The Immunogenetics of Autoimmune Diseases, Volume I, Farid
Автор: Farid Название: The Immunogenetics of Autoimmune Diseases, Volume II ISBN: 0849368987 ISBN-13(EAN): 9780849368981 Издательство: Taylor&Francis Рейтинг: Цена: 65076.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Many developments in immunology have occurred over the past 10 years that give us a better understanding of the immune system and its dysfunctions
Автор: Ian R. Mackay Название: The Autoimmune Diseases, ISBN: 0123849292 ISBN-13(EAN): 9780123849298 Издательство: Elsevier Science Рейтинг: Цена: 25791.00 р. Наличие на складе: Поставка под заказ.
Описание: Since publication of the 4th Edition of The Autoimmune Diseases in 2006, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This fully revised 5th Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels and includes expanded coverage of autoinflammatory disease and autoimmune responses to tumors.
Автор: Jorge R. Oksenberg; David Brassat Название: Immunogenetics of Autoimmune Disease ISBN: 1489997482 ISBN-13(EAN): 9781489997487 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: utoimmunity is the downstream outcome of a rather extensive and coordinated series of events that include loss of self-tolerance, peripheral lymphocyte Aactivation, disruption of the blood-systems barriers, cellular infiltration into the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extent conditioned by the unique amino acid sequences that define allelic variants on each of the numerous participating mol ecules. Therefore, the coding genes in their germline configuration play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy. Although genetic components in these diseases are clearly present, the lack of obvious and homogeneous modes of transmission has slowed progress by prevent ing the full exploitation of classical genetic epidemiologic techniques. Furthermore, autoimmune diseases are characterized by modest disease risk heritability and m- tifaceted interactions with environmental influences. Yet, several recent discoveries have dramatically changed our ability to examine genetic variation as it relates to human disease. In addition to the development of large-scale laboratory methods and tools to efficiently recognize and catalog DNA diversity, over the past few years there has been real progress in the application of new analytical and data-manage ment approaches.
Описание: Inflammatory disorders of the nervous system, although individually uncommon, collectively make up 10-20% of acute paediatric neurology presentations and many are potentially treatable Provides a detailed and comprehensive summary of the childhood diseases that are caused by the immune system and their treatments .
Описание: Only in very recent times have therapies been developed that are specific to a particular manifestation of autoimmune disease, and these have begun to replace the all-purpose remedies of the past 30 years.
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