The Glutamate Receptors, Robert W. Gereau; Geoffrey Swanson

Автор: Gavril Pasternak
Название: The Opiate Receptors
ISBN: 1617797219 ISBN-13(EAN): 9781617797217
Издательство: Springer
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Цена: 36570.00 р.
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Описание: This fully revised and expanded second edition covers the latest research on opiate receptors and related receptor subtypes. It discusses topics relevant to correlating the biochemical, physiological and pharmacological aspects of opiate reaction.

Автор: Arne Schousboe; Ursula Sonnewald
Название: The Glutamate/GABA-Glutamine Cycle
ISBN: 3319450948 ISBN-13(EAN): 9783319450940
Издательство: Springer
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Цена: 23508.00 р.
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Описание: Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term “The Glutamate-Glutamine Cycle.” In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book.