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Stem Cells in Modeling Human Genetic Diseases, Zatz


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Автор: Zatz
Название:  Stem Cells in Modeling Human Genetic Diseases
ISBN: 9783319371160
Издательство: Springer
Классификация:


ISBN-10: 3319371169
Обложка/Формат: Soft cover
Страницы: 147
Вес: 2.82 кг.
Дата издания: 05.11.2016
Серия: Stem Cell Biology and Regenerative Medicine
Язык: English
Издание: Softcover reprint of
Иллюстрации: 4 tables, black and white; 15 illustrations, color; 1 illustrations, black and white; xii, 147 p. 16 illus., 15 illus. in color.
Размер: 235 x 155
Читательская аудитория: General (us: trade)
Основная тема: Life Sciences
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: While most stem cell books focus on basic aspects and/or cell therapy, this book emphasizes the relevance of stem cells obtained from patients, the so-called “patients in a petri dish” as tools to investigate human genetic diseases for which there are no available effective treatment. Chapters embrace several examples of the use of iPS cell technology, a recent Nobel Prize-winning scientific breakthrough, to obtain patient-specific pluripotent cells from which many types of specialized cells involved in a particular disease can be generated, including psychiatric and neurodegenerative disorders, muscular dystrophies, laminopathies, among others. The text is a current and timely resource for postgraduate students, scientists and clinicians, interested in applications of this rapidly developing field of research in disease modeling, drug development, and emerging issues that it brings to regenerative medicine.
Дополнительное описание: Modeling Fragile X Syndrome in Human Pluripotent Cells.- Induced Pluripotent Stem Cells in Familial Dilated Cardiomyopathy.- Induced Pluripotent Stem Cells and Amyotrophic Lateral Sclerosis.- IPS Cells and Spinocerebellar Ataxia.- Induced Pluripotent Stem



Molecular Diagnosis of Genetic Diseases

Автор: Rob Elles
Название: Molecular Diagnosis of Genetic Diseases
ISBN: 1617372595 ISBN-13(EAN): 9781617372599
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This completely revised and updated second edition to integrates the many new technologies and insights now available for the diagnosis of genetic diseases.

Genetic Diseases of the Kidney,

Автор: Richard P. Lifton
Название: Genetic Diseases of the Kidney,
ISBN: 0124498515 ISBN-13(EAN): 9780124498518
Издательство: Elsevier Science
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Цена: 15091.00 р. 21559.00 -30%
Наличие на складе: Есть (1 шт.)
Описание: Genetic approaches have revolutionized our understanding of the fundamental causes of human disease by permitting the identification of specific genes in which variation causes or contributes to disease. This book offers an insight into the role of genetic abnormalities in the pathogenesis of abnormal kidney function and kidney disease.

Handbook of Stem Cells, vol.1-2

Автор: Anthony Atala
Название: Handbook of Stem Cells, vol.1-2
ISBN: 0123859425 ISBN-13(EAN): 9780123859426
Издательство: Elsevier Science
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Цена: 29722.00 р.
Наличие на складе: Есть (2 шт.)
Описание: Offers a description of the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations. This title also offers advanced information of what is known about each specific organ system.

Stem Cells and Human Diseases

Автор: Rakesh K. Srivastava; Sharmila Shankar
Название: Stem Cells and Human Diseases
ISBN: 940178471X ISBN-13(EAN): 9789401784719
Издательство: Springer
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Цена: 32651.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: The main objective of this book is to provide a comprehensive review on stem cells and their role in tissue regeneration, homeostasis and therapy. The cell signaling pathways and microRNA regulating stem cell self-renewal, tissue homeostasis and drug resistance are also mentioned.

Principles and Advances in Human Genetics: A Primer on Genetic Disorders

Автор: Cheryl Natividad
Название: Principles and Advances in Human Genetics: A Primer on Genetic Disorders
ISBN: 1774077604 ISBN-13(EAN): 9781774077603
Издательство: Mare Nostrum (Eurospan)
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Цена: 22730.00 р.
Наличие на складе: Нет в наличии.

Описание: Many of the fundamental concepts in genetics are applicable across various organisms - microorganisms, plants, animals, and humans. This book presents a concise discussion of these universal genetic principles. In addition, the book also spotlights an aspect of genetics that is distinctly human - genetic disorders.

Cellular Biophysics and Modeling: A Primer on the Computational Biology of Excitable Cells

Автор: Greg Conradi Smith
Название: Cellular Biophysics and Modeling: A Primer on the Computational Biology of Excitable Cells
ISBN: 1107005361 ISBN-13(EAN): 9781107005365
Издательство: Cambridge Academ
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Цена: 15046.00 р.
Наличие на складе: Поставка под заказ.

Описание: What every neuroscientist should know about the mathematical modeling of excitable cells. Combining empirical physiology and nonlinear dynamics, this text provides an introduction to the simulation and modeling of dynamic phenomena in cell biology and neuroscience. It introduces mathematical modeling techniques alongside cellular electrophysiology. Topics include membrane transport and diffusion, the biophysics of excitable membranes, the gating of voltage and ligand-gated ion channels, intracellular calcium signalling, and electrical bursting in neurons and other excitable cell types. It introduces mathematical modeling techniques such as ordinary differential equations, phase plane, and bifurcation analysis of single-compartment neuron models. With analytical and computational problem sets, this book is suitable for life sciences majors, in biology to neuroscience, with one year of calculus, as well as graduate students looking for a primer on membrane excitability and calcium signalling.

T Regulatory Cells in Human Health and Diseases

Автор: Zheng Song-Guo
Название: T Regulatory Cells in Human Health and Diseases
ISBN: 981156406X ISBN-13(EAN): 9789811564062
Издательство: Springer
Цена: 25155.00 р.
Наличие на складе: Поставка под заказ.

Описание: This book is intended for periodontal residents and practicing periodontists who wish to incorporate the principles of moderate sedation into daily practice. Comprehensive airway management and rescue skills are then documented in detail so that the patient may be properly managed in the event that the sedation progresses beyond the intended level.

Genetic Engineering of Mesenchymal Stem Cells

Автор: Jan A. Nolta
Название: Genetic Engineering of Mesenchymal Stem Cells
ISBN: 9048169992 ISBN-13(EAN): 9789048169993
Издательство: Springer
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Цена: 23508.00 р.
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Описание: MSC (mesenchymal stem cells) have been reported to initiate revascularization after injury, to facilitate engraftment of blood-forming stem cells, and to reduce the incidence of graft-vs.

Stem Cells for Cancer and Genetic Disease Treatment

Автор: Phuc Van Pham; Ahmed El-Hashash
Название: Stem Cells for Cancer and Genetic Disease Treatment
ISBN: 3319980645 ISBN-13(EAN): 9783319980645
Издательство: Springer
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Цена: 20962.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This invaluable resource discusses insights ranging from basic biological mechanisms of various types of stem cells through the potential applications in the treatment of human diseases, including cancer and genetic disorders. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in understanding different types of stem cell biology and their potential applications in tissue repair and regeneration and in the treatment different types of human cancer and genetic diseases or disorders. Stem Cells for Cancer and Genetic Disease Treatment and the other books in the Stem Cells in Clinical Applicationsseries will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering as well as cancer or genetics research.

Genetic Approaches to Noncommunicable Diseases

Автор: Kare Berg; Victor Boulyjenkov
Название: Genetic Approaches to Noncommunicable Diseases
ISBN: 364264662X ISBN-13(EAN): 9783642646621
Издательство: Springer
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Цена: 15372.00 р.
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Описание: In recent years, the progress made in the prevention of mortality and morbidity caused by communicable diseases and malnutrition has changed the disease spectrum in both developed and, particularly developing countries.

Genetic Models of Immune and Inflammatory Diseases

Автор: Abul K. Abbas; Richard A. Flavell
Название: Genetic Models of Immune and Inflammatory Diseases
ISBN: 1461275202 ISBN-13(EAN): 9781461275206
Издательство: Springer
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Цена: 16769.00 р.
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Описание: Immunomodulatory agents have been expressed in defined tissues or throughout the body, providing tools for studying the functional consequences of dysregulated expression of biologi cal response modifiers.

Virus Host Cell Genetic Material Transport: Computational Ode/Pde Modeling with R

Автор: Schiesser William E.
Название: Virus Host Cell Genetic Material Transport: Computational Ode/Pde Modeling with R
ISBN: 303068864X ISBN-13(EAN): 9783030688646
Издательство: Springer
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Цена: 18167.00 р.
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Описание: The reproduction and spread of a virus during an epidemic proceeds when the virus attaches to a host cell and viral genetic material (VGM) (protein, DNA, RNA) enters the cell, then replicates, and perhaps mutates, in the cell. The movement of the VGM across the host cell outer membrane and within the host cell is a spatiotemporal dynamic process that is modeled in this book as a system of ordinary and partial di?erential equations (ODE/PDEs). The movement of the virus proteins through the cell membrane is modeled as a diffusion process expressed by the di?usion PDE (Fick’s second law). Within the cell, the time variation of the VGM is modeled as ODEs. The evolution of the dependent variables is computed by the numerical integration of the ODE/PDEs starting from zero initial conditions (ICs). The departure of the dependent variables from zero is in response to the virus protein concentration at the outer membrane surface (the point at which the virus binds to the host cell). The numerical integration of the ODE/PDEs is performed with routines coded (programmed) in R, a quality, open-source scienti?c computing system that is readily available from the Internet. Formal mathematics is minimized, e.g., no theorems and proofs. Rather, the presentation is through detailed examples that the reader/researcher/analyst can execute on modest computers. The ODE/PDE dependent variables are displayed graphically with basic R plotting utilities. The R routines are available from a download link so that the example models can be executed without having to ?rst study numerical methods and computer coding. The routines can then be applied to variations and extensions of the ODE/PDE model, such as changes in the parameters and the form of the model equations.


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