Описание: Advances that open new avenues in developing aminoglycoside antibiotics During the last twenty years, there have been numerous advances in the understanding of the chemistry, biochemistry, and recognition of aminoglycosides. This has led to the development of novel antibiotics and opened up new therapeutic targets for intervention.
Автор: Walsh Название: Antibiotics: Challenges, Mechanisms, Opportunities ISBN: 1555819303 ISBN-13(EAN): 9781555819309 Издательство: Wiley Рейтинг: Цена: 16466.00 р. Наличие на складе: Поставка под заказ.
Описание: Antibiotics: Challenges, Mechanisms, Opportunities details the contemporary challenges for discovery, optimization, and advancement of new antibiotics. It focuses on discovery not preclinical or clinical development. Given that the few classes of clinically significant antibiotics are all small molecules, this book focuses on the molecular structures and characteristics of both natural and synthetic antibacterial agents. Antibiotics is a valuable reference for microbiologists, bacterial physiologists, geneticists, pharmacologists, and drug developers. A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions: • What are antibiotics? • Where do antibiotics come from?• How do antibiotics work? • Why do antibiotics stop working? • How should our limited inventory of effective antibiotics be addressed? Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
Автор: Gallagher Jason C., Macdougall Conan Название: Antibiotics Simplified ISBN: 1284250067 ISBN-13(EAN): 9781284250060 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 6264.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book focuses on key points of basic microbiology and antimicrobial pharmacotherapy and organizes them into a concise guide … must-have antimicrobial reference guide for all medical and pharmacy students. - Lindsay McDonnell, PharmD for Doody's Review ServiceAntibiotics Simplified, Fifth Edition is a best-selling, succinct guide designed to bridge knowledge gained in basic sciences courses with clinical practice in infectious diseases. This practical text reviews basic microbiology and how to approach the pharmacotherapy of a patient with a presumed infection. It also contains concise Drug Class Reviews with an explanation of the characteristics of various classes of antibacterial drugs and antifungal drugs.This text simplifies learning infectious disease pharmacotherapy and condenses the many facts that are taught about antibiotics into one quick reference guide. This guide will help students learn the characteristics of antibiotics and why an antibiotic is useful for an indication. With an understanding of the characteristics of the antibiotics, students will be able to make a logical choice to treat an infection more easily.
Автор: Bycroft, Barrie W. Название: Dictionary of Antibiotics and Related Substances ISBN: 1439839522 ISBN-13(EAN): 9781439839522 Издательство: Taylor&Francis Рейтинг: Цена: 137808.00 р. Наличие на складе: Нет в наличии.
Автор: W. Sch?nfeld; H.A. Kirst Название: Macrolide Antibiotics ISBN: 3034894384 ISBN-13(EAN): 9783034894388 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The following group of chapters cover the complex chemistry of the macro- lactone structures, giving historic background, basic structure-activity relation- ships of various derivatization strategies, and perspectives for future discovery of new semisynthetic macrolide antibiotics.
Автор: Istvan F. Pelyvas; Claude Monneret; Pal Herczegh Название: Synthetic Aspects of Aminodeoxy Sugars of Antibiotics ISBN: 3642734014 ISBN-13(EAN): 9783642734014 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The synthetic chemistry of carbohydrates has advanced at a scarcely equalled rate in the last 25 years, due to the great interest of biologically active natural products coritaining sugar moieties.
Автор: Amyes, Sebastian G. B. Название: Magic Bullets, Lost Horizons ISBN: 0415272033 ISBN-13(EAN): 9780415272032 Издательство: Taylor&Francis Рейтинг: Цена: 12248.00 р. Наличие на складе: Нет в наличии.
Автор: David Gottlieb; Paul D. Shaw Название: Mechanism of Action ISBN: 3642460534 ISBN-13(EAN): 9783642460531 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The idea for publishing these books on the mechanism of action and on the biosynthesis of antibiotics was born of frustration in our attempts to keep abreast of the literature. One concept for the books was that they include only antibiotics for which a definitive, well-documented mechanism of action or biosynthetic pathway was known.
Автор: Arnold L. Demain; Nadine A. Solomon Название: Antibiotics ISBN: 3642819680 ISBN-13(EAN): 9783642819681 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Hamao Umezawa; Irving R. Hooper; Y. Ito; Irving R. Название: Aminoglycoside Antibiotics ISBN: 3642685811 ISBN-13(EAN): 9783642685811 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With contributions by numerous experts
Автор: Gabor Lukacs; Masaji Ohno Название: Recent Progress in the Chemical Synthesis of Antibiotics ISBN: 3642756190 ISBN-13(EAN): 9783642756191 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Although, the discovery of most of these agents came from more or less sophisticated screening programs of soil microrganisms, many of the important antibiotics used today in clinical practice are derived from the original biosynthetic products by the application of often novel and generally elaborated chemical synthetic methodologies.
Автор: Conte Название: Manual of Antibiotics and Infectious Diseases ISBN: 0781723167 ISBN-13(EAN): 9780781723169 Издательство: Lippincott Williams & Wilkins Рейтинг: Цена: 5491.00 р. Наличие на складе: Поставка под заказ.
Описание: Manual of Antibiotics and Infectious Diseases: Treatment and Prevention was designed for health-care professionals involved in the daily care of patients with infectious diseases. The book covers antibiotics currently available, their doses, and their dose adjustments. It explains what to do when faced with renal failure, as well as empirical, prophylactic, and definitive antibiotic therapies--everything from bacteria resistance to AIDS therapies. A new section on hospital epidemiology and infection control is included in this Ninth Edition. A Brandon-Hill recommended title.
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