Non-clinical Statistics in Drug Discovery, Crimin, Kimberly
Автор: Zammitt Nicola Название: Essentials of Kumar and Clark`s Clinical Medicine,7 ed. IE ISBN: 0702082805 ISBN-13(EAN): 9780702082801 Издательство: Elsevier Science Рейтинг: Цена: 3683.00 р. Наличие на складе: Есть (1 шт.) Описание: AVAILABLE TO PREORDER NOWFrom the bestselling and Booker Prize winning author of Never Let me Go and The Remains of the Day, a stunning new novel - his first since winning the Nobel Prize in Literature - that asks, what does it mean to love? A thrilling feat of world-building, a novel of exquisite tenderness and impeccable restraint, Klara and the Sun is a magnificent achievement, and an international literary event.
Автор: Bonnel Wanda, Smith Katharine Название: Proposal Writing for Clinical Nursing and DNP Projects ISBN: 082614442X ISBN-13(EAN): 9780826144423 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 5267.00 р. 7524.00-30% Наличие на складе: Есть (1 шт.) Описание: Through her illuminating and detailed analyses of both the Reagan presidency and many blockbuster movies, Susan Jeffords provides a scenario within which the successes of the New Right and the Reagan presidency can begin to be understood: she both encourages an understanding of how this complicity functioned and provides a framework within which to respond to the New Right`s methods and arguments.
Автор: Gill, Denis O`Brien, Niall Название: Paediatric Clinical Examination Made Easy 6E IE (Pediatric) ISBN: 0702072893 ISBN-13(EAN): 9780702072895 Издательство: Elsevier Science Рейтинг: Цена: 2799.00 р. Наличие на складе: Есть (1 шт.) Описание: "For over a century and in scores of countries, patriarchal presumptions and practices have been challenged by women and their male allies. "Sexual harassment" has entered common parlance; police departments are equipped with rape kits; more than half of the national legislators in Bolivia and Rwanda are women; and a woman candidate won the plurality of the popular votes in the 2016 United States presidential election. But have we really reached equality and overthrown a patriarchal point of view? The Big Push exposes how patriarchal ideas and relationships continue to be modernized to this day. Through contemporary cases and reports, renowned political scientist Cynthia Enloe exposes the workings of everyday patriarchy--in how Syrian women civil society activists have been excluded from international peace negotiations; how sexual harassment became institutionally accepted within major news organizations; or in how the UN Secretary General`s post has remained a masculine domain. Enloe then lays out strategies and skills for challenging patriarchal attitudes and operations. Encouraging self-reflection, she guides us in the discomforting curiosity of reviewing our own personal complicity in sustaining patriarchy in order to withdraw our own support for it. Timely and globally conscious, The Big Push is a call for feminist self-reflection and strategic action with a belief that exposure complements resistance."--Provided by publisher.
Автор: Sadao Nagaoka Название: Drug Discovery in Japan ISBN: 9811389055 ISBN-13(EAN): 9789811389054 Издательство: Springer Рейтинг: Цена: 11179.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book analyzes the drug-discovery process in Japan, based on detailed case studies of 12 groups of 15 innovative drugs. It covers the first statin in the world up to the recent major breakthrough in cancer therapy, the recent immune checkpoint inhibitor, the scientific discovery for which a 2018 Nobel Prize in Physiology or Medicine was awarded to Prof. Tasuku Honjo, Kyoto University. The book shows the pervasive high uncertainty in drug discovery: frequent occurrences of unexpected difficulties, discontinuations, serendipities, and good luck, significantly because drug discovery starts when the underlying science is incomplete. Thus, there exist dynamic interactions between scientific progress and drug discovery. High uncertainty also makes the value of an entrepreneurial scientist high. Such scientists fill the knowledge gaps by absorbing external scientific progress and by relentless pursuit of possibilities through their own research, often including unauthorized research, to overcome crises. Further, high uncertainty and its resolution significantly characterize the evolution of competition in the drug industry. The patent system promotes innovation under high uncertainty not only by enhancing appropriability of R&D investment but also by facilitating the combination of knowledge and capabilities among different firms through disclosure. Understanding such a process significantly benefits the creation of innovation management and policy practices.
Описание: The classification of pituitary disease is becoming easier, and as targeted therapies are being developed, the role of the pathologist in determining accurate diagnoses is increasingly important. The surgical pathologist must therefore recognise the important role of morphologic analysis in classifying sellar pathology for the diagnosis and management of the pituitary patient. Highly illustrated.
Автор: Ali Mousavi Название: Persepolis: Discovery and Afterlife of a World Wonder ISBN: 1614510288 ISBN-13(EAN): 9781614510284 Издательство: Walter de Gruyter Рейтинг: Цена: 24165.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Persepolis: Discovery and Afterlife of a World Wonder presents the first full study of the history of archaeological exploration at Persepolis after its destruction in 330 BC.
Автор: Louise Ryan,Umut Erel,Alessio D`Angelo Название: Migrant Capital: Networks, Identities and Strategies ISBN: 1137348798 ISBN-13(EAN): 9781137348791 Издательство: Springer Рейтинг: Цена: 11179.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Migrant Capital presents state-of-the-art empirical, theoretical and methodological perspectives on migration, networks, social and cultural capital, exploring the ways in which these bodies of literature can inform and strengthen each other. In so doing,
Автор: Shay Soker; Aleksander Skardal Название: Tumor Organoids ISBN: 3319605097 ISBN-13(EAN): 9783319605098 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.
Описание: Kalman J. Kaplan and Paul Cantz offer a biblically-based approach to suicide prevention, designed to overcome suicidogenic patterns in fourteen patients fitting into seven Graeco-Roman suicidal syndromes. Kaplan and Cantz use biblical narratives alongside an in-depth positive psychology, aimed at promoting life instead of simply preventing suicide.
Описание: The book shows the pervasive high uncertainty in drug discovery: frequent occurrences of unexpected difficulties, discontinuations, serendipities, and good luck, significantly because drug discovery starts when the underlying science is incomplete.
Автор: Butterworth John F., Mackey David C., Wasnick John Название: Morgan and Mikhail`s Clinical Anesthesiology, 6th Edition ISBN: 1259834425 ISBN-13(EAN): 9781259834424 Издательство: McGraw-Hill Рейтинг: Цена: 12353.00 р. Наличие на складе: Поставка под заказ.
Описание: Increased urbanization coupled with demand for water has placed the provision of a sustainable supply of clean water high on the agenda for large cities. The approach of this book is to describe and compare various contexts in a range of global cities, reviewing different approaches and perspectives that examine key urban water governance issues.
Автор: Major, R.H. Название: India in the Fifteenth Century ISBN: 1409412881 ISBN-13(EAN): 9781409412885 Издательство: Taylor&Francis Рейтинг: Цена: 20671.00 р. Наличие на складе: Поставка под заказ.
Описание: The volume contains the following accounts, edited, with an introduction: Narrative of the voyage of Abd-er-Razzak, Ambassador from Shah Rukh, A.H. 845, A.D. 1442.; The travels of Nicolo Conti in the East in the early part of the fifteenth century; The travels of Athanasius Nikitin, a native of Twer; The journey of Hieronimo di Santo Stefano, a Genoese.
This is a new print-on-demand hardback edition of the volume first published in 1857.
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