изобретатели

ISBN-10: 0226819345
Обложка/Формат: Paperback
Страницы: 368
Вес: 0.54 кг.
Дата издания: 10.05.2022
Серия: Convening science: discovery at the marine biological laboratory
Язык: English
Иллюстрации: 38 halftones, 2 line drawings; 38 halftones, 2 line drawings
Размер: 22.86 x 15.24 x 2.08 cm
Читательская аудитория: Professional & vocational
Подзаголовок: Gunter blobel and the origins of molecular cell biology
Ссылка на Издательство: Link
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Поставляется из: США
Описание: A close look at Gьnter Blobels transformative contributions to molecular cell biology.

The difficulty of reconciling chemical mechanisms with the functions of whole living systems has plagued biologists since the development of cell theory in the nineteenth century. As Karl S. Matlin argues in Crossing the Boundaries of Life, it is no coincidence that this longstanding knot of scientific inquiry was loosened most meaningfully by the work of a cell biologist, the Nobel laureate Gьnter Blobel. In 1975, using an experimental setup that did not contain any cells at all, Blobel was able to target newly made proteins to cell membrane vesicles, enabling him to theorize how proteins in the cell distribute spatially, an idea he called the signal hypothesis. Over the next twenty years, Blobel and other scientists were able to dissect this mechanism into its precise molecular details. For elaborating his signal concept into a process he termed membrane topogenesis--the idea that each protein in the cell is synthesized with an address that directs the protein to its correct destination within the cell--Blobel was awarded the Nobel Prize in Physiology or Medicine in 1999.

Matlin argues that Blobels investigative strategy and its subsequent application addressed a fundamental unresolved dilemma that had bedeviled biology from its very beginning--the relationship between structure and function--allowing biology to achieve mechanistic molecular explanations of biological phenomena. Crossing the Boundaries of Life thus uses Blobels research and life story to shed light on the importance of cell biology for twentieth-century science, illustrating how it propelled the development of adjacent disciplines like biochemistry and molecular biology.

Crossing the Boundaries of Life: Gьnter Blobel and the Origins of Molecular Cell Biology, Matlin Karl S.