Cancer Drug Discovery, Kim

Название: Hypoxia and Cancer
ISBN: 1461491665 ISBN-13(EAN): 9781461491668
Издательство: Springer
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Описание: ГЇВїВЅ ГЇВїВЅ ГЇВїВЅ The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues.

Автор: Gurmit Singh; Shafaat A. Rabbani
Название: Bone Metastasis
ISBN: 1617375454 ISBN-13(EAN): 9781617375453
Издательство: Springer
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Описание: The authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover.

Автор: L. Harivardhan Reddy; Patrick Couvreur
Название: Macromolecular Anticancer Therapeutics
ISBN: 1441905065 ISBN-13(EAN): 9781441905062
Издательство: Springer
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Описание: Cancer treatment using Macromolecular therapeutics has considerably improved the survival benefit for the patients. This book assembles various types and aspects of macromolecular anticancer therapeutics for cancer therapy and conveys the importance of this interdisciplinary field.

Автор: Mary L. Disis
Название: Immunotherapy of Cancer
ISBN: 1617376450 ISBN-13(EAN): 9781617376450
Издательство: Springer
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Описание: Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments.

Автор: Gary J. Kelloff; Ernest T. Hawk; Caroline C. Sigma
Название: Cancer Chemoprevention
ISBN: 1627038175 ISBN-13(EAN): 9781627038171
Издательство: Springer
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Цена: 39130.00 р.
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Описание: Despite significant advances in cancer treatment and measures of neoplastic progression, drug effect (or early detection, overall cancer incidence has increased, pharmacodynamic markers), and markers that measure cancer-associated morbidity is considerable, and overall prognosis as well as predict responses to specific therapy. cancer survival has remained relatively flat over the past All these biomarkers have the potential to greatly augment several decades (1,2). However, new technology the development of successful chemoprevention therapies, allowing exploration of signal transduction pathways, but two specific types of biomarkers will have the most identification of cancer-associated genes, and imaging of immediate impact on successful chemopreventive drug tissue architecture and molecular and cellular function is development—those that measure the risk of developing increasing our understanding of carcinogenesis and cancer invasive life-threatening disease, and those whose mo- progression. This knowledge is moving the focus of cancer lation can “reasonably predict” clinical benefit and, therapeutics, including cancer preventive treatments, to therefore, serve as surrogate endpoints for later-occurring drugs that take advantage of cellular control mechanisms clinical disease. Thus far, the biomarker that best measures to selectively suppress cancer progression. these two phenomena is intraepithelial neoplasia (IEN) Carcinogenesis is now visualized as a multifocal, because it is a near obligate precursor to cancer.

Автор: Giampietro Gasparini; Daniel F. Hayes
Название: Biomarkers in Breast Cancer
ISBN: 1617374369 ISBN-13(EAN): 9781617374364
Издательство: Springer
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Цена: 34799.00 р.
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Описание: Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators.

Автор: Eric Verdin
Название: Histone Deacetylases
ISBN: 1617376027 ISBN-13(EAN): 9781617376023
Издательство: Springer
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Описание: A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression.

Автор: Godefridus J Peters
Название: Deoxynucleoside Analogs in Cancer Therapy
ISBN: 1617374970 ISBN-13(EAN): 9781617374975
Издательство: Springer
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Описание: The classical example is gemcitabine, now one of the most widely applied deoxynucleoside analogs, used for the (combination) treatment of non-small cell lung cancer, pancreatic cancer, bladder cancer, and ovarian cancer.

Автор: Michael A. Caligiuri; Michael T. Lotze
Название: Cytokines in the Genesis and Treatment of Cancer
ISBN: 161737203X ISBN-13(EAN): 9781617372032
Издательство: Springer
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Описание: Cytokines in the Genesis and Treatment of Cancer provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression. This volume represents an important investigation into the emerging intersection of cancer biology and cancer immunology.

Автор: Peter M. Schlag; M.M. Eggermont; Ulrike S. Stein
Название: Regional Cancer Therapy
ISBN: 1617377112 ISBN-13(EAN): 9781617377112
Издательство: Springer
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Описание: This volume provides a biological and pharmacological background for regional cancer therapy, strategies and techniques for regional therapies, and specific indications and results for different tumor entities.

Автор: C.-H. Heldin; Sonia B. Jakowlew
Название: Transforming Growth Factor-Beta in Cancer Therapy, Volume II
ISBN: 1617377368 ISBN-13(EAN): 9781617377365
Издательство: Springer
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Цена: 38992.00 р.
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Описание: Transforming Growth Factor- ss in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ss (TGF- ss) in cancer treatment and therapy. The companion volume details the role of TGF- ss on basic and clinical biology.

Автор: Wei Dai
Название: Checkpoint Responses in Cancer Therapy
ISBN: 161737847X ISBN-13(EAN): 9781617378478
Издательство: Springer
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Цена: 28732.00 р.
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Описание: Checkpoint Responses in Cancer Therapy summarizes the advances made over the past 20 years, identifying components of cell-cycle checkpoints and their molecular regulation during checkpoint activation and validating the use of checkpoint proteins as targets for the development of anticancer drugs.