Arne Schousboe; Ursula Sonnewald The Glutamate/GABA-Glutamine Cycle 9783319450940

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Автор: Arne Schousboe; Ursula Sonnewald
Название: The Glutamate/GABA-Glutamine Cycle
ISBN: 9783319450940
Издательство: Springer
Классификация:

Науки о жизни (медико-биологические): общие вопросы

Нейронауки

ISBN-10: 3319450948
Обложка/Формат: Hardback
Страницы: 416
Вес: 0.80 кг.
Дата издания: 2016
Серия: Advances in neurobiology
Язык: English
Иллюстрации: 13 black & white illustrations, 42 colour illustrations, 25 colour tables, biography
Размер: 234 x 156 x 24
Читательская аудитория: Professional & vocational
Подзаголовок: Amino acid neurotransmitter homeostasis
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term “The Glutamate-Glutamine Cycle.” In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book.

A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction.

Дополнительное описание: ?Introduction to the Glutamate-Glutamine cycle.- Glucose, lactate, ?-hydroxybutyrate, acetate, GABA, and succinate as substrates for synthesis of glutamate and GABA in the glutamine-glutamate/GABA cycle.- Anaplerosis for glutamate synthesis in the neonate

The Glutamate/GABA-Glutamine Cycle, Arne Schousboe; Ursula Sonnewald