Metastasis of Prostate Cancer, Richard J. Ablin; Malcolm D. Mason

Автор: Beauchemin
Название: Metastasis of Colorectal Cancer
ISBN: 9048188326 ISBN-13(EAN): 9789048188321
Издательство: Springer
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Цена: 28734.00 р.
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Описание: This book covers colon cancer metastasis from fundamental aspects to clinical practice. Major topics include physiopathology, genetic and epigenetic controls, cancer initiating cells, epithelial-mesenchymal transition, growth factors and signalling, and more.

Название: Prostate cancer
ISBN: 0521887046 ISBN-13(EAN): 9780521887045
Издательство: Cambridge Academ
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Цена: 14731.00 р.
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Описание: Prostate cancer is one of the most common malignancies in men in the Western world. Although a wide range of treatment regimens are available for this disease, there are few evidence-based guidelines for treatment selection. This volume describes the clinical value of imaging for improving not only staging and treatment selection, but also the diagnosis, treatment planning, and treatment follow-up for patients with prostate cancer. A multidisciplinary disease management approach is critical in this disease. For the radiologist, understanding the pathophysiology, critical clinical issues, and advantages and limitations of different treatments is essential for meaningful interpretation of imaging studies. Similarly, for the practising clinician, understanding the advantages and limitations of imaging modalities and the importance of optimal technique are crucial to the rational use of imaging. This volume serves as a valuable reference for radiologists, urologists, medical and radiation oncologists and all practitioners involved in the management of prostate cancer.

Автор: Steven A. Stacker; Marc G. Achen
Название: Lymphangiogenesis in Cancer Metastasis
ISBN: 940073042X ISBN-13(EAN): 9789400730427
Издательство: Springer
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Цена: 32004.00 р.
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Описание: The book covers all aspects of the new field of lymphatic vessel growth from the fundamental role that protein growth factors and their receptors play in lymphangiogenesis to the potential application of these advances to cancer diagnosis and treatment.

Автор: Stanley P. L. Leong
Название: Cancer Metastasis and the Lymphovascular System:
ISBN: 1489991026 ISBN-13(EAN): 9781489991027
Издательство: Springer
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Цена: 27950.00 р.
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Описание: Sentinel lymph node (SLN) procedures have opened a window of opportunity for the study of micrometastasis. In eighty percent (80%) of metastasis there lies an orderly pattern of progression via the lymphatic network, while 20% of the time systemic metastasis occurs, bypassing the lymphatic system. During the past two decades, significant progress has been achieved in understanding the anatomical, functional, cellular and molecular aspects of the lymphovascular system and the metastasis process. · Molecular imaging advances help to localize early cancers more precisely. · Current status of the immune responses in the draining lymph nodes against cancer is summarized. · New paradigms of early cancer growth, proliferation, overcoming apoptosis are exploited in the development of anticancer treatment. In this book, basic scientists and clinicians exchange ideas so that laboratory findings can be applied to clinical dilemmas, and clinical problems can be targeted for research in the laboratory.

Автор: Wen-Sheng Wu; Chi-Tan Hu
Название: Signal Transduction in Cancer Metastasis
ISBN: 9400733585 ISBN-13(EAN): 9789400733589
Издательство: Springer
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Цена: 27951.00 р.
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Описание: This book examines the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. It highlights the initial stage of tumor metastasis.

Автор: Beauchemin
Название: Metastasis of Colorectal Cancer
ISBN: 9400732937 ISBN-13(EAN): 9789400732933
Издательство: Springer
Цена: 28732.00 р.
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Описание: Introduction; N. Beauchemin, J. Huot 1. The Metastatic Process: an Overview; N.Porquet, S. Guot, J. Huot 1.1 Models of metastasis - 1.1.1 The progression model - 1.1.2 The transient compartment model - 1.1.3 The early oncogenesis model - 1.1.4 The fusion model - 1.1.5 The gene transfer models - 1.1.6 The genetic predisposition model 1.2 Metastatic steps - 1.2.1 Development of the primary colorectal cancer - 1.2.1.1 Initiation of the primary neoplasm - 1.2.1.2 Influence of stromal cells - 1.2.1.3 Influence of the extracellular matrix - 1.2.1.4 Epithelial-Mesenchymal transition - 1.2.1.5 Angiogenesis and lymphangiogenesis - 1.2.2 Intravasation - 1.2.3 Circulation of cancer cells - 1.2.4 Extravasation - 1.2.4.1 The adhesion on endothelial cells and the homing concept of metastasis - 1.2.4.2 The passage across the endothelium 1.2.5 Colonization of the secondary sites 1.3 Concluding Remarks References 2. Physiopathology of Colorectal Metastasis; C. Ferrario, M. Basik 2.1 Mechanisms of metastatic spread - 2.1.1 Circulatory spread - 2.1.1.1 Lymphatic spread - 2.1.1.2 Hematogenous spread - 2.1.2 Local spread - 2.1.3 Tumour dormancy 2.2 Sites of metastasis and consequences of spread - 2.2.1 Liver - 2.2.1.1 Steps in liver invasion - 2.2.1.2 Development of liver failure - 2.2.2 Lungs - 2.2.3 Peritoneum - 2.2.4 Bone and bone marrow - 2.2.5 Brain metastasis 2.3 factors contributing to metastatic spread - 2.3.1 Tumour factors - 2.3.1.1 Tissue Factor - 2.3.1.2 EGFR - 2.3.2 Host factors - 2.3.2.1 Immunity - 2.3.2.2 Diet, exercise and liver disease - 2.3.3 Iatrogenic factors 2.4 Conclusion References 3. The Genetic of Colorectal Cancer; A.M. Kaz, W.M. Grady 3.1 Introduction 3.2 The Adenoma-to-Carcinoma Sequence 3.3 Genomic Instability - 3.3.1 Overview - 3.3.2 Chromosome Instability - 3.3.3 DNA Mismatch Repair Inactivation and Microsatellite Instability - 3.3.4 Base Excision Repair Defects/MYH 3.4 Common Deregulated Signalling Pathways - 3.4.1 Wingless/Wnt Signalling Pathway - 3.4.1.1 APC - 3.4.1.2 B-Catenin (CTNNB1) - 3.4.2 KRAS, BRAF and RAS-RAF-MAPK Signalling Pathway - 3.4.2.1 K-RAS - 3.4.2.2 BRAF - 3.4.3 p53 (TP53) - 3.4.4 The Phosphatidylinositol 3-kinase (PI3K) Pathway - 3.4.4.1 PIK3CA - 3.4.4.2 PTEN - 3.4.5 TGF-B Signalling Pathways - 3.4.5.1 TGFBR2 - 3.4.5.2 The SMAD Family of Genes - 3.4.5.3 TGF-B Superfamily Receptors: ACVR2 and BMPR1A 3.5 Genome-Wide Analyses of Colorectal Cancer Genes 3.6 Metastasis Genes 3.7 Conclusions References 4. Epigenetics of Colorectal Cancer; F.J. Carmona, M. Esteller 4.1 Introduction 4.2 DNA methylation defects in colorectal cancer - 4.2.1 Hypomethylation of DNA 4.3 Inactivation of tumour suppressor genes by CpG island hypermethylation 4.4 Epigenetic regulation of microRNA in cancer 4.5 MicroRNAs as metastasis switches 4.6 Histone modification defects in colon cancer 4.7 Epigenetic contribution to co