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Hormone Receptors in Breast Cancer, Suzanne A. W. Fuqua


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Цена: 23757.00р.
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Автор: Suzanne A. W. Fuqua
Название:  Hormone Receptors in Breast Cancer
ISBN: 9781489996800
Издательство: Springer
Классификация:



ISBN-10: 148999680X
Обложка/Формат: Paperback
Страницы: 281
Вес: 0.45 кг.
Дата издания: 2008
Серия: Cancer Treatment and Research
Язык: English
Издание: 2009 ed.
Иллюстрации: Biography
Размер: 234 x 156 x 16
Читательская аудитория: Professional & vocational
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Германии
Описание: Hormone Receptors in Breast Cancer provides an up-to-date resource of the role of hormone receptors in breast cancer written in depth for both the basic molecular academic researcher and translational scientist. Advances in basic science of molecular endocrinology have undoubtedly been translated into clinical practice, and clinicians caring for this disease need to be knowledgeable about these developments. The molecular basis of hormone action has been elucidated, and the relative significance of the different estrogen and progesterone receptor isoforms has been explored. This explosion of information has lead to exciting new areas of gene specific targeting of the disease, and breast cancer prevention. Paradigm shifts in treatment options and sequencing have recently occurred in breast cancer management, necessitating close cooperation and communication between translational scientists and physicians. This book is focused on providing this communication.
Дополнительное описание: Hormone Action and Clinical Significance of the Estrogen Receptor #x03B1;.- Role of ER#x03B2; in Clinical Breast Cancer.- Hormone Action and Breast Cancer.- Estrogen Receptors in Breast Tumors of African American Patients.- BRCA1 Cross-Talk with Hormone R



Chemokine Receptors in Cancer

Автор: Amy Fulton
Название: Chemokine Receptors in Cancer
ISBN: 1617378852 ISBN-13(EAN): 9781617378850
Издательство: Springer
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Цена: 26120.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Chemokines are a superfamily of low molecular weight cytokines. In humans, there are approximately 45 chemokines that bind to 19 G-protein-coupled receptors. This book reviews what we do and do not know about the role of chemokine receptors in cancer behavior.

Death Receptors and Cognate Ligands in Cancer

Автор: Holger Kalthoff
Название: Death Receptors and Cognate Ligands in Cancer
ISBN: 3642260764 ISBN-13(EAN): 9783642260766
Издательство: Springer
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Цена: 36197.00 р.
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Описание: Death receptors play a central role in directing apoptosis in mammalian cells. This book explores the molecular basis of death receptor signaling and their role in cancer development.

Discoidin Domain Receptors in Health and Disease

Автор: Fridman
Название: Discoidin Domain Receptors in Health and Disease
ISBN: 1493963813 ISBN-13(EAN): 9781493963812
Издательство: Springer
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Цена: 23508.00 р.
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Описание: The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. A failure to establish these normal interactions and to interpret the cues emanating from the ECM is one of the major causes in abnormal development and the pathogenesis of multiple diseases. To recognize and act upon the biophysical signals that are generated by the cross talk between cells and ECM, the cells developed specific receptors, among them a unique set of receptor tyrosine kinases (RTKs), known as the Discoidin Domain Receptors (DDRs). The DDRs are the only RTKs that specifically bind to and are activated by collagen, a major protein component of the ECM. Hence, the DDRs are part of the signaling networks that translate information from the ECM, and thus they are key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis by acting on collagen sensors; transducing signals that regulate cell polarity, tissue morphogenesis, cell differentiation, and collagen deposition. DDRs play a key role in diseases that are characterized by dysfunction of the stromal component, which lead to abnormal collagen deposition and the resulting fibrotic response that disrupt normal organ function in disease of the cardiovascular system, lungs and kidneys, just to mention a few. In cancer, DDRs are hijacked by tumor and stromal cells to disrupt normal cell-collagen communication and initiate pro-oncogenic programs. Importantly, several cancer types exhibit DDR mutations, which are thought to alter receptor function, and contribute to cancer progression. Therefore, the strong causative association between altered RTK function and disease it is been translated today in the development of specific tyrosine kinase inhibitors targeting DDRs for various disease conditions. In spite of the accumulating evidence highlighting the importance of DDRs in health and diseases, there is still much to learn about these unique RTKs, as of today there is a lack in the medical literature of a book dedicated solely to DDRs. This is the first comprehensive volume dedicated to DDRs, which will fill a gap in the field and serve those interested in the scientific community to learn more about these important receptors in health and disease.

Nuclear Receptors

Автор: Chris M. Bunce; Moray J. Campbell
Название: Nuclear Receptors
ISBN: 9400731736 ISBN-13(EAN): 9789400731738
Издательство: Springer
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Цена: 28732.00 р.
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Описание: Featuring contributions from authors of major standing in the field, this book presents up to dat reviews of diverse aspects of nuclear receptor biology. It provides an outstanding reference book for new and established nuclear receptor researchers.

Hormones: A Very Short Introduction

Автор: Luck Martin
Название: Hormones: A Very Short Introduction
ISBN: 0199672873 ISBN-13(EAN): 9780199672875
Издательство: Oxford Education
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Цена: от 1138.00 р.
Наличие на складе: Есть

Описание: Hormones are vital to the workings of the body, and while many people are aware of what hormones do, few have an appreciation of the nature and importance of the endocrine system. In this Very Short Introduction, Martin Luck explains what hormones are, what they do, where they come from, and how they work.

Nuclear Receptors

Автор: Chris M. Bunce; Moray J. Campbell
Название: Nuclear Receptors
ISBN: 9048133025 ISBN-13(EAN): 9789048133024
Издательство: Springer
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Цена: 28734.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Featuring contributions from authors of major standing in the field, this book presents up to dat reviews of diverse aspects of nuclear receptor biology. It provides an outstanding reference book for new and established nuclear receptor researchers.

Hormone Therapy

Автор: Sherif Katherine
Название: Hormone Therapy
ISBN: 1461462673 ISBN-13(EAN): 9781461462675
Издательство: Springer
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Цена: 15372.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Hormone Therapy: A Clinical Handbook provides a comprehensive overview on hormone replacement therapy, with a range of key features that differentiate it from other titles on the topic.


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