Описание: This book proposes a novel concept for molecular recognition. In the field of asymmetric synthesis approaching the mature science, asymmetric discrimination and catalytic synthesis of chiral supramolecules still stand as unsolved problems. The extreme difficulty in asymmetric synthesis of such supramolecules may result from the mobile nature of supramolecular chirality. Here the author shows the first highly enantioselective synthesis of mechanically chiral supramolecules. In the presence of a chiral organocatalyst, a mechanically planar chiral rotaxane was obtained with p erfect enantiopurity (>99% ee) with an excellent selectivity. The dynamic and flexible recognition mode enabled asymmetric synthesis of supramolecules with conformational flexibility and mobility. The recognition mode of the catalyst is a contrast to the traditional static and rigid recognition mode of the typical conventional catalysts. The concept of dynamic molecular recognition will be adopted as a novel concept in a wide range of fields beyond the field of organic chemistry, including material chemistry, biochemistry, and medicinal chemistry.
Автор: Nandi Nilashis Название: Chirality in Biological Nanospaces: Reactions in Active Sites ISBN: 1439840024 ISBN-13(EAN): 9781439840023 Издательство: Taylor&Francis Рейтинг: Цена: 31390.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Chirality is widely studied and omnipresent in biological molecules. However, how the retention of enantiomeric forms persists in many life processes without racemization is still unclear, and the molecular understanding of the stringent chiral specificity in enzymatic reactions is sparse. An overview of the influence of chirality in driving reactions within enzymatic cavities, Chirality in Biological Nanospaces: Reactions in Active Sites covers:
Influences of molecular chirality on the structure of the active site and network of interactions to drive reactions with improved speed, accuracy, and efficiency
The conserved features of the organization of the active site structures of enzymes
The intricate interplay of electrostatic, hydrophobic, and van der Waals interactions
Interactions between the active site residues and the substrate molecules
Despite being time-consuming and expensive, trial-and-error is often the primary method used to develop synthetic enzymes. This book describes methods that combine crystallographic studies with electronic structure-based computational analysis. These methods may lead to future elucidation of new drugs that can target biological active sites with better efficacy and can be used to design custom-made novel biocytes with improved efficiency.
Автор: Nandi Название: Chirality in Biological Nanospaces ISBN: 1138112690 ISBN-13(EAN): 9781138112698 Издательство: Taylor&Francis Рейтинг: Цена: 11482.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Chirality is widely studied and omnipresent in biological molecules. However, how the retention of enantiomeric forms persists in many life processes without racemization is still unclear, and the molecular understanding of the stringent chiral specificity in enzymatic reactions is sparse. An overview of the influence of chirality in driving reactions within enzymatic cavities, Chirality in Biological Nanospaces: Reactions in Active Sites covers:
Influences of molecular chirality on the structure of the active site and network of interactions to drive reactions with improved speed, accuracy, and efficiency
The conserved features of the organization of the active site structures of enzymes
The intricate interplay of electrostatic, hydrophobic, and van der Waals interactions
Interactions between the active site residues and the substrate molecules
Despite being time-consuming and expensive, trial-and-error is often the primary method used to develop synthetic enzymes. This book describes methods that combine crystallographic studies with electronic structure-based computational analysis. These methods may lead to future elucidation of new drugs that can target biological active sites with better efficacy and can be used to design custom-made novel biocytes with improved efficiency.
Автор: Guijarro Albert Название: The Origin of Chirality in the Molecules of Life ISBN: 1839162341 ISBN-13(EAN): 9781839162343 Издательство: Royal Society of Chemistry Рейтинг: Цена: 40060.00 р. Наличие на складе: Нет в наличии.
Описание: This book provides an interdisciplinary review of one of the great unsolved mysteries that has fascinated scientists for over 150 years: the origin of chirality in biomolecules. It is fundamental, comprehensive and structured to be accessible for educational purposes.
Автор: Rudolf Janoschek Название: Chirality ISBN: 3642765718 ISBN-13(EAN): 9783642765711 Издательство: Springer Рейтинг: Цена: 14365.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Les hypotheses, n'en deplaise a mon contradicteur, sont l'ame des progres de la science. Louis Pasteur The concept of chirality, established 100 years ago, plays an im- portant role in almost all domains and dimensions of our recent scientific view of life. Chiral properties can be found in fundamen- tal nuclear particles, in molecules, and in the macroscopic world of living nature (plants and animals) and inanimate nature (crystals). In particular, chirality, or more precisely chiral excess, is evident in human beings. For example, the expected symmetry of the hands turns out to be functionally non-existent. Consequently chirality occurs in the technical sphere, where screws are the best-known examples, since most of them are made for right-handed people. Chirality is not confined to static objects but influences processes such as chemical reactions. The occurrence of chiral objects on different dimensional scales has been treated in the past in mutually independent frameworks. There were, however, two remarkable events from which the conclu- sion can be drawn that the appearance of chirality in various fields has a common cause. On the one hand, physicists found evidence that the well-known biomolecular homochirality can be traced back to the chirality of weak bosons. At the same time, on the other hand, the so-called thalidomide tragedy occurred when thalido- mide molecules of a certain chirality, taken by pregnant women, caused deformed children.
Автор: Imayoshi Название: Discrimination of Mobile Supramolecular Chirality ISBN: 9811674337 ISBN-13(EAN): 9789811674334 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book proposes a novel concept for molecular recognition. In the field of asymmetric synthesis approaching the mature science, asymmetric discrimination and catalytic synthesis of chiral supramolecules still stand as unsolved problems. The extreme difficulty in asymmetric synthesis of such supramolecules may result from the mobile nature of supramolecular chirality. Here the author shows the first highly enantioselective synthesis of mechanically chiral supramolecules. In the presence of a chiral organocatalyst, a mechanically planar chiral rotaxane was obtained with p erfect enantiopurity (>99% ee) with an excellent selectivity. The dynamic and flexible recognition mode enabled asymmetric synthesis of supramolecules with conformational flexibility and mobility. The recognition mode of the catalyst is a contrast to the traditional static and rigid recognition mode of the typical conventional catalysts. The concept of dynamic molecular recognition will be adopted as a novel concept in a wide range of fields beyond the field of organic chemistry, including material chemistry, biochemistry, and medicinal chemistry.
Описание: Biological response modifiers are increasingly used in viral and cancer therapy. Since alterations of the immune system are the primary symptoms of HIV infection, especially therapies directed towards the modulation of the immune response have been under intense evaluation.
Автор: E.C. Tjamos; G.C. Papavizas; R.J. Cook Название: Biological Control of Plant Diseases ISBN: 1475794703 ISBN-13(EAN): 9781475794700 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of a NATO ARW held in Cape Sounion, Greece, May 19-24, 1991
Автор: E.C. Tjamos; G.C. Papavizas; R.J. Cook Название: Biological Control of Plant Diseases ISBN: 0306442302 ISBN-13(EAN): 9780306442308 Издательство: Springer Рейтинг: Цена: 34799.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of a NATO ARW held in Cape Sounion, Greece, May 19-24, 1991
Автор: Jan Je?ek; Jan Hlav??ek; Jaroslav ?ebest?k Название: Biomedical Applications of Acridines ISBN: 3319639528 ISBN-13(EAN): 9783319639529 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer`s disease, Parkinson`s disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine.
Автор: Jan Je?ek; Jan Hlav??ek; Jaroslav ?ebest?k Название: Biomedical Applications of Acridines ISBN: 3319876805 ISBN-13(EAN): 9783319876801 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Нет в наличии.
Описание: This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer`s disease, Parkinson`s disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine.
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