Jorge R. Oksenberg; David Brassat Immunogenetics of Autoimmune Disease 9781489997487

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Автор: Jorge R. Oksenberg; David Brassat
Название: Immunogenetics of Autoimmune Disease
ISBN: 9781489997487
Издательство: Springer
Классификация:

Медицинское оборудования и методики его эксплуатации

Медицинские исследования

Медицинская генетика

Иммунология

ISBN-10: 1489997482
Обложка/Формат: Paperback
Страницы: 172
Вес: 0.27 кг.
Дата издания: 2006
Серия: Medical Intelligence Unit
Язык: English
Издание: 2006 ed.
Иллюстрации: 25 tables, black and white; xi, 158 p.
Размер: 234 x 156 x 9
Читательская аудитория: Professional & vocational
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: utoimmunity is the downstream outcome of a rather extensive and coordinated series of events that include loss of self-tolerance, peripheral lymphocyte Aactivation, disruption of the blood-systems barriers, cellular infiltration into the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extent conditioned by the unique amino acid sequences that define allelic variants on each of the numerous participating mol ecules. Therefore, the coding genes in their germline configuration play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy. Although genetic components in these diseases are clearly present, the lack of obvious and homogeneous modes of transmission has slowed progress by prevent ing the full exploitation of classical genetic epidemiologic techniques. Furthermore, autoimmune diseases are characterized by modest disease risk heritability and m- tifaceted interactions with environmental influences. Yet, several recent discoveries have dramatically changed our ability to examine genetic variation as it relates to human disease. In addition to the development of large-scale laboratory methods and tools to efficiently recognize and catalog DNA diversity, over the past few years there has been real progress in the application of new analytical and data-manage ment approaches.
Дополнительное описание: HLA and Autoimmunity.- Genomic Variation and Autoimmune Disease.- Endocrine Diseases.- Endocrine Diseases.- Central and Peripheral Nervous System Diseases.- Immunogenetics of Rheumatoid Arthritis, Systemic Sclerosis and Systemic Lupus Erythematosus.- Gast

Immunogenetics of Autoimmune Disease, Jorge R. Oksenberg; David Brassat