New Technologies for Toxicity Testing, Balls, Michael; Combes, Robert D.; Bhogal, Nirmala (Eds.)

Автор: Peter Greaves
Название: Histopathology of Preclinical Toxicity Studies,
ISBN: 0444538569 ISBN-13(EAN): 9780444538567
Издательство: Elsevier Science
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Описание: Describes the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. This reference is suitable for those involved in drug safety evaluation, including pathologists, toxicologists, and pharmacologists.

Автор: Eskes
Название: Validation of Alternative Methods for Toxicity Testing
ISBN: 3319338242 ISBN-13(EAN): 9783319338248
Издательство: Springer
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Описание: This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway-based concepts in toxicology. Validation of Alternative Methods for Toxicity Testing is divided into two sections, in the first, practical insights are given on the state-of-the-art and on approaches that have resulted in successfully validated and accepted alternative methods. The second section focuses on the evolution of validation principles and practice that are necessary to ensure fit-for-purpose validation that has the greatest impact on international regulatory acceptance of alternative methods. In this context validation needs to keep pace with the considerable scientific advancements being made in toxicology, the availability of sophisticated tools and techniques that can be applied in a variety of ways, and the increasing societal and regulatory demands for better safety assessment. This book will be a useful resource for scientists in the field of toxicology, both from industry and academia, developing new test methods, strategies or techniques, as well as Governmental and regulatory authorities interested in understanding the principles and practicalities of validation of alternative methods for toxicity testing.

Автор: Goldstein
Название: Mechanisms of Injury in Renal Disease and Toxicity
ISBN: 0849388732 ISBN-13(EAN): 9780849388736
Издательство: Taylor&Francis
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Описание: Dr. Goldstein has authored more than 50 publications and co-edited two books. Her latest contribution to the field of nephrology, Mechanisms of Injury in Renal Disease and Toxicity, promotes an understanding of the pathophysiologic mechanisms mediating renal dysfunction in disease