Описание: Case studies have traditionally made up a significant portion of project management education and training. The Kerzner case studies book was planned to package a broad range of case studies in one book to be used in college or professional training courses (as an ancillary to either Kerzner's book or other project management texts). The book has grown to become a very successful product on its own. For this fourth edition Kerzner will add a number of new cases covering value measurement in project management - we will retain the well recevied "super case" which covers all aspects of project management and may be used as a capstone for a course.
A comprehensive introduction to the most important machine learning approaches used in predictive data analytics, covering both theoretical concepts and practical applications.
Machine learning is often used to build predictive models by extracting patterns from large datasets. These models are used in predictive data analytics applications including price prediction, risk assessment, predicting customer behavior, and document classification. This introductory textbook offers a detailed and focused treatment of the most important machine learning approaches used in predictive data analytics, covering both theoretical concepts and practical applications. Technical and mathematical material is augmented with explanatory worked examples, and case studies illustrate the application of these models in the broader business context.
After discussing the trajectory from data to insight to decision, the book describes four approaches to machine learning: information-based learning, similarity-based learning, probability-based learning, and error-based learning. Each of these approaches is introduced by a nontechnical explanation of the underlying concept, followed by mathematical models and algorithms illustrated by detailed worked examples. Finally, the book considers techniques for evaluating prediction models and offers two case studies that describe specific data analytics projects through each phase of development, from formulating the business problem to implementation of the analytics solution. The book, informed by the authors' many years of teaching machine learning, and working on predictive data analytics projects, is suitable for use by undergraduates in computer science, engineering, mathematics, or statistics; by graduate students in disciplines with applications for predictive data analytics; and as a reference for professionals.
Описание: Practical Handbook of Echocardiography: 101 Case Studies Echocardiography is now one of the most commonly used diagnostic imaging tools, yet many clinicians remain unaware of the range of conditions echo can reveal or how echo can be used to help plan th
Описание: For this ready reference, the internationally renowned authority in the field, Roland Kontermann, has assembled a team of outstanding contributors from industry and academia to convey the worldwide knowledge on modifying therapeutic proteins in order to o
Автор: Voynov Название: Therapeutic Proteins ISBN: 1617799203 ISBN-13(EAN): 9781617799204 Издательство: Springer Рейтинг: Цена: 15151 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: After the identification of a potential protein drug, the next critical step is the production of sufficient authentic material for testing, characterization, and clinical trials, which, when successful, leads to the need for robust methodologies for large-scale production, purification, characterization, viral inactivation, and continued testing of the final protein product. Building on the valuable first edition, Therapeutic Proteins: Methods and Protocols, Second Edition aims to cover each of these key aspects of protein drug production through the contributions of authors from highly esteemed industrial and academic institutions around the world. Emphasizing the newest developments in the field, this second edition also includes additional emphasis on discovery, including new display and screening methods as well as the design and engineering of new types of therapeutic proteins. There is also discussion of computational and bioinformatics methods, and chapters on safety aspects of therapeutic protein development. Written in the highly successful Methods in Molecular Biology™ format, protocol chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Fully updated and practical, Therapeutic Proteins: Methods and Protocols, Second Edition provides an essential resource to all scientists working in the field of therapeutic proteins.
Автор: Chamow Название: Therapeutic Fc Fusion Proteins ISBN: 3527333177 ISBN-13(EAN): 9783527333172 Издательство: Wiley Рейтинг: Цена: 13283 р. Наличие на складе: Поставка под заказ.
Описание: Edited by three pioneers in the field – each with longstanding experience in the biotech industry – and a skilled scientific writer, this is the first book to cover every step in the development and production of immunoglobulin Fc-fusion pro
Описание: A comprehensive compilation on plasma protein production from the leading experts in the field, Production of Plasma Proteins for Therapeutic Use presents manufacturing, testing methods, and regulatory issues for plasma-derived therapeutics, a global
Описание: Improve the discovery and development of protein drugs Monoclonal antibodies, as the most successful class of protein therapeutics, have become a critical part of drug treatment regimens with more than 40 marketed modalities and hundreds under development. Some of them have become standards of care, in particular in areas such as oncology and immune–mediated inflammatory diseases; where they often provide safe and efficacious treatment alternatives. Nevertheless, limitations inherent in the canonical monospecific IgG–based monoclonal antibodies have prompted exploration of alternative molecular formats, such as antibody drug–conjugates (ADCs), bi– or multi–specific versions of antibodies. However, there is still scarcity of knowledge and data, combined with a lack of consistent strategies in effectively taking those candidate biologics from preclinical to clinical development. Recent years, though, have seen much progress in understanding ADME (absorption, distribution, metabolism and excretion) of biologics and how this knowledge can be used in research and development.With an emphasis on the theoretical and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement end–to–end translational research. Understanding of ADME has clearly illustrated its merits in the area of small molecule drugs in order to develop drugs successfully and more effectively. Novel therapeutic modalities will even more require an in–depth understanding of ADME to optimize delivery for a successful development. The authors, writing from the frontlines of biologics research and development, cover topics that include similarities and differences in ADME characteristics between small molecules and biologics, the types of therapeutic biologics (e.g. monoclonal antibodies, pegylated proteins, vaccines, ADCs, and bispecifics) and their unique ADME properties, and how protein engineering alters and optimizes ADME and PK/PD properties.A complete and valuable reference and resource for anyone working in the biopharmaceutical field, ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins offers features that include: Concepts of ADME and PK/PD modeling for biologics Comparison of small molecules with biologics, giving a lessons–learned perspective Mechanistic insight in target–driven and local PK/PD in sites of action like tumors and the brain Case studies about leveraging ADME to improve end–to–end biologics drug development Current thinking and strategies on biosimilar development from ADME and PK/PD standpoints Regulatory expectations and industry perspectives for biologic development in USA, EU, and Japan
Автор: Smales C. Mark, James David C. Название: Therapeutic Proteins / Methods and Protocols ISBN: 1588293904 ISBN-13(EAN): 9781588293909 Издательство: Springer Рейтинг: Цена: 20899 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: World-class researchers share their innovative and proven techniques for the production of therapeutic proteins downstream of the discovery stage. The methods use a variety of sources for producing therapeutic proteins, including bacterial and yeast expression systems, and insect and mammalian cells, and then cover the purification of the resulting protein using both state-of-the-art and traditional methods, such as those sourced from plasma. Additional chapters offer methods for the characterization of therapeutic proteins throughout the production process, along with methods and strategies for viral inactivation and protein formulation. The protocols follow the successful Methods in Molecular Biologyв„ў series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Описание: Chromatin Proteins and Transcription Factors as Therapeutic Targets, the latest volume in the Advances in Protein Chemistry and Structural Biology series is an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics.
Автор: Banga Название: Therapeutic Peptides Proteins Formu ISBN: 146656606X ISBN-13(EAN): 9781466566064 Издательство: Taylor&Francis Рейтинг: Цена: 16748 р. Наличие на складе: Поставка под заказ.
Описание: There are more than 500 biopharmaceuticals on the market, including more than 200 therapeutic proteins, making biologics the fastest growing sector in the biopharmaceutical market. These products include more than 40 monoclonal antibodies, for indications ranging from treatment or mitigation of various types of cancer to rheumatoid arthritis. The clinical application of these therapeutic peptides and proteins is limited by several problems, such as lack of physical and chemical stability or the lack of desirable attributes for adequate absorption or distribution. Thus, as these therapeutic peptides and proteins are made available, it will be essential to formulate these drugs into safe, stable, and efficacious delivery systems. The pharmaceutical scientist involved in this effort needs to call upon the knowledge of several disciplines, such as pharmaceutics, medicinal chemistry, biochemistry, microbiology, and chemical engineering and needs to keep abreast with the latest research in the published literature. Therapeutic Peptides and Proteins: Formulation, Processing, and Delivery Systems, Third Edition provides a comprehensive overview of the field for scientists in industry and academia and for students, while also providing practical information on the challenges facing the formulation and delivery aspects of these unique macromolecules. In particular, the book: Explains how recombinant DNA techniques now allow us to produce therapeutic proteins in a commercially viable form Discusses the physical and chemical pathways of peptide and protein degradation Includes a detailed discussion of protein formulation and lyophilization Overviews the pharmacokinetic aspects of therapeutic peptides and proteins and discusses controlled delivery systems for parenteral administration, including microsphere formulations Discusses research progress on oral, transdermal, mucosal, and topical delivery systems discusses transdermal and topical delivery