Описание: A world in turmoil ... The year is 2020 and mankind is in the throes of a global pandemic. 15 million people are infected with COVID-19, the respiratory and immunological disease caused by a novel coronavirus that originated in Wuhan, China. While doctors flounder and economies crash, officials point to bats as the source of the virus. There's just one problem. The bats were hibernating. Explore the facts ... This book investigates the origins of the novel coronavirus, SARS-CoV-2. Written in a candid style that encourages you to think for yourself, you'll engage with shifting narratives that explore the possible source of the virus--from the official story touted by the mainstream media to the bombshell reports commonly dismissed as conspiracy theories, and decide for yourself which of those is worth a second look Discover the truth ... Read Coronavirus Origins to learn: - The glaring flaws in the widely accepted bat theory - Why the strange structure of SARS-CoV-2 has some scientists speaking out about a possible lab origin - Go inside China's deadliest super-lab--right across the street from the pandemic's epicenter - How China's biowarfare program dovetails with a history of human rights violations - The tragic stories of the brave whistleblowers silenced for speaking out about the killer virus - Where the U.S. Army sent their top athletes a month before the outbreak--in a move that reeks of foul play - The names of suspected spies who shipped viral samples to China - The identity of a missing woman many believe to be Patient 0--a lab worker who disappeared after being trained by the world's top bat virologist. Her online presence, purposefully erased Deep dive into the stories government and media don't want you to know and come to your own conclusions about the origins of coronavirus
Описание: Why the Spike protein is relevant for COVID19 therapeutics
Whole genome mutation rates
Phylogenetic systems
Mechanism of immune escape: single nucleotide mutations, insertion/deletions, and recombination. Spike protein mutations detected in currently circulating strains.
SARS-CoV-2 variants
B.1.1.298
B.1.1.7 (alpha)
B.1.351 (beta)
B.1.1.28- and B.1.1.33-derived Brazilian variants (including gamma and zeta)
B.1.525 (eta)
B.1.526 (iota)
B.1.427/B.1.429 (epsilon)
B.1.617-derived variants (including kappa and delta)
B.1.617.1
Delta VOC
C.37 (lambda)
P.3 (theta)
Other variants under monitoring (VUM)
Which strain will finally become dominant?
SARS-CoV-2 variants characterization
Predicting the functional consequences of mutations
Efficacy of vaccines and monoclonal antibodies against SARS-CoV-2 variants
Selective pressures exerted by antibody-based therapeutics
Описание: This book presents a complete overview of COVID-19 and provides a series of in-depth analyses of the literature and a comprehensive discussion and perspectives on promising anti-SARS-CoV-2 agents based on the system of ethnopharmacology, which covers Chinese medicine, traditional medicines of India and Africa, Turkish folk medicine, essential oils, and some well-known medicinal plants. In this book, the current status of therapeutic strategies against COVID-19 was summarized and a perspective of potential options for the future was proposed. Based on ethnopharmacology, some well-established traditional herbal formulations and bioactive compounds with anti-virus activity were repurposed for managing COVID-19 and post-illness, including neurological disorders and kidney illness. Using drug discovery tools, promising immune enhancers were explored from phytochemicals against SARS-CoV-2. Nutraceuticals from dietary plants, spices, and fruits with anti-virus and antioxidant activities were recommended to prevent infection or severe illness caused by emerging variants. With the aid of systems pharmacology, researchers have gained insights into possible molecular mechanisms of anti-SARS-CoV-2 activity and have predicted a range of candidate compounds from medicinal plants to combat COVID-19. This book explores the current knowledge of drug discovery and ethnopharmacology for managing coronavirus diseases. The content proved the anti-SARS-CoV-2 activity from natural products and traditional herbal medicines. It contributes to the management of global public health and fits the goal of establishing “Good Health and Well-Being,” which is one of “The Sustainable Development Goals (SDGs) 2030".
Автор: Egbuna, Chukwuebuka Название: Coronavirus Drug Discovery ISBN: 0323851568 ISBN-13(EAN): 9780323851565 Издательство: Elsevier Science Рейтинг: Цена: 29476.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Rory Noland`s classic The Heart of the Artist explores character issues facing Christian artists including servanthood versus stardom, handling criticism, jealousy and envy, managing your emotions, and more. Now in an updated second edition it is the ideal resource for artists who want to use their gifts more effectively in church ministry.
Автор: Bazin Название: Revival: Rat Hybridomas and Rat Monoclonal Antibodies (1990) ISBN: 1138561649 ISBN-13(EAN): 9781138561649 Издательство: Taylor&Francis Рейтинг: Цена: 11482.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The purpose of this book is to provide information which supports the fact that rat hybridomas are no more difficult to develop than mouse hybridomas. This is the first book devoted to the development of rat hybridomas. It includes theories, step-by-step techniques, ingredients and apparatus.
Автор: Bazin Название: Rat Hybridomas and Rat Monoclonal Antibodies (1990) ISBN: 1138506109 ISBN-13(EAN): 9781138506107 Издательство: Taylor&Francis Рейтинг: Цена: 41342.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The purpose of this book is to provide information which supports the fact that rat hybridomas are no more difficult to develop than mouse hybridomas.
Автор: Greenfield Edward A. Название: Antibodies a Laboratory Manual, Second Edition ISBN: 1936113813 ISBN-13(EAN): 9781936113811 Издательство: Неизвестно Рейтинг: Цена: 24140.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: It has been 25 years since the now-classic Antibodies by Ed Harlow and David Lane appeared. While some things remain the same, many have changed. This second edition of Antibodies, edited by Edward A. Greenfield of the Dana-Farber Cancer Institute builds on the core strengths of the first edition, presenting clear and authoritative protocols with extensive background information and troubleshooting advice. The original introductory chapters have been recast and updated to take into account our current understanding of the immune system. The critical chapters on generating monoclonal antibodies and growing hybridomas, which demystified hybridoma generation, have been greatly expanded and updated to make these procedures easy to follow and adaptable to current research needs. The remaining chapters contain all new protocols and topics and reflect the progress in how antibodies are studied and used since the appearance of the original edition. These include: � antibody purification and storage � engineering antibodies, including use of degenerate oligonucleotides, 5'-RACE, phage display, and mutagenesis � extensive labeling techniques � new immunoblotting protocols � the latest screening and labeling techniques As Dr. Greenfield notes in his preface to this second edition: "The Antibodies manual provided our laboratory with guidance in the form of protocols and recommendations for setting up a hybridoma facility. Everything we needed to know to make a monoclonal antibody was all there, neatly packaged in an easy-to-understand book...the second edition is intended to provide the necessary information and protocols to assist investigators with their first monoclonal antibody effort as well as to provide guidance for more experiences antibody makers who are having some difficulties with a particular project." I have the first edition. Why should I buy the second edition? While the core of the first edition appears in updated and recast form in the second edition, more than half of the second edition contains entirely new information and protocols to reflect the changes in the field since the first edition. To whom is this edition addressed? Is this a book for immunologists? As with the first edition, the second edition provides information and protocols for both the neophyte and the experienced investigator. It dissects the mysteries of producing the antibodies and reagents you need for your experiments with the needs of molecular biologists in mind. It is the perfect book for new members of your lab as it has sufficient background information to provide context as well as clear, step-by-step instructions for performing the needed experiments-both the why and the how for these techniques. And if things go wrong, there is extensive troubleshooting to diagnose the problem. Are the protocols in this book better than those available for download on the Web? Many of the protocols available on the Web are perfectly good, but there are many that are not. Reagents are expensive and deadlines are tight. CSHL Press manuals provide protocols that have been formulated and tested in the labs of leading investigators in the field. They are reliable and they work. And they include the context and troubleshooting information that many online protocols do not have.
Автор: David M. Goldenberg Название: Cancer Imaging with Radiolabeled Antibodies ISBN: 1461288053 ISBN-13(EAN): 9781461288053 Издательство: Springer Рейтинг: Цена: 51570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelf or by a single personal subscription.
Автор: Matzku Название: Antibodies in Diagnosis and Therapy ISBN: 9057023105 ISBN-13(EAN): 9789057023101 Издательство: Taylor&Francis Рейтинг: Цена: 33686.00 р. Наличие на складе: Нет в наличии.
Автор: Richard P. Baum; P.H. Cox; Gustav H?r; Gian Luigi Название: Clinical Use of Antibodies ISBN: 9401055556 ISBN-13(EAN): 9789401055550 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: It was at Frankfurt/Mainin 1899 that Paul Ehrlich first expounded his famous "site-chain theory" -which described the basic immunological principal of antibody-antigen interactio- on the occasion of the opening of the Institute for Experimental Therapeutics (which was later named after him).
Автор: David M. Goldenberg Название: Cancer Imaging with Radiolabeled Antibodies ISBN: 0792306317 ISBN-13(EAN): 9780792306313 Издательство: Springer Рейтинг: Цена: 51570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelf or by a single personal subscription.
Описание: This book serves to expand the research around the illness in order to enable health care researchers and practitioners to address the questions that are imperative to individuals suffering from this condition. It puts forth a maturation of research and interventions that are theoretically sound and creative in the Long COVID area.
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