Автор: Dickenson, John (Nottingham Trent University) Free Название: Molecular Pharmacology: From DNA to Drug Discovery ISBN: 0470684437 ISBN-13(EAN): 9780470684436 Издательство: Wiley Рейтинг: Цена: 13161.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Li Название: The Drug Discovery Experience: Practices, Processes, and Perspectives ISBN: 0470942355 ISBN-13(EAN): 9780470942352 Издательство: Wiley Рейтинг: Цена: 12302.00 р. 17574.00-30% Наличие на складе: Есть (1 шт.) Описание: Edited by two distinguished chemists from academia and industry, this book presents an up-to-date overview of major aspects of drug discovery. It covers all ends of the discovery process from target selection to major therapeutic areas.
Автор: Caffrey Название: Parasitic Helminths: Targets, Screens, Drugs and Vaccines ISBN: 3527330593 ISBN-13(EAN): 9783527330591 Издательство: Wiley Рейтинг: Цена: 12856.00 р. 18366.00-30% Наличие на складе: Есть (1 шт.) Описание: The first title dealing with drug discovery against parasitic worms (Helminths) which include many of the major human and animal parasites. The book focusses on the development of novel drugs and vaccination strategies making it attractive for academia and industry alike.
Автор: Jorddy Neves Cruz Название: Drug Discovery and Design Using Natural Products ISBN: 3031352041 ISBN-13(EAN): 9783031352041 Издательство: Springer Цена: 30745.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Historically, natural products have great relevance for the development of new drugs. Natural molecules, in addition to directly providing new compounds with different therapeutic functions have provided scaffolds and a great diversity of structures that serve as inspiration for the design and discovery of new drugs. The great structural complexity and the significant number of natural compounds that can be obtained and their advantages also present some historical problems that need to be overcome. Issues such as difficulty in isolation, difficulty in synthesizing compounds found in nature in the laboratory, screening to evaluate the biological properties of these compounds, and structural optimization to enhance the pharmacological properties of biomolecules; are some of the main difficulties encountered in research with natural products and in the design/discovery of new medicines. Therefore, this book addresses the great scientific advances that provide practical solutions to using natural products to develop new drugs. We address topics related to the genesis of research projects that use natural products to design new drugs. We address the discovery of new species, initial processes for identification and extraction of compounds, isolation and identification of these structures, techniques, and advances in vitro and in vivo methods that support the discovery of new natural drugs, synthesis of new compounds from natural molecules, in silico optimization processes of potentially promising compounds.
Автор: Gore Название: Computational Drug Discovery and Design ISBN: 1493977555 ISBN-13(EAN): 9781493977550 Издательство: Springer Рейтинг: Цена: 12577.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume details methods and techniques for identification of drug targets, binding sites prediction, high-throughput virtual screening,and prediction of pharmacokinetic properties using computer based methodologies. Chapters guide readers through techniques of the available computational tools, developing prediction models for drug target prediction and de novo design of ligands, structure based drug designing, fragment-based drug designing, molecular docking, and scoring functions for assessing protein-ligand docking protocols. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Computational Drug Discovery and Design aims to provide protocols for the use of bioinformatics tools in drug discovery and design.
Автор: Martinez Ana Название: Emerging Drugs and Targets for Multiple Sclerosis ISBN: 1788014502 ISBN-13(EAN): 9781788014502 Издательство: Royal Society of Chemistry Рейтинг: Цена: 33581.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: An ideal reference for any student or researcher interested in drug development for neurodegenerative diseases, autoimmune diseases and MS in particular.
This book is a fascinating overview of one of the first pharmacogenetic traits to be identified as responsible for genetic variation in response to drugs -- the understanding of the arylamine N-acetyltransferases (NATs) is linked to many important therapeutic areas, particularly tuberculosis and also cancer. NATs have been important in the metabolism of established anti-tubercular drugs and also in carcinogenesis and susceptibility to bladder cancer. The reach of these enzymes spans pharmacology and therapeutics as well as toxicology and pharmacogenetics. The NAT genes are encoded in a highly polymorphic region of the human genome which has been explored for fine mapping in molecular anthropological studies.
The book takes a wide ranging approach covering all aspects of the arylamine N-acetyltransferases from genetics to the chemistry and structural biology of the enzymes in the organisms in which they are found, from humans to bacteria and fungi where they appear to have distinct roles. The coverage is by experts in the field from across the globe.
Автор: Puratchikody A., Prabu S. Lakshmana, Umamaheswari A. Название: Computer Applications in Drug Discovery and Development ISBN: 1522573267 ISBN-13(EAN): 9781522573265 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 31977.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With more restrictions upon animal experimentations, pharmaceutical industries are currently focusing on a new generation of experiments and technologies that are considerably more efficient and less controversial. The integration of computational and experimental strategies has led to the identification and development of promising compounds.Computer Applications in Drug Discovery and Development is a pivotal reference source that provides innovative research on the application of computers for discovering and designing new drugs in modern molecular biology and medicinal chemistry. While highlighting topics such as chemical structure databases and dataset utilization, this publication delves into the current panorama of drug discovery, where high drug failure rates are a major concern and properly designed virtual screening strategies can be a time-saving, cost-effective, and productive alternative. This book is ideally designed for chemical engineers, pharmacists, molecular biologists, students, researchers, and academicians seeking current research on the unexplored avenues and future perspectives of drug design.
Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and Dengue, and more.
In addition, Quinoline and Isoquinoline alkaloids for developing new antiprotozoal agents are discussed, alongside anti-trypanosomatid heterocyclic compounds as structures for development. Combining the expertise of specialists from around the world, this volume aims to support and encourage researchers in the investigation of natural sources as starting points for the development of novel, safe and effective agents for use against neglected tropical diseases.
Includes chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery
Draws together cutting-edge research advances in natural product chemistry that are targeted at neglected tropical diseases
Highlights the future potential of natural products as sources of novel medicinal compounds against neglected tropical diseases
Название: Theranostics and Image Guided Drug Delivery ISBN: 178262466X ISBN-13(EAN): 9781782624660 Издательство: Royal Society of Chemistry Рейтинг: Цена: 37805.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book gives an overview of a field where several disciplines have come together towards individualised, safer therapies, and better monitoring of disease and drug action and distribution.
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