Автор: Turksen Kursad Название: Permeability Barrier: Methods and Protocols ISBN: 1071616722 ISBN-13(EAN): 9781071616727 Издательство: Springer Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This detailed edition reflects the significant new findings in the components of permeability barriers and how they work in different tissues with a collection of cutting-edge techniques.
Описание: Life on Earth began some 4 billion years ago when the first primitive prokaryotes managed to isolate themselves from the rather hostile environment. The immediate challenge that these first life forms faced was to ensure an optimal balance between two apparently mutually exclusive tasks a protection and separation from the extracellular milieu on the one hand and an efficient exchange of ions, energy sources and metabolites with the very same milieu on the other hand. The commencing evolutionary progress had to address even more challenging problems, such as how to delegate specific cell functions to discrete structures inside of the cell, called organelles (such as the nucleus), and, at the level of multi-cellular organisms, to ensure proper separation of different cell types (e.g. those found in different tissues and organs) while ensuring efficient communication between them. In fact, the human body is highly compartmentalized, from the cell level where local signals are generated and propagated in a highly ordered manner, to the whole body level. This book aims to introduce the interested reader to the universe of these complex segregated compartments in mammals. It discusses how the integrity of different types of barriers a endothelial, epithelial a is normally maintained and what could go wrong when these barriers permeability becomes abnormally low or high in different disease states. We will focus on several such barriers, which are well studied and which are pivotal for a healthy well-being. In particular, we will focus on the skin, airways, the gut barrier, the endometrium, and cardiovascular and urinary systems. Special reference throughout the book will be made to several most novel groups of potential molecular candidates for the correction of barrier-related dysfunctions, in particular Transient Receptor Potential channels. Hence the title of the book has a triple meaning a a trip in its common sense, TRP channels (as in TRiP database) and Translating Research Into Practice (TRIP). Our team of authors is comprised of physiologists, pharmacologists, biophysicists and medics, including the national representative of Ukraine in the European Crohns and Colitis organization (ECCO) and a member of the Scientific Committee of the European Association of Urologists. We include clinical cases and discuss molecular and cellular mechanisms underlying such real-life problems in-depth.
Название: Cell Culture Models of Biological Barriers ISBN: 0367395959 ISBN-13(EAN): 9780367395957 Издательство: Taylor&Francis Рейтинг: Цена: 9798.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Over the past ten years several sophisticated in vitro test systems based on epithelial cell cultures have been introduced in the field of drug delivery. These models have been found to be very useful in characterizing the permeability of drugs across epithelial tissues, and in studying formulations or carrier systems for improved drug delivery and enhanced absorption. Compared to in vivo trials on animals or humans, cell culture models are faster, more convenient and cost effective, ethically advantageous and, most importantly, they can be more easily standardized and validated. This book provides a practical approach to contemporary cell culture-based in vitro techniques for drug transport studies at biological absorption barriers. It is an invaluable source of information for students attending graduate courses on this subject and pharmaceutical scientists working in industry or in academia.
Автор: Kursad Turksen Название: Permeability Barrier ISBN: 1493958623 ISBN-13(EAN): 9781493958627 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Methods in Molecular Biology (TM) book offers techniques for studying the Permeability Barrier. Includes lists of necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Автор: Thomsen Louiza Bohn Название: Gene Delivery to the Blood-Brain Barrier ISBN: 879298214X ISBN-13(EAN): 9788792982148 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 5885.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Ruth Lyck; Gaby Enzmann Название: The Blood Brain Barrier and Inflammation ISBN: 3319833081 ISBN-13(EAN): 9783319833088 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Поставка под заказ.
Описание: This PIR volume presents a comprehensive collection of reviews that focus on the role of the blood-brain barrier (BBB) during steady-state and inflamed conditions. Within the central nervous system (CNS) the constantly changing bloodstream is strictly separated from the CNS parenchyma by the BBB.
Автор: Paul J. Fairchild Название: The Immunological Barriers to Regenerative Medicine ISBN: 1489999329 ISBN-13(EAN): 9781489999320 Издательство: Springer Рейтинг: Цена: 21661.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume offers an analysis of the scale and nature of the immunological issues facing regenerative medicine, drawing on the expertise of laboratories around the world who have taken up the challenge of applying their expertise in immunology to the vagaries of stem cell biology. In Part I, we explore the extent to which the principles of allograft rejection, learned over several decades from our experiences of whole organ transplantation, apply within the unique context of cell replacement therapy. Part II discusses various innovative ways of addressing the issues of immunogenicity, while, in Part III, we focus exclusively on the induction of immunological tolerance through a variety of novel approaches. It is our hope that this systematic analysis of the current state of the field will galvanise efforts to solve an issue which has so far remained intractable.
Автор: Gorbunov, Nikolai V. Название: Tissue Barriers In Disease, Injury And Regeneration ISBN: 0128185619 ISBN-13(EAN): 9780128185612 Издательство: Elsevier Science Рейтинг: Цена: 19875.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Tissue Barriers in Disease, Injury and Regeneration focuses on the molecular and cellular fundamentals of homeostatic and defense responses of tissue barriers, covering the damaging impacts and exposure to pathogens and engineered nanomaterials. Sections emphasize the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells, along with reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and metabolic status. Other sections cover the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, vasculature of blood-tissue barriers, and more.
Includes special emphasis on the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells in the development of reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and in metabolic status
Examines the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, the vasculature of blood-tissue barriers, and mucosa and external epithelium
Автор: Burkheisser, Ernest V. Название: Biological barriers to cellulosic ethanol ISBN: 1606922033 ISBN-13(EAN): 9781606922033 Издательство: Nova Science Рейтинг: Цена: 7760.00 р. Наличие на складе: Невозможна поставка.
Описание: Defines barriers and challenges to a rapid expansion of cellulosic-ethanol production and determine ways to speed solutions through concerted application of modern biology tools as part of a joint research agenda.
Автор: Bruno Filipe Carmelino Ca Название: Concepts and models for drug permeability studies ISBN: 0081000944 ISBN-13(EAN): 9780081000946 Издательство: Elsevier Science Рейтинг: Цена: 24423.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book intends to be an updated compilation of the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, skin and blood-brain barrier in vitro models for predicting the permeability of drugs. Concepts and Models for Drug Permeability Studies focuses on different approaches and comprises of various models. Each model describes the protocol of seeding and conservation, the application for specific drugs, and takes into account the maintenance of physiologic characteristics and functionality of epithelium, from the simplest immortalized cell-based monoculture to the most complex engineered-tissue models. Chapters also discuss the equivalence between in vitro cell and tissue models and in vivo conditions, highlighting how each model may provisionally resemble a different drug absorption route.
Автор: Banfalvi Название: Permeability of Biological Membranes ISBN: 3319802712 ISBN-13(EAN): 9783319802718 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Поставка под заказ.
Описание: This book deals with biological membranes, focuses on permeabilization and pays particular attention to reversible permeabilization to maintain the viability and physiological conditions of the cells. Selective permeability of biological membranes also known as semipermeability, partial permeability or differential permeability allows molecules to diffuse, pass by passive and active or by other types of transport processes mediated by proteins. The first chapter of the book deals with the composition of biological membranes, characterizes cellular membranes of prokaryotic, eukaryotic cells, membranes of cellular organelles and the function of biological membranes. The second chapter provides an overview of bilayer permeability, selectivity of permeabilization and cellular transport processes. Chapter 3 overviews different cell manipulations that aim to make cells permeable while maintaining not only the structural but also the functional integrity of cells. The last chapter deals with applications, particularly with reversible permeabilization to study macromolecular (DNA, RNA, poly-ADP ribose) biosynthetic processes, replication, gene expression, visualization of replicons, intermediates of chromosome condensation, genotoxic chromatin changes, upon treatment with heavy metals and different types of irradiation. The interdisciplinary aspects of the book contribute to the understanding of the structure of nucleic acids, replicative intermediates, Okazaki fragments, RNA primer mechanism, subphases of replication and repair synthesis, replicons, gene expression, chromosome condensation generated a wealth of information that will attract a wide readership. The natural audience engaged in DNA research, including genetics, cell and molecular biology, chemistry, biochemistry, medicine, pharmacy will find essential material in the book.
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