Gullberg Integrins in Health and Disease 9783031237805

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Автор: Gullberg
Название: Integrins in Health and Disease
ISBN: 9783031237805
Издательство: Springer
Классификация:

Белки

Клеточная биология (цитология)

ISBN-10: 3031237803
Обложка/Формат: Hardback
Страницы: 472
Вес: 0.89 кг.
Дата издания: 11.03.2023
Серия: Biology of Extracellular Matrix
Язык: English
Издание: 1st ed. 2023
Иллюстрации: 1 illustrations, black and white; xii, 472 p. 1 illus.
Размер: 235 x 155
Читательская аудитория: Professional & vocational
Основная тема: Life Sciences
Подзаголовок: Key effectors of cell-matrix and cell-cell interactions
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Integrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide range of physiological processes including tissue morphogenesis, wound healing, and regulation of cell growth, but also in numerous pathological conditions such as autoimmunity, infectious disease, and carcinogenesis. This book aims to provide readers a summary of the most important integrins and their respective biological functions. Readers will learn about knockout- and animal models to study the functionality of key collagen-, laminin-, and nephronectin-binding integrins. Additionally, the role of integrins in pathological tissue remodeling in joints and in developing and diseased cardiac tissue are discussed. Reviews of the current knowledge of the role of integrins in tissue and tumor fibrosis, angiogenesis and tumor progression are an important part of this work. Finally, the book discusses integrins in the context of the immune system, how to target integrin-ligand interactions with antibodies, and the role of integrins as receptors for bacterial and viral cell invasion. Both experienced researchers and clinicians, as well as PhD students who wish to study the extracellular matrix and cell adhesion molecules will find “Integrins in Health and Disease - Key Effectors of Cell-Matrix and Cell-Cell Interactions” authoritative, easily accessible, and vastly informative. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
Дополнительное описание: Part 1: Knockouts and animal models.- Integrins ?1?1 and ?2?1 – The generalist collagen receptors.- Roles for Integrin ?3?1 in Development and Disease.- Part 2: Fibrosis& Cancer.- Integrins: Key targets in tissue fibrosis and tumor stroma.- Integrins in C

Integrins in Health and Disease, Gullberg