Compendium of in vivo monitoring in real-time molecular neuroscience - volume 2: microdialysis and sensing of neural tissues, Potter, Patricia A. (director Of Research,patient Care Services,barnes-jewish Hospital,st. Louis, Missouri) Perry, Anne Griffin (professor Emerita,sch
Описание: This monograph reviews and synthesizes 182 recent GCO studies that have appeared since the last significant review published in 2013 through the end of 2019. The authors categorize studies into the three broad areas of GCO 1) determinants, 2) accuracy, and 3) consequences.
Volume 1 of this series focused mainly on small molecules which are intrinsically electroactive. Volume 2 continues to provide current approaches to real time measurements of essential species in the central nervous system. It describes microdialysis, a sampling technique, which facilitates the removal of small volumes of solution containing the analyte(s) of interest which can be subsequently separated by chromatography and analyzed by a range of techniques. These include electrochemistry, UV-Vis spectroscopy, fluorescence and mass spectroscopy. This approach affords the opportunity to measure a range of targets in real-time thus providing access to pharmacokinetic/pharmacodynamics measurements affording the possibility of measuring the disappearance of a drug after administration and the subsequent appearance of metabolites. Microdialysis further affords the ability to sample peptides and proteins of neurobiological interest.
Consistent with the goals of Volume 1, Volume 2 seeks to provide for scientists in the field of neurobiology a base of bioanalytical techniques that may not be familiar to them. Specific examples are provided and the fundamental basis of the technique is also covered.
This book is the third in a series entitled, Compendium of In-Vivo Monitoring in Real-time Molecular Neuroscience. Its purpose is to provide a cross-section of research addressing monitoring in the rodent, and in some cases, the human brain.
Detailed understanding of the neurobiology of the brain is demanding and involves increasingly wider scope of talent ranging from physicists, neurobiologists, chemists, molecular biologists and bioengineers. Coming from varied backgrounds, they do not necessarily understand how to formulate functional issues in a mutually understandable way. This aim of this book is to provide information which can serve as a starting point for understanding such a complex topic.
The authors provide "tutorial" writing for specialists, as well as material understandable to a wide audience including neuroscientists, those interested in drug discovery, and those using such measurements for diagnosis purposes.
Описание: This new volume documents the transition from the development of electrochemical monitoring of brain function, now more than 40 years old, to fundamental neuroscience.
Описание: Analyzes trends in noninvasive optical glucose sensing and discusses its impact on tissue optical properties. This book presents methods that improve the accuracy in glucose prediction based on infrared absorption spectroscopy. It examines skin glucose monitoring by near-infrared spectroscopy, and fluorescence-based glucose biosensors.
Описание: This book examines the diverse facets of popular music in Malta, paying special attention to ghana (Malta`s folk song), the wind band tradition, and modern popular music.
Описание: This book explores and assesses the multiple levels at which linguistic policies can be challenged, devised and enacted, i.e. sub-national, national and supranational, and the variety of state and non-state actors involved.
Автор: Stanta Название: Guidelines for molecular analysis in archive tissues ISBN: 3642178898 ISBN-13(EAN): 9783642178894 Издательство: Springer Рейтинг: Цена: 13969.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A huge amount of fixed and paraffin-embedded tissue is stored in every hospital. This is very precious material that can be used for translational research and for diagnostics. The molecular methods employed for analysis of these tissues are similar to the usual molecular biology and proteomics methods, but reliable results can be obtained only if specific steps are followed with great care. This book provides detailed and precise guidelines for molecular analysis of archive tissues and will serve as an invaluable aid for researchers and pathologists involved in translational research and diagnostics. Clear notes and explanations are included to simplify use of the protocols for the less experienced. The authors are a group of acknowledged experts who have developed the described methods and validated them within the European project Archive Tissues: Improving Molecular Medicine Research and Clinical Practice - IMPACTS , which has involved 21 leading institutions in 11 countries.
Автор: Helmut Acker Название: Oxygen Sensing in Tissues ISBN: 3642834469 ISBN-13(EAN): 9783642834462 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Giuseppe Di Giovanni; Vincenzo Di Matteo Название: Microdialysis Techniques in Neuroscience ISBN: 1493958143 ISBN-13(EAN): 9781493958146 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book covers practical aspects of microdialysis in animals and humans, highlighting current technical limitations and offering a vision of what`s to come in the determination of the most disparate compounds in the brain. Offers practical tips and more.
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