The Human Complement System in Health and Disease, Volanakis, John E.

Автор: Janos Szebeni
Название: The Complement System
ISBN: 1475779283 ISBN-13(EAN): 9781475779288
Издательство: Springer
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Описание: As a phylogenetically old system complement is now regarded as a part of innate immunity.

Автор: K. Whaley; M. Loos; J. Weiler
Название: Complement in Health and Disease
ISBN: 9401049815 ISBN-13(EAN): 9789401049818
Издательство: Springer
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Описание: These advances are now facilitating research into the structure of the complement proteins, the nature of the complement deficiency syndromes, the regulation of complement gene expression and the role of complement in different diseases.

Автор: Mihaela Gadjeva
Название: The Complement System
ISBN: 1493963066 ISBN-13(EAN): 9781493963065
Издательство: Springer
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Описание: This book presents a variety of protocols used to purify and analyze the activity of the individual complement components or pathways. It features step-by-step, readily reproducible laboratory protocols and expert implementation advice.

Название: Structural Biology of the Complement System
ISBN: 0367454173 ISBN-13(EAN): 9780367454173
Издательство: Taylor&Francis
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Описание: The only in-depth guide on the subject, this is the first resource to present the structural biology of the complement system in connection to immunology and drug development. Integrating the latest breakthroughs in structural biology and immunology, this book includes detailed discussions of the structure-function relationships among complement sy

Автор: Mihaela Gadjeva
Название: The Complement System
ISBN: 1627037233 ISBN-13(EAN): 9781627037235
Издательство: Springer
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Описание: This book presents a variety of protocols used to purify and analyze the activity of the individual complement components or pathways. It features step-by-step, readily reproducible laboratory protocols and expert implementation advice.

Автор: K. Rother; Gerd O. Till; Gertrud M. H?nsch
Название: The Complement System
ISBN: 3642637116 ISBN-13(EAN): 9783642637117
Издательство: Springer
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Описание: The aim of the former editions remains unchanged in the present updated version, namely to put forward a general and comprehensive review on complement. The editors are grateful that the invited authors, all of them leading scientists in their field, helped again to make The Complement System a true mirror of the state of the art.

Автор: John D. Lambris; V. Michael Holers
Название: Therapeutic Interventions in the Complement System
ISBN: 1468496123 ISBN-13(EAN): 9781468496123
Издательство: Springer
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Описание: A team of expert investigators and clinical researchers comprehensively review complement`s basic biology, its role in disease, methods to measure its activity, and strategies for its inhibition in patients.

Автор: Stoute
Название: Complement Activation in Malaria Immunity and Pathogenesis
ISBN: 3319772570 ISBN-13(EAN): 9783319772578
Издательство: Springer
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Описание: Plasmodium falciparum malaria is responsible for the deaths of nearly 500,000 people each year. Much attention has been paid to antibody and cellular mechanisms of immunity against this pathogen. By contrast, the role that the complement system plays in immunity and pathogenesis in this infection is not very well recognized or understood. Based on the work of a number of research groups, we know that complement plays an important role in these processes. In this book, some of the leading scientists in the field discuss the mechanisms of complement activation during malaria infection as well as the role of complement in the pathogenesis of key syndromes such as severe malarial anemia, cerebral malaria, and placental malaria. In addition, they review recently-identified complement evasion strategies of P. falciparum merozoites, and how these mechanisms may translate into paradoxical enhancement of infection rather than protection. Finally, they also discuss the role of the mosquito complement system on immunity against the parasite.

Автор: B. Paul Morgan
Название: Complement Methods and Protocols
ISBN: 1617371165 ISBN-13(EAN): 9781617371165
Издательство: Springer
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Описание: The complement system, first described more than a century ago, was for many years the ugly duckling of the immunology world, but no more.

Автор: John D. Lambris
Название: Current Topics in Complement
ISBN: 1461498015 ISBN-13(EAN): 9781461498018
Издательство: Springer
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Описание: Complement has long been regarded as a pivotal effector arm of the innate im-mune response, eliciting important immunoregulatory functions in the context of inflammation and also serving as a vital link between the innate and adaptive immune response. In the post-genomic era, our knowledge of the innate immune system is enriched by findings that point to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or inflammation. Several studies indicate that complement proteins exert functions that are either more complex than previously thought, or go well beyond the innate immune character of the system. The advent of high-throughput platforms for genome and proteome-wide profiling, together with the enormous amount of raw genetic information that has accumulated in the databases, have stirred new expectations in biomedical research. They have led complementologists to revisit established biological systems, such as the complement system, from a global and integrative perspec-tive. Complement research is now faced with the challenge of trying to integrate isolated biochemical pathways into complex gene and protein regulatory cir-cuits. In this respect, scientists from around the world convened at the Third Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 5–10, 2005), to discuss recent advances in this fast evolving field. This volume represents a collection of topics on the "novel" functions of complement, pathophysiology, protein structures, design of complement inhibitors, and complement assays discussed during the conference.

Автор: H.J. M?ller-Eberhard; P.A. Miescher
Название: Complement
ISBN: 3540150757 ISBN-13(EAN): 9783540150756
Издательство: Springer
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Автор: John D. Lambris
Название: The Third Component of Complement
ISBN: 3642749798 ISBN-13(EAN): 9783642749797
Издательство: Springer
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Описание: The third component of complement, C3, is one of the most versatile proteins and an important participant in immune surveillance and immune response pathways. VOLANAKIS: Participation of C3 and Its Ligands in Complement Activation . TACK: Biosynthesis and Genetics of C3 .