Автор: Soney C. George, Ann Rose Abraham Название: Nanotechnology platforms for antiviral challenges : ISBN: 1032152303 ISBN-13(EAN): 9781032152301 Издательство: Taylor&Francis Рейтинг: Цена: 18374.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book discusses the utilization of nano-based formulations for control of viral agents. Antiviral potential of green synthesized silver, chitosan nanoparticles encapsulating curcumin, photoinduced antiviral carbon nanohorns, and role of carbon-based materials like fullerenes &carbon nanotubes in repression of viral antigens are explained.
Автор: Erik De Clercq; Richard T. Walker Название: Antiviral Drug Development ISBN: 1468472771 ISBN-13(EAN): 9781468472776 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Edwin Yunhao Gong Название: Antiviral Methods and Protocols ISBN: 1493960350 ISBN-13(EAN): 9781493960354 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Part I: Human Immunodeficiency Virus Type 1 (HIV-1)
1. A Fluorescence-Based High Throughput Screening Assay to Identify HIV-1 Inhibitors
Peggy Geluykens, Koen Van Acker, Johan Vingerhoets, Christel Van den Eynde, Marnix Van Loock, and Gйry Dams
2. A Homogeneous Time-Resolved Fluorescence Assay to Identify Inhibitors of HIV-1 Fusion
Liesbet Smeulders, Lieve Bunkens, Inge Vereycken, Koen Van Acker, Pascale Holemans, Emmanuel Gustin, Marnix Van Loock, and Gйry Dams
3. Identification of HIV-1 Reverse Transcriptase Inhibitors Using a Scintillation Proximity Assay
Bertrand Van Schoubroeck, Marnix Van Loock, Tania Ivens, Pascale Dehertogh, Dirk Jochmans, and Gйry Dams
4. Biochemical Screening Assays to Identify HIV-1 Integrase Inhibitors
Marleen Clynhens, Alexandra Smets, Inge Vereycken, Marnix Van Loock, Reginald Clayton, Geert Meersseman, and Olivia Goethals
5. HIV-1 Genotyping of the Protease-Reverse Transcriptase and Integrase Genes to Detect Mutations that Confer Anti-Retroviral Resistance
Peter Van den Eede, Liesbeth Van Wesenbeeck, Yvan Verlinden, Maxim Feyaerts, Veerle Smits, Ann Verheyen, Leen Vanhooren, Alain Deloof, Jorge Villacian, and Theresa Pattery
Part II: Hepatitis Viruses
6. In Vitro Kinetic Profiling of Hepatitis C Virus NS3 Protease Inhibitors by Progress Curve Analysis
Rumin Zhang and William T. Windsor
7. A Novel Hepatitis C Virus NS5B Polymerase Assay of De Novo Initiated RNA Synthesis Directed from a Heteropolymeric RNA Template
Eric Ferrari and Hsueh-Cheng Huang
8. Selecting and Characterizing Drug-Resistant Hepatitis C Virus Replicon
Inge Vliegen, Leen Delang, and Johan Neyts
9. A Cellular Replicon-Based Phenotyping Assay to Determine Susceptibility of Hepatitis C Virus Clinical Isolates to NS3/4A Protease Inhibitors
Leen Vijgen, Jannick Verbeeck, Barbara Van Kerckhove, Jan Martin Berke, Diana Koletzki, Gregory Fanning, and Oliver Lenz
10. Expression and Purification of Hepatitis C Virus Protease from Clinical Samples
Liesbet van der Helm
11. Surface Plasmon Resonance as a Tool to Select Potent Drug Candidates for Hepatitis C Virus NS5B Polymerase
Erna Cleiren, Benoit Devogelaere, and Katleen Fierens
12. Amplification and Sequencing of the Hepatitis C Virus NS3/4A Protease and the NS5B Polymerase Regions for Genotypic Resistance Detection of Clinical Isolates of Subtypes 1a and 1b
Diana Koletzki, Theresa Pattery, Bart Fevery, Leen Vanhooren, and Lieven J. Stuyver
13. A Southern Blot Assay for Detection of Hepatitis B Virus Covalently Closed Circular DNA from Cell Cultures
Dawei Cai, Hui Nie, Ran Yan, Ju-Tao Guo, Timothy M. Block, and Haitao Guo
14. In Vitro Phenotyping of Recombinant Hepatitis B Virus Containing the Polymerase/Reverse Transcriptase Gene from Clinical Isolates
Yang Liu and Kathryn M. Kitrinos
Part III: Flaviviruses
15. Cell-Based Antiviral Assays for Screening and Profiling Inhibitors Against Dengue Virus
Edwin Yunhao Gong, Marleen Clynhens, Tania Ivens, Pedro Lory, Kenny Simmen, and Guenter Kraus
16. A Duplex Real-Time RT-PCR Assay for Profiling Inhibitors of Four Dengue Serotypes
Edwin Yunhao Gong, Alexandra Smets, Nick Verheyen, Marleen Clynhens, Emmanuel Gustin, Pedro Lory, and Guenter Kraus
17. High Throughput Screening Using Dengue Virus Reporter Genomes
Wolfgang Fischl and Ralf Bartenschlager
18. Fluorimetric and HPLC-Based Dengue Virus Protease Assays Using a FRET Substrate
Christoph Ni
Автор: John Mills; Paul A. Volberding; Lawrence Corey Название: Antiviral Chemotherapy 4 ISBN: 0306452944 ISBN-13(EAN): 9780306452949 Издательство: Springer Рейтинг: Цена: 34799.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the Fourth Triennial Symposium held in San Francisco,California, November 10-12, 1994.
Название: Antiviral agents, vaccines, and immunotherapies ISBN: 0367393743 ISBN-13(EAN): 9780367393748 Издательство: Taylor&Francis Рейтинг: Цена: 9492.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Providing an analysis of the benefits and limitations of every available drug, vaccine and immunotherapy used to control and prevent antiviral diseases, this unique and genuinely comprehensive text is unlike any other current reference of its kind.
Автор: D.C. Baker; C.K. Chu Название: Nucleosides and Nucleotides as Antitumor and Antiviral Agents ISBN: 1461362210 ISBN-13(EAN): 9781461362210 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: More remarkably, the discovery of the chemotherapeutic agent AZT (Retrovir) was made within two years after the isolation and identification of the virus, followed by unprecedented drug development efforts to culminate in the FDA approval of AZT in twenty-three months, which was a record-breaking time for approval of any drug for a major disease.
Автор: Sandler Eva Название: Advanced Antiviral Drugs and Clinical Approaches ISBN: 1632420198 ISBN-13(EAN): 9781632420190 Издательство: Неизвестно Цена: 18346.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Edwin Yunhao Gong Название: Antiviral Methods and Protocols ISBN: 1627034838 ISBN-13(EAN): 9781627034838 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Part I: Human Immunodeficiency Virus Type 1 (HIV-1)
1. A Fluorescence-Based High Throughput Screening Assay to Identify HIV-1 Inhibitors
Peggy Geluykens, Koen Van Acker, Johan Vingerhoets, Christel Van den Eynde, Marnix Van Loock, and Gйry Dams
2. A Homogeneous Time-Resolved Fluorescence Assay to Identify Inhibitors of HIV-1 Fusion
Liesbet Smeulders, Lieve Bunkens, Inge Vereycken, Koen Van Acker, Pascale Holemans, Emmanuel Gustin, Marnix Van Loock, and Gйry Dams
3. Identification of HIV-1 Reverse Transcriptase Inhibitors Using a Scintillation Proximity Assay
Bertrand Van Schoubroeck, Marnix Van Loock, Tania Ivens, Pascale Dehertogh, Dirk Jochmans, and Gйry Dams
4. Biochemical Screening Assays to Identify HIV-1 Integrase Inhibitors
Marleen Clynhens, Alexandra Smets, Inge Vereycken, Marnix Van Loock, Reginald Clayton, Geert Meersseman, and Olivia Goethals
5. HIV-1 Genotyping of the Protease-Reverse Transcriptase and Integrase Genes to Detect Mutations that Confer Anti-Retroviral Resistance
Peter Van den Eede, Liesbeth Van Wesenbeeck, Yvan Verlinden, Maxim Feyaerts, Veerle Smits, Ann Verheyen, Leen Vanhooren, Alain Deloof, Jorge Villacian, and Theresa Pattery
Part II: Hepatitis Viruses
6. In Vitro Kinetic Profiling of Hepatitis C Virus NS3 Protease Inhibitors by Progress Curve Analysis
Rumin Zhang and William T. Windsor
7. A Novel Hepatitis C Virus NS5B Polymerase Assay of De Novo Initiated RNA Synthesis Directed from a Heteropolymeric RNA Template
Eric Ferrari and Hsueh-Cheng Huang
8. Selecting and Characterizing Drug-Resistant Hepatitis C Virus Replicon
Inge Vliegen, Leen Delang, and Johan Neyts
9. A Cellular Replicon-Based Phenotyping Assay to Determine Susceptibility of Hepatitis C Virus Clinical Isolates to NS3/4A Protease Inhibitors
Leen Vijgen, Jannick Verbeeck, Barbara Van Kerckhove, Jan Martin Berke, Diana Koletzki, Gregory Fanning, and Oliver Lenz
10. Expression and Purification of Hepatitis C Virus Protease from Clinical Samples
Liesbet van der Helm
11. Surface Plasmon Resonance as a Tool to Select Potent Drug Candidates for Hepatitis C Virus NS5B Polymerase
Erna Cleiren, Benoit Devogelaere, and Katleen Fierens
12. Amplification and Sequencing of the Hepatitis C Virus NS3/4A Protease and the NS5B Polymerase Regions for Genotypic Resistance Detection of Clinical Isolates of Subtypes 1a and 1b
Diana Koletzki, Theresa Pattery, Bart Fevery, Leen Vanhooren, and Lieven J. Stuyver
13. A Southern Blot Assay for Detection of Hepatitis B Virus Covalently Closed Circular DNA from Cell Cultures
Dawei Cai, Hui Nie, Ran Yan, Ju-Tao Guo, Timothy M. Block, and Haitao Guo
14. In Vitro Phenotyping of Recombinant Hepatitis B Virus Containing the Polymerase/Reverse Transcriptase Gene from Clinical Isolates
Yang Liu and Kathryn M. Kitrinos
Part III: Flaviviruses
15. Cell-Based Antiviral Assays for Screening and Profiling Inhibitors Against Dengue Virus
Edwin Yunhao Gong, Marleen Clynhens, Tania Ivens, Pedro Lory, Kenny Simmen, and Guenter Kraus
16. A Duplex Real-Time RT-PCR Assay for Profiling Inhibitors of Four Dengue Serotypes
Edwin Yunhao Gong, Alexandra Smets, Nick Verheyen, Marleen Clynhens, Emmanuel Gustin, Pedro Lory, and Guenter Kraus
17. High Throughput Screening Using Dengue Virus Reporter Genomes
Wolfgang Fischl and Ralf Bartenschlager
18. Fluorimetric and HPLC-Based Dengue Virus Protease Assays Using a FRET Substrate
Among infectious diseases, viral infections are the leading cause of death worldwide, especially in the most low-income countries, particularly in young children. Most of the human viruses are all well characterized in terms of structure, life-cycle, tropism, and associated primary pathologies, but many of the pathogenetic mechanisms underlying their ability to cause acute infection, persist or reactivate in the host and cause chronic and/or degenerative damage, and still need to be fully clarified. At the same time, it seems necessary to develop novel therapeutic approaches and rationale, and possibly more potent antiviral compounds that are addressed to novel targets.
Автор: Driscoll Название: Antiviral Drugs.2004 ISBN: 0566083108 ISBN-13(EAN): 9780566083105 Издательство: Wiley Цена: 8546.00 р. Наличие на складе: Поставка под заказ.
Описание: Viruses are microorganisms that are as varied in type as the plants and animals of the macroscopic world. A particularly virulent virus can infect and kill a human host, which is 10 million times larger. The human immune system is the first line of defense against any infectious organism. However, sometimes this protection proves inadequate to the viral challenge. In this situation humans attempt to provide additional aid in retarding viral reproduction through the use of antiviral drugs until an overwhelmed immune system is able to cope with the infection. This type of self-help is the object of antiviral drug research. "Antiviral Drugs" by John Driscoll provides up-to-date information on the classification, history, structure, preclinical development, bioactivity, pharmacology, and effectiveness of the 72 most important antiviral agents. A carefully researched collectionover 400 references places details of definitive recent antiviral research at the reader's fingertips. An appendix contains for each drug an at-a-glance, detailed sketch, which includes chemical structure and molecular formula, identification numbers, synonyms, physical properties, toxicities, and manufacturers. Introductory chapters describe where viruses fit into the world of microorganisms, explore the unique properties of DNA and RNA viruses, and show how new antiviral drugs are discovered and developed into useful medicines.
Автор: John Mills; Paul A. Volberding; Lawrence Corey Название: Antiviral Chemotherapy 5 ISBN: 1461371503 ISBN-13(EAN): 9781461371502 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Scientists and clinicians attending the last "New Directions in Antiviral Therapy" conference in late 1994 could hardly have predicted the revolution in the management of patients with HIV infection that has occurred since.
Автор: MERLUZZI; ADAMS Название: The Search for Antiviral Drugs ISBN: 1489967206 ISBN-13(EAN): 9781489967206 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
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