Alzheimer`s Disease Drug Development: Research and Development Ecosystem, Howard Fillit, Jefferson Kinney, Jeffrey Cummings
Автор: Rudolph Название: Alzheimer`s Disease ISBN: 1439827087 ISBN-13(EAN): 9781439827086 Издательство: Taylor&Francis Рейтинг: Цена: 17149.00 р. 24499.00-30% Наличие на складе: Есть (1 шт.) Описание:
In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer's disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer's Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD.
With contributions from experts drawn from academia, clinical practice, and the biotechnology and pharmaceutical industries, the book explores:
The basis of AD and the role of Aβ oligomers in development of disease
Existing and emerging in vitro biomarker-based methodologies for the diagnosis of AD, focusing on genetic, biochemical, and conformational strategies
In vivo imaging diagnostic approaches
Evolving diagnostic criteria, health regulatory guidelines, biomarkers in clinical trials, and available and emerging therapies
Recent progress in small-molecule disease-modifier drug discovery efforts for AD, specifically in the areas of Aβ, tau, and emerging neuroprotective/neurorepair approaches
How a case study of AD raises issues regarding clinical and pathologic criteria, risk factors, and the amyloid hypothesis
The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could represent new targets for disease-modifying therapies
The latest epidemiological, pathological, biochemical, and behavioral studies that may shed some light on the risk of developing AD and similar dementias after traumatic brain injury
Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.
Автор: Fisher Название: Advances in Alzheimer`s and Parkinson`s Disease ISBN: 038772074X ISBN-13(EAN): 9780387720746 Издательство: Springer Рейтинг: Цена: 43184.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Contains the proceedings of the 2005 ADPD conference. This title deals not only with issues related individually to Alzheimer`s disease and Parkinson`s disease, but also with the integration of these and other related diseases. It covers topics ranging from immunology, neuroscience, and pharmacology to genetics and molecular biology.
Автор: Atta-ur-Rahman Название: Drug Design and Discovery in Alzheimer`s Disease ISBN: 0128039590 ISBN-13(EAN): 9780128039595 Издательство: Elsevier Science Рейтинг: Цена: 15159.00 р. Наличие на складе: Поставка под заказ.
Описание:
Drug Design and Discovery in Alzheimer's Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of -amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery.
Edited and written by leading experts in Alzheimer's disease (AD) and other neurodegenerative disease drug development
Describes existing drugs for AD and current molecular understanding of the condition
Reviews recent advances in the field, including coverage of cholinesterases, BACE-1, and other drug development targets
Автор: Barton Cobert, William W. Gregory, Jean-Loup Thoma Название: Cobert`s Manual of Drug Safety and Pharmacovigilance. 3 Ed ISBN: 9811215235 ISBN-13(EAN): 9789811215230 Издательство: World Scientific Publishing Рейтинг: Цена: 8712.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Completely revised and updated, Cobert's Manual of Drug Safety and Pharmacovigilance, Third Edition, is a how-to manual for those working in the fields of drug safety, clinical research, pharmacology, regulatory affairs, risk management, quality/compliance, and in government and legal professions.
This comprehensive and practical guide discusses the theory and the practicalities of drug safety (also known as pharmacovigilance), and provides essential information on drug safety and regulations in the United States, Europe Union, and more, including: recognizing, monitoring, reporting, and cataloging serious adverse drug reactions.
Cobert's Manual of Drug Safety and Pharmacovigilance, Third Edition, teaches the daily practice of drug safety in industry, hospitals, the FDA and other health agencies -- both in the United States and around the world -- and provides critical information about what to do when confronted with a drug safety problem.
Автор: Anthea Innes, Debra Morgan, Jane Farmer Название: Remote and Rural Dementia Care: Policy, Research and Practice ISBN: 1447344952 ISBN-13(EAN): 9781447344957 Издательство: Marston Book Services Рейтинг: Цена: 16830.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This is the first comprehensive review of dementia research, policy and practice in remote and rural settings. Drawing on case studies from the UK, Australia, Europe and North America, it sets out the unique needs of sufferers and carers in isolated locations, and identifies areas for future research and improvements in dementia services.
Описание: Recent advances in genetics and brain biochemistry point to the Abeta peptide as the major culprit in causing neurodegeneration in Alzheimer’s Disease (AD). Abeta Peptide and Alzheimer’s Disease is specifically targeted at summarizing current knowledge of the Abeta peptide and its role in AD. Written by leaders in the industrial and academic world specializing in this rapidly moving area, the book covers fundamental biochemical studies on this peptide, the genetic impact on Abeta expression and processing, and various AD therapeutic strategies that target Abeta. Although specifically focusing on the Abeta peptide and AD, there is also some discussion on the similarity and differences of this peptide and AD with other amyloidogenic diseases, such as prion disease, Parkinsons and Huntingtons. This book will primarily be of interest to AD researchers and clinicians but also to researchers of other amyloid diseases.
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