Heart disease is the leading cause of death in the UK and the United States. For those people who survive heart disease, few victims recover completely. Cell therapies, tissue engineering and biomaterials technologies have advanced and now offer the potential to reverse the damage caused by heart disease.
Volume 1 of this important book provides readers with comprehensive information on biomaterials and tissue engineering as strategies for the repair and regeneration of the heart. The book begins with an introduction to the field, and following chapters look at biomaterials for regeneration and repair of the heart. Further chapters discuss tissue engineering strategies for the regeneration and repair of the heart whilst the final chapters review vascular modelling and regeneration.
Volume 2 reviews the use of biomaterials, alone or combined with cell therapy, to provide tissue engineered constructs to repair the injured heart and prevent or reverse heart failure.
Автор: Engel, Felix B. Название: Heart Regeneration: Stem Cells & Beyond ISBN: 9814299804 ISBN-13(EAN): 9789814299800 Издательство: World Scientific Publishing Рейтинг: Цена: 13964 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Injured mammalian hearts do not regenerate but scar. This is a major medical problem, as ischemic heart disease is among the leading causes of morbidity and mortality worldwide. Essential clues for human heart repair are uncovered when zebrafish and newt are found to regenerate cardiac muscle after injury.This book presents the major advances of the last decade in the field of cardiac regeneration. These recent advances include: demonstration that zebrafish, a genetically tractable system, can regenerate heart; the identification of several new stem cell populations in the heart; demonstration that stem cells can be used to improve heart function; and demonstration that induction of cardiomyocyte proliferation is a realistic future option to repair injured hearts. This book also provides detailed reviews of the research on model organisms capable of heart regeneration as well as innovative translational research to achieve regeneration in mammals, that comprises work on blood born stem cells, endogenous cardiac stem cells, paracrine factors, reawakening of cardiomyocyte proliferation, and bioengineering. More importantly, the book, in the concluding chapter, dovetails the studies with a comprehensive overview of clinical trials.
Автор: Nadia Rosenthal Название: Heart Development and Regeneration, ISBN: 0123813328 ISBN-13(EAN): 9780123813329 Издательство: Elsevier Science Рейтинг: Цена: 16830 р. Наличие на складе: Поставка под заказ.
Описание: The development of the cardiovascular system is a rapidly advancing area in biomedical research, now coupled with the burgeoning field of cardiac regenerative medicine. A lucid understanding of these fields is paramount to reducing human cardiovascular diseases of both fetal and adult origin. Significant progress can now be made through a comprehensive investigation of embryonic development and its genetic control circuitry.Heart Development and Regeneration, written by experts in the field, provides essential information on topics ranging from the evolution and lineage origins of the developing cardiovascular system to cardiac regenerative medicine. A reference for clinicians, medical researchers, students, and teachers, this publication offers broad coverage of the most recent advances.Volume One discusses heart evolution, contributing cell lineages; model systems; cardiac growth; morphology and asymmetry; heart patterning; epicardial, vascular, and lymphatic development; and congenital heart diseases.Volume Two includes chapters on transcription factors and transcriptional control circuits in cardiac development and disease; epigenetic modifiers including microRNAs, genome-wide mutagenesis, imaging, and proteomics approaches; and the theory and practice of stem cells and cardiac regeneration.
Описание: This book is the definitive reference on two of the most exciting areas of cardiovascular research - myocardial regeneration and stem cell therapy - for the treatment of disease. Edited by pioneers in the area, with contributions from every major inve
Автор: Lee Название: Stem Cells for Myocardial Regeneration ISBN: 1607617048 ISBN-13(EAN): 9781607617044 Издательство: Springer Рейтинг: Цена: 13557 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Explores the developments in the field of regenerative medicine, focusing both on the benefits of using stem cells in myocardial repair and regeneration and on the challenges associated with making this a mainstream therapy. This title examines the developmental processes of the human heart in order to develop strategies for regeneration.
Автор: Penn Название: Stem Cells & Myocardial Regeneration. 2007 ISBN: 1588296644 ISBN-13(EAN): 9781588296641 Издательство: Springer Рейтинг: Цена: 21412 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Presents the state of knowledge of cell based myocardial regeneration including focuses on findings in both the laboratory and the clinic trials. This book focuses on the magnitude of the problem of congestive heart failure diagnosed each year; followed by sections on the science behind cell based myocardial regeneration.
Автор: Marc S. Penn Название: Stem Cells and Myocardial Regeneration ISBN: 1617377058 ISBN-13(EAN): 9781617377051 Издательство: Springer Рейтинг: Цена: 21412 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Over the past 5 years there has been great excitement and controversy in the scientific, financial, and lay literature for the potential of stem cell-based strategies for the prev- tion and treatment of chronic heart failure (CHF).
Автор: Ren-Ke Li Название: Cardiac Regeneration And Repair,1 ISBN: 0857096583 ISBN-13(EAN): 9780857096586 Издательство: Elsevier Science Рейтинг: Цена: 15989 р. 17765.00-10% Наличие на складе: Поставка под заказ.
Описание: Cardiac Regeneration and Repair, Volume One reviews the pathology of cardiac injury and the latest advances in cell therapy. Chapters in part one explore the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function. Part two highlights new approaches to cell therapy for cardiac regeneration, and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac function. Chapters in part three move on to highlight novel stem cells for cardiac repair, including human embryonic stem cells and human pluripotent stem cells, and detail their current status and future potential for cardiac therapy. Finally, part four explores gene therapy, and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration. Cardiac Regeneration and Repair, Volume One is complemented by a second volume covering biomaterials and tissue engineering. Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials.
Автор: Ren-Ke Li Название: Cardiac Regeneration and Repair,2 ISBN: 0857096591 ISBN-13(EAN): 9780857096593 Издательство: Elsevier Science Рейтинг: Цена: 16830 р. 18700.00-10% Наличие на складе: Поставка под заказ.
Описание: Cardiac Regeneration and Repair, Volume Two reviews the use of biomaterials, alone or combined with cell therapy, in providing tissue-engineered constructs to repair the injured heart and prevent or reverse heart failure. Part one explores the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. Further chapters explore the use of biomaterials to enhance stem cell therapy for restoring ventricular function and generating stem cell-modified intravascular stents. Part two focuses on tissue engineering for cardiac repair, including chapters on decellularized biologic scaffolds, synthetic scaffolds, cell sheet engineering, maturation of functional cardiac tissue patches, vascularized engineered tissues for in vivo and in vitro applications, and clinical considerations for cardiac tissue engineering. Finally, part three explores vascular remodeling, including chapters highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels. Cardiac Regeneration and Repair, Volume Two is complemented by an initial volume covering pathology and therapies. Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials.
Описание: The fact that the cardiovascular system transports oxygen and nutrients to all parts of the body makes any threat to its well-being a serious hazard to organs, tissues, and cells. This fundamental truth underlines the importance of research into cardiovascular regeneration and, therefore, of this collection outlining the latest developments in the field. With input from many of the leading researchers and practitioners, this book describes techniques for therapeutic angiogenesis and vasculogenesis for the treatment of ischemic diseases and examines the current approaches to angiogenic cytokines, cardiovascular stem cells, and tissue-engineering tools. The latest clinical results using bone marrow-derived mononuclear cell therapy for intractable circulatory disorders are also covered. This body of work will be a valuable resource for professionals in the fields of cardiovascular surgery, regenerative medicine, and tissue engineering.
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