Innovative Clinical Trial Designs for Evidence-Based Medicine, Lai, Tze Leung
Автор: Thomas B. Newman, Michael A. Kohn Название: Evidence-Based Diagnosis : An Introduction to Clinical Epidemiology ISBN: 1108436714 ISBN-13(EAN): 9781108436717 Издательство: Cambridge Academ Рейтинг: Цена: 6970.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A rigorous yet engaging guide to understanding and choosing a range of diagnostic and prognostic tests. Topics explored include the diagnostic process, the reliability and accuracy of different tests and quantifying treatment benefits using randomized trails. Numerous worked examples and problems based on real situations support readers` learning.
Автор: Jenicek, Milos Название: Foundations of Evidence-Based Medicine ISBN: 1032088893 ISBN-13(EAN): 9781032088891 Издательство: Taylor&Francis Рейтинг: Цена: 11176.00 р. Наличие на складе: Поставка под заказ.
Автор: Kulkarni Kunal Название: Oxford Handbook of Key Clinical Evidence ISBN: 0198729421 ISBN-13(EAN): 9780198729426 Издательство: Oxford Academ Рейтинг: Цена: 5384.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This handbook digests and presents the key trials influencing current clinical practice, selected and summarised by figureheads in the medical and surgical specialties. The handbook format allows readers to quickly access and assimilate the evidence behind the practices and interventions experienced every day.
Автор: Jenicek, Milos (professor Emeritus At The Universite De Montreal And Former Adjunct Professor At Mcgill University, Ontario, Canada) Название: Foundations of evidence-based medicine ISBN: 0367187639 ISBN-13(EAN): 9780367187637 Издательство: Taylor&Francis Рейтинг: Цена: 26796.00 р. Наличие на складе: Поставка под заказ.
Описание: This comprehensive text focuses on reasoning, critical thinking and pragmatic decision making in medicine. Based on the author`s extensive experience, this fully-revised second edition provides invaluable guidance to the crucial role that clinical epidemiology plays in the expanding field of evidence-based medicine.
Автор: Jenkins, Marjorie Название: How Sex And Gender Impact Clinical Practice ISBN: 0128165693 ISBN-13(EAN): 9780128165690 Издательство: Elsevier Science Рейтинг: Цена: 19875.00 р. Наличие на складе: Поставка под заказ.
Описание:
How Sex and Gender Impact Clinical Practice: An Evidence-Based Guide to Patient Care enables primary care clinicians by providing a framework to understand differences and better care for patients in their practice. Each chapter covers a subspecialty in medicine and discusses the influence of sex hormones on disease, along with sex and gender-based differences in clinical presentation, physical examination, laboratory results, treatment regimens, comorbidities and prognosis. Illustrative case examples and practical practice points help each chapter come alive. A special chapter on communication differences between men and women assists clinicians in their conversations with patients.
This book fills an important need by applying years of research findings to sex and gender specific medical care and demonstrating that an individualized approach to patient care will lead to improved detection, treatment and prevention of disease.
Автор: Edited by Gillian Todd , Rhena Branch Название: Evidence-Based Treatment for Anxiety Disorders and Depression ISBN: 1108420893 ISBN-13(EAN): 9781108420891 Издательство: Cambridge Academ Рейтинг: Цена: 25027.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Written by internationally recognized experts, this CBT clinician`s manual provides disorder specific-chapters and accessible pedagogical features. The cutting-edge research, advanced theory, and advice on special adaptations make it an ideal reference for CBT practitioners, students, post-graduate CBT courses, and clinical psychology graduates.
Описание: Clinical trials require strategic thinking and innovative methods since some traditional methods are not adequate for the 21st century.To solve these problems requires good methodological skills, but also an in-depth knowledge of the practical problems we are dealing with and a strategic vision of the pig picture.
Автор: Chang, Mark (AMAG Pharmaceuticals, Inc, Lexington, Massachusetts, USA) Balser, John Roach, Jim Bliss, Robin Название: Innovative Strategies, Statistical Solutions and Simulations for Modern Clinical Trials ISBN: 1032093501 ISBN-13(EAN): 9781032093505 Издательство: Taylor&Francis Рейтинг: Цена: 7501.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Clinical trials require strategic thinking and innovative methods since some traditional methods are not adequate for the 21st century.To solve these problems requires good methodological skills, but also an in-depth knowledge of the practical problems we are dealing with and a strategic vision of the pig picture.
Описание: This comprehensive book features both new and established material on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data.
Автор: Yuan Название: Bayesian Designs for Phase I–II Clinical Trials ISBN: 1498709559 ISBN-13(EAN): 9781498709552 Издательство: Taylor&Francis Рейтинг: Цена: 16078.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is the first to focus on Bayesian phase I-II clinical trials. It describes many problems with the conventional phase I-phase II paradigm and covers a large number of modern Bayesian phase I-II clinical trial designs.
Описание: This book provides an up-to-date review of the general principles of and techniques for confirmatory adaptive designs. Confirmatory adaptive designs are a generalization of group sequential designs. With these designs, interim analyses are performed in order to stop the trial prematurely under control of the Type I error rate. In adaptive designs, it is also permissible to perform a data-driven change of relevant aspects of the study design at interim stages. This includes, for example, a sample-size reassessment, a treatment-arm selection or a selection of a pre-specified sub-population. Essentially, this adaptive methodology was introduced in the 1990s. Since then, it has become popular and the object of intense discussion and still represents a rapidly growing field of statistical research. This book describes adaptive design methodology at an elementary level, while also considering designing and planning issues as well as methods for analyzing an adaptively planned trial. This includes estimation methods and methods for the determination of an overall p-value. Part I of the book provides the group sequential methods that are necessary for understanding and applying the adaptive design methodology supplied in Parts II and III of the book. The book contains many examples that illustrate use of the methods for practical application. The book is primarily written for applied statisticians from academia and industry who are interested in confirmatory adaptive designs. It is assumed that readers are familiar with the basic principles of descriptive statistics, parameter estimation and statistical testing. This book will also be suitable for an advanced statistical course for applied statisticians or clinicians with a sound statistical background.
Автор: Atkinson, Anthony C , Biswas, Atanu Название: Randomised Response-Adaptive Designs in Clinical Trials ISBN: 0367378973 ISBN-13(EAN): 9780367378974 Издательство: Taylor&Francis Рейтинг: Цена: 9798.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Randomised Response-Adaptive Designs in Clinical Trials presents methods for the randomised allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training.
After introducing clinical trials in drug development, the authors assess a simple adaptive design for binary responses without covariates. They discuss randomisation and covariate balance in normally distributed responses and cover many important response-adaptive designs for binary responses. The book then develops response-adaptive designs for continuous and longitudinal responses, optimum designs with covariates, and response-adaptive designs with covariates. It also covers response-adaptive designs that are derived by optimising an objective function subject to constraints on the variance of estimated parametric functions. The concluding chapter explores future directions in the development of adaptive designs.
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