NF-kB/Rel Transcription Factor Family, Hsiou-Chi Liou

Автор: Cox
Название: Australian English Pronunciation and Transcription
ISBN: 0521145899 ISBN-13(EAN): 9780521145893
Издательство: Cambridge Academ
Рейтинг:
Цена: 10454.00 р.
Наличие на складе: Нет в наличии.

Описание: Australian English Pronunciation and Transcription is the first textbook to clearly describe the speech of Australians. This groundbreaking work addresses Australian English pronunciation characteristics and provides detailed instruction in both phonetic and phonemic transcription of the dialect. Through comprehensive coverage of traditional and revised systems of phonemic transcription, Australian English Pronunciation and Transcription offers an astute and engaging exploration of one of the core global dialects of English. Australian English Pronunciation and Transcription is complemented by an extensive Website which provides further explanatory materials and exercises with audio examples. This unique text, in tandem with these valuable pedagogical features, is an essential resource for students and teachers of linguistics, speech pathology and language education.

Автор: Robert N. Eisenman
Название: The Myc/Max/Mad Transcription Factor Network
ISBN: 3642421415 ISBN-13(EAN): 9783642421419
Издательство: Springer
Рейтинг:
Цена: 27950.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Scientists often look askance at their colleagues whose research appears too strongly focused on a single gene or gene product. We are supposed to be interested in the “big picture” and excessive zeal in pursuit of a single pixel might seem to border on an obsession that is likely to yield only details. However as this volume of Current Topics in Microbiology and Immunology demonstrates, this is certainly not the case for myc. Intense study of this en- matic proto-oncogene over the last twenty years has only broadened our view of its functions and led to insights into mechanisms relating to transcriptional regulation as well as to cell growth, proliferation, differentiation, apoptosis and organismal development. The myc gene originally came to light as a retroviral oncogene (v-myc) associated with a wide range of acute neoplasms. It was later shown to be a virally transduced cellular gene (c-myc) which is a member of family of on- genes (c-myc,N-myc,L-myc). These family members are themselves subject to a bewildering assortment of genetic rearrangements associated with many different types of tumors derived from many different types of cells. These rearrangements (including chromosomal translocation, viral integration, and gene ampli?cation) act to uncouple expression of the myc family genes from their normal physiological regulators. The chapter by LIU and LEVENS - scribes the key pathways leading to regulation of myc expression, showing that such regulation occurs at several different levels and through multiple mechanisms.