Описание: Fully updated, tracing the evolution of jazz and blues from their nineteenth-century African-American origins right through to the present day. Key musical developments within each era are covered, as well as an A-Z of key artists; sections on Styles and Instruments also included. Written by a team of experts. Comprehensive and easy to use.
Описание: Splendid, monumental reference work, authoritative and lavishly illustrated
More than 400 distinguished scholars, including archaeologists, art historians, historians, epigraphers, and theologians, have written the 1,455 entries in this monumental encyclopedia--the first comprehensive reference work of its kind.
From Aachen to Zurzach, Paul Corby Finney's three-volume masterwork draws on archaeological and epigraphic evidence to offer readers a basic orientation to early Christian architecture, sculpture, painting, mosaic, and portable artifacts created roughly between AD 200 and 600 in Africa, Asia, and Europe.
Clear, comprehensive, and richly illustrated, this work will be an essential resource for all those interested in late antique and early Christian art, archaeology, and history.
End of Days: An Encyclopedia of the Apocalypse in World Religions describes apocalyptic writings in the world's major religious traditions, including Judaism, Christianity, Islam, Hinduism, and Buddhism. The cross-referenced entries address ancient traditions--Zoroastrianism, as one example--as well as modern apocalyptic movements, such as Arun Shinrikyo, the Branch Davidians, and the Order of the Solar Temple.
This book's broad scope offers coverage of overlooked traditions, such as Mayan Apocalyptic, Norse Apocalyptic, Native American eschatological literatures, and the Tibetan Book of the Dead. Readers seeking detailed information on the eschatological and apocalyptic movements and proponents of End Times can reference entries about individuals such as Harold Camping, Jerry Falwell, David Koresh of the Brand Davidians, and James Jones and the People's Temple.
This single-volume encyclopedia also contains numerous historical entries on subjects such as the Great Disappointment, the Great Awakening periods of religious revival, Joachim of Flora, the Maccabean Revolt, and the Plymouth Brethren. The influence of apocalyptic ideas far outside the realm of religion itself is documented through entries on film, including well-known modern movies such as The Hunger Games and Apocalypse Now, literature by writers such as Dante, and works of fine art like Wagner's G tterd mmerung. The inclusion of entries related to literature, film, and other art forms further attests to the wide-ranging social influence of belief in the end of days.
Автор: Dale, Cyndi Название: Subtle body ISBN: 1591796717 ISBN-13(EAN): 9781591796718 Издательство: Holtzbrink(MPS)/MPS Рейтинг: Цена: 4883.00 р. Наличие на складе: Ожидается поступление.
Описание: Welcome to the first comprehensive encyclopedia of the human energetic anatomy. Here is a reference that no personal or professional health-care library should be without an in-depth, illustrated guide to the invisible energies of the spirit, psyche, and consciousness that influence every aspect of our well-being. Whether you are looking for the ri
Автор: Zanini De Vita, Oretta Название: Encyclopedia of pasta ISBN: 0520255224 ISBN-13(EAN): 9780520255227 Издательство: Wiley Рейтинг: Цена: 6019.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Spaghetti, gnocchi, tagliatellea, ravioli, vincisgrassi, strascinati - pasta in its myriad forms has been a staple of the Mediterranean diet longer than bread. This book provides a history of pasta in Italy, telling its long story via the extravagant variety of shapes it takes and the even greater abundance of names by which it is known.
Автор: Fath, Brian Название: Encyclopedia of Ecology ISBN: 0444637680 ISBN-13(EAN): 9780444637680 Издательство: Elsevier Science Рейтинг: Цена: 265280.00 р. Наличие на складе: Поставка под заказ.
Описание:
Encyclopedia of Ecology, Second Edition, Four Volume Set continues the acclaimed work of the previous edition published in 2008. It covers all scales of biological organization, from organisms, to populations, to communities and ecosystems. Laboratory, field, simulation modelling, and theoretical approaches are presented to show how living systems sustain structure and function in space and time. New areas of focus include micro- and macro scales, molecular and genetic ecology, and global ecology (e.g., climate change, earth transformations, ecosystem services, and the food-water-energy nexus) are included. In addition, new, international experts in ecology contribute on a variety of topics.
Описание: Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. This two volume set of books comprehensively reviews current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics. The second volume is specifically dedicated to emerging science and technologies, highlighting potential areas for future advances within the drug transporter field. The topics covered in this set of books ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and preclinical tools through to the potential impact of transporters in the clinic. Contributions are included from expert leaders in the field, at-the-bench industrial scientists, renowned academics and international regulators. Case studies and emerging developments are highlighted, together with the merits and limitations of the available methods and tools, and extensive references to reviews on specific in-depth topics are also included for those wishing to pursue their knowledge further. As such, this text serves as an essential handbook of information for postgraduate students, academics, industrial scientists and regulators who wish to understand the role of transporters in absorption, distribution, metabolism, and excretion processes. In addition, it is also a useful reference tool on the models and calculations necessary to predict their effect on human pharmacokinetics and pharmacodynamics.
Описание: Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. As an introduction oriented to pharmacy students, it is also written for scientist from different fields outside of pharmaceutics. (e.g. material scientist, material engineers, medicinal chemists) who might be working in a positions in pharmaceutical companies or whose work might benefit from basic training in the ADME concepts and some biological background. Pedagogical features such as objectives, keywords, discussion questions, summaries and case studies add valuable teaching tools. This book will provide not only general knowledge on ADME processes but also an updated insight on some hot topics such as drug transporters, multi-drug resistance related to pharmacokinetic phenomena, last generation pharmaceutical carriers (nanopharmaceuticals), in vitro and in vivo bioequivalence studies, biopharmaceuticals, pharmacogenomics, drug-drug and food-drug interactions, and in silico and in vitro prediction of ADME properties. In comparison with other similar textbooks, around half of the volume would be focused on the relationship between expanding scientific fields and ADME processes. Each of these burgeoning fields has a separate chapter in the second part of the volume, and was written with leading experts on the correspondent topic, including scientists and academics from USA and UK (Duquesne University School of Pharmacy, Indiana University School of Medicine, University of Utah College of Pharmacy, University of Maryland, University of Bath).Additionally, each of the initial chapters dealing with the generalities of drug absorption, distribution, metabolism and excretion would include relevant, classic examples related to each topic with appropriate illustrations (e.g. importance of active absorption of levodopa, implications in levodopa administration, drug drug interactions and food drug interactions emerging from the active uptake; intoxication with paracetamol as a result of glutathione depletion, CYP induction and its relationship with acute liver failure caused by paracetamol, etc).ADME Processes and Pharmaceutical Sciences is written as a core textbook for ADME processes, pharmacy, pharmacokinetics, drug delivery, biopharmaceutics, drug disposition, drug design and medicinal chemistry courses.
Автор: Li Di Название: Drug-like Properties ISBN: 0128010762 ISBN-13(EAN): 9780128010761 Издательство: Elsevier Science Рейтинг: Цена: 26444.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property.
Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization.
Описание: This book comprehensively reviews current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics.
Описание: By guiding in the application of techniques and tools for predicting ADMET outcomes in drug candidates, Predictive ADMET offers a road map for drug discovery scientists to generate effective and safe drugs for unmet medical needs.
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