Описание: Despite the large U.S. investment in health science, and the vast and growing body of peer-reviewed research findings it has produced, a compelling body of evidence suggests that research too often has been slow, inefficient, and fallen short of desired impacts on health.
Автор: Mittal Sandeep Название: Targeting the Broadly Pathogenic Kynurenine Pathway ISBN: 3319363212 ISBN-13(EAN): 9783319363219 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Tryptophan metabolism via kynurenine pathway plays a critical role in both health and a variety of human diseases. This book highlights the known associations between kynurenine pathway and various disease states, as well as examines the current status of drug development and clinical trials of compounds known to alter tryptophan metabolism. The research plays a critical role in molecular targeted therapies directed at altering the kynurenine pathway of tryptophan metabolism. The initial and rate-limiting step of tryptophan metabolism is mediated by one of two enzymes, tryptophan-2,3-dioxygenase (TDO; predominantly in the liver, but also in the brain) and indoleamine-2,3-dioxygenase (IDO; in a host of tissues in response to immune activation). Targeting the enzymes IDO and TDO, as well as other downstream effectors would therefore be likely to generate novel treatment options that would be helpful in a wide variety of clinical settings. This book provides a unique bridge between basic mechanistic understanding of the role of the kynurenine pathway with translational applications and clinical relevance. It will explore the indications that tryptophan metabolism is a potential biomarker of disease activity, can contribute to local and possibly systemic immune suppression in cancer, and is an attractive target for which a variety of inhibitors are readily available.
Описание: This thesis presents an experimental study of quantum memory based on cold atomic ensembles and discusses photonic entanglement. It mainly focuses on experimental research on storing orbital angular momentum, and introduces readers to methods for storing a single photon carried by an image or an entanglement of spatial modes. The thesis also discusses the storage of photonic entanglement using the Raman scheme as a step toward implementing high-bandwidth quantum memory. The storage of photonic entanglement is central to achieving long-distance quantum communication based on quantum repeaters and scalable linear optical quantum computation. Addressing this key issue, the findings presented in the thesis are very promising with regard to future high-speed and high-capacity quantum communications.
Автор: A. Broadbent Название: Philosophy of Epidemiology ISBN: 1349346853 ISBN-13(EAN): 9781349346851 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Epidemiology is one of the fastest growing and increasingly important sciences. This thorough analysis lays out the conceptual foundations of epidemiology, identifying traps and setting out the benefits of properly understanding this fascinating and important discipline, as well as providing the means to do so.
Автор: Ferenc Toth Название: Cost-Benefit Analyses of Climate Change ISBN: 3034898312 ISBN-13(EAN): 9783034898317 Издательство: Springer Рейтинг: Цена: 11753.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The Potsdam Institute for Climate Impact Research (PIK) was founded in 1992 as a "Blue List" research institute, with the Federal Ministry for Education, Science, Research and Technology and the Ministry for Science, Research and Culture of the federal state of Brandenburg each provid- ing half ofthe funding.
Автор: Stephen C. Aronoff Название: Translational research and clinical practice ISBN: 0199746443 ISBN-13(EAN): 9780199746446 Издательство: Oxford Academ Рейтинг: Цена: 6493.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Translational Research and Clinical Practice offers a clear and comprehensive introduction to evidence-based medicine. It provides a unified framework on how to find, validate, critically analyze, and apply the clinical literature to patient care.
Автор: Wu A. Название: Pharmacogenomic testing in current clinical practice ISBN: 1607612828 ISBN-13(EAN): 9781607612827 Издательство: Springer Рейтинг: Цена: 30606.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: While the basic principles of personalized medicine and pharmacogenomics has been covered by numerous texts, there are none to date that focuses on the specific tests themselves that are in current clinical practice and those that are being proposed for implementation in the near future. Pharmacogenomic Testing in Current Clinical Practice: Implementation in the Clinical Laboratory focuses almost entirely on the specifics of each test that is needed to implement these tests into a clinical laboratory. This volume presents the first compilation of the tests currently in routine clinical use. The chapter authors of this unique and invaluable title comprise a range of renowned authorities and investigators who have conducted the essential clinical trials necessary to justify pharmacogenomic testing today. The book is divided into four parts: Basic Concepts, Specific Pharmacogenomic Targets, Drugs that Cause Delayed Hypersensitivity, and Miscellaneous Drugs. Each author provides a pharmacologic background on the target drug, the need for pharmacogenomic testing, and how results can be translated into clinical decisions. Where appropriate, case studies are given to illustrate typical clinical scenarios. An extensive bibliography is provided so that the reader can refer to the original studies. This well-designed resource will appeal to clinical laboratory directors who are contemplating or assigned the task of establishing a pharmacogenomics laboratory and a wide range of clinicians who must interpret results of testing. Focused and immensely useful, Pharmacogenomic Testing in Current Clinical Practice: Implementation in the Clinical Laboratory is a timely and outstanding contribution to the literature and will be instrumental in defining this rapidly growing field.
Автор: Vassilios Vassiliou; Edward Chow; Dimitrios Kardam Название: Bone Metastases ISBN: 9402405003 ISBN-13(EAN): 9789402405002 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Preface. I FUNDAMENTAL CONCEPTS.1 Pathophysiology of metastatic bone disease. 2 Bone metastases: epidemiology, clinical picture, SREs and prognosis. 3 Pain in bone metastases: types and mechanisms. II INVESTIGATIONS OF BONE METASTASES. 4 Radiological evaluations: radiography, CT, MRI. 5 Nuclear medicine imaging modalities: bone scintigraphy, PET-CT, SPECT. 6. Bone turnover markers. 7. New omics approaches for bone metastases. III THERAPEUTIC MANAGEMENT. 8 Analgesic treatment for bone mets. 9. Radiotherapy: external beam and radio-surgery. 10 Radionuclide therapy.11. Bisphosphonates. 12 New targeted therapies for bone metastases. 13. Chemotherapy and hormone therapy. 14 HIFU/Radioablation. 15 Neuropathic bone metastases. 16. Spinal cord compression and cauda equina compression. 17 Pathological and impending fracture. 18 Re-irradiation. 19. Bone metastases in elderly patients. 20. Management of metastatic bone disease in the elderly with bisphosphonates and RANKL inhibitors: effectiveness and safety. IV ASSESMENT OF THERAPEUTIC RESPONSE. 21 Radiological and nuclear medicine imaging modalities. 22 Clinical assessment measures. 23 Outcome measures in bone metastases clinical trials. 24 Quality of life in patients suffering from metastatic skeletal disease. V COST OF MANAGING METASTATIC BONE DISEASE. 25 Cost effectiveness of treatment modalities for bone metastases. Index.
Автор: Vassiliou Название: Bone Metastases ISBN: 9400775687 ISBN-13(EAN): 9789400775688 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Robertson, David Название: Clinical and Translational Science ISBN: 0128021012 ISBN-13(EAN): 9780128021019 Издательство: Elsevier Science Рейтинг: Цена: 22233.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science.
Автор: Shashi Bala Singh; Nanduri R. Prabhakar; Srinivas Название: Translational Research in Environmental and Occupational Stress ISBN: 8132235223 ISBN-13(EAN): 9788132235224 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With the ever increasing interest in this branch and the dreams and aspirations that this field can bring, basic science researchers are now taking a bold step into this new realm, merging different fields of knowledge to come up with novel inventions.
Автор: Turksen Название: Cell Biology and Translational Medicine, Volume 16 ISBN: 3031106377 ISBN-13(EAN): 9783031106378 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the 16th volume of a continuing series. Chapter "Epithelial Stem Cells: Making, Shaping and Breaking the Niche" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
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