Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics, Alexander Vinks; Hartmut Derendorf; Johan Mouton (
Автор: Bradley John, Nelson John D. Название: 2015 Nelson`s Pediatric Antimicrobial Therapy, 21st Edition ISBN: 1581109180 ISBN-13(EAN): 9781581109184 Издательство: Eurospan Цена: 4022 р. Наличие на складе: Есть (1 шт.) Описание: Provides instant access to the most up to date recommendations for treatment of all infectious diseases in children. Provides commentary for each disease; drug descriptions cover all antimicrobial agents available and include complete information about dosing regimens.
Автор: Finch, Roger; Davey, Peter; Wilcox, Mark H.; Irvin Название: Antimicrobial Chemotherapy ISBN: 0199697655 ISBN-13(EAN): 9780199697656 Издательство: Oxford Academ Цена: 4162 р. Наличие на складе: Поставка под заказ.
Описание: Antimicrobial agents are essential for the treatment of life-threatening infections and for managing the burden of minor infections in the community. In addition, they play a key role in organ and bone marrow transplantation, cancer chemotherapy, artificial joint and heart valve surgery. Unlike other classes of medicines, they are vulnerable to resistance from mutations in target microorganisms, and their adverse effects may extend to other patients (increased risk of cross-infection). As a consequence, there is a constant requirement for new agents, as well as practices that ensure the continued effective prescribing of licensed agents. Public awareness and concerns about drug resistant organisms has led to widespread publicity and political action in the UK, Europe and worldwide. The control of drug resistance and the implementation of good prescribing practice are now legal requirements in the UK as a result of the UK Health Act (2008). These fundamental changes underscore the ne
Автор: Greenwood Название: Antimicrobial Chemotherapy 5/e P. 2007 ISBN: 0198570163 ISBN-13(EAN): 9780198570165 Издательство: Oxford Academ Рейтинг: Цена: 4158 р. Наличие на складе: Поставка под заказ.
Описание: Aims to encourage good prescribing habits in doctors throughout the world, by describing the basic properties of antibiotics and other antimicrobial agents, and discussing the principles underlying the rational use of antimicrobial agents in the management of infection.
Название: Antimicrobial therapeutics reviews ISBN: 1573317888 ISBN-13(EAN): 9781573317887 Издательство: Wiley Рейтинг: Цена: 9400 р. Наличие на складе: Поставка под заказ.
Описание: This is the inaugural volume in a new series of reviews. Each annual volume will contain authoritative reviews of developing research topics in antimicrobial therapeutics. Authors will describe how the research being reviewed can be applied to real?
Автор: Amyes Название: Antimicrobial Chemotherapy ISBN: 1853173894 ISBN-13(EAN): 9781853173899 Издательство: Informa Цена: 5204 р. Наличие на складе: Нет в наличии.
Описание: One of a series of pocketbooks designed to provide easily assimilable information on common medical issues. The concise texts are enhanced by tables and
diagrams summarizing the essential information. This volume deals with antimicrobial therapy.
Автор: Douglas L. Mayers (Ed.) Название: Antimicrobial Drug Resistance Handbook ISBN: 1588294056 ISBN-13(EAN): 9781588294050 Издательство: Springer Рейтинг: Цена: 21412 р. Наличие на складе: Поставка под заказ.
Описание: This handbook is the first comprehensive reference on antimicrobial drug resistance. The first volume is devoted to the biological basis of drug resistance and effective drug development. The second volume covers the clinical aspects of drug resistance.
A comprehensive textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics
"The field's leading text for more than three decades"
"Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition" provides you with a basic understanding of the principles of biopharmaceutics and pharmacokinetics and applies these principles to drug product development, drug product performance and drug therapy. The revised and updated sixth edition is unique in teaching basic concepts that relate to understanding the complex issues associated with safe and efficacious drug therapy.
Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics will help you to: Understand the basic concepts in biopharmaceutics and pharmacokinetics. Use raw data and derive the pharmacokinetic models and parameters that best describe the process of drug absorption, distribution, and elimination Critically evaluate biopharmaceutic studies involving drug product equivalency and unequivalency Design and evaluate dosage regimens of drugs, using pharmacokinetic and biopharmaceutic parameters Detect potential clinical pharmacokinetic problems and apply basic pharmacokinetic principles to solve them
Practical problems and clinical examples with discussions are included in each chapter to help you apply these principles to patient care and drug consultation situations. Chapter Objectives, Chapter Summaries, and Frequently Asked Questions along with additional application questions appear within each chapter to identify and focus on key concepts. Most of the chapters have been revised to reflect our current understanding of drug product performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy.
Автор: Tozer Thomas N Название: Essentials of Pharmacokinetics and Pharmacodynamics ISBN: 1451194420 ISBN-13(EAN): 9781451194425 Издательство: Lippincott Williams & Wilkins Рейтинг: Цена: 4985 р. 5539.00-10% Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This unique text helps students and healthcare professionals master the fundamentals of pharmacokinetics and pharmacodynamics. Written by distinguished international experts, it provides readers with an introduction to the basic principles underlying the establishment and individualization of dosage regimens and their optimal use in drug therapy. Up-to-date examples featuring currently prescribed drugs illustrate how pharmacokinetics and pharmacodynamics relate to contemporary drug therapy. Study problems at the end of each chapter help students and professionals gain a firm grasp of the material covered within the text.
Описание: Improve the discovery and development of protein drugs Monoclonal antibodies, as the most successful class of protein therapeutics, have become a critical part of drug treatment regimens with more than 40 marketed modalities and hundreds under development. Some of them have become standards of care, in particular in areas such as oncology and immune–mediated inflammatory diseases; where they often provide safe and efficacious treatment alternatives. Nevertheless, limitations inherent in the canonical monospecific IgG–based monoclonal antibodies have prompted exploration of alternative molecular formats, such as antibody drug–conjugates (ADCs), bi– or multi–specific versions of antibodies. However, there is still scarcity of knowledge and data, combined with a lack of consistent strategies in effectively taking those candidate biologics from preclinical to clinical development. Recent years, though, have seen much progress in understanding ADME (absorption, distribution, metabolism and excretion) of biologics and how this knowledge can be used in research and development.With an emphasis on the theoretical and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement end–to–end translational research. Understanding of ADME has clearly illustrated its merits in the area of small molecule drugs in order to develop drugs successfully and more effectively. Novel therapeutic modalities will even more require an in–depth understanding of ADME to optimize delivery for a successful development. The authors, writing from the frontlines of biologics research and development, cover topics that include similarities and differences in ADME characteristics between small molecules and biologics, the types of therapeutic biologics (e.g. monoclonal antibodies, pegylated proteins, vaccines, ADCs, and bispecifics) and their unique ADME properties, and how protein engineering alters and optimizes ADME and PK/PD properties.A complete and valuable reference and resource for anyone working in the biopharmaceutical field, ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins offers features that include: Concepts of ADME and PK/PD modeling for biologics Comparison of small molecules with biologics, giving a lessons–learned perspective Mechanistic insight in target–driven and local PK/PD in sites of action like tumors and the brain Case studies about leveraging ADME to improve end–to–end biologics drug development Current thinking and strategies on biosimilar development from ADME and PK/PD standpoints Regulatory expectations and industry perspectives for biologic development in USA, EU, and Japan
Описание: This book provides a comprehensive foundation for the contemporary application of pharmacokinetics and pharmacodynamics. The second edition updates and strengthens existing chapters and adds new topics to address current needs including physiologically based pharmacokinetic modeling, pharmacogenomics and predicting drug-drug interactions.
Описание: Discusses mass spectrometry (MS) in drug metabolism and pharmacokinetic studies. This book reviews MS techniques and applications and describes various methods for using MS in drug metabolism studies and pharmacokinetics. It is suitable for scientists in the pharmaceutical industry, medicine, academia, and even those working in homeland defense.
Автор: Nightingale Charles H Название: Antimicrobial Pharmacodynamics ISBN: 0824729250 ISBN-13(EAN): 9780824729257 Издательство: Taylor&Francis Цена: 14003 р. Наличие на складе: Поставка под заказ.
Описание: Taking readers from the research laboratory to the bedside, this Second Edition compiles essential information on the pharmacodynamics of all major classes of the antimicrobial armamentarium including penicillins, cephalosposorins, cephamycins, carbapenems, monobactams, aminoglycosides, quinolones, macrolides, antifungals, antivirals, and emerging agents currently in development. Written by experienced professionals in the field, this guide uses an abundance of examples to depict methods to apply pharmacodynamic concepts to everyday clinical practice.
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