Автор: Oystein Bruserud Название: The Chemokine System in Experimental and Clinical Hematology ISBN: 3642264654 ISBN-13(EAN): 9783642264658 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This comprehensive explanation of the importance of the chemokine system in hematology focuses on the development of hematologic malignancies, including the immunobiology of stem cell transplantation. It shows that chemokines can be involved in leukemogenesis.
Автор: Fridman Название: Discoidin Domain Receptors in Health and Disease ISBN: 1493963813 ISBN-13(EAN): 9781493963812 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. A failure to establish these normal interactions and to interpret the cues emanating from the ECM is one of the major causes in abnormal development and the pathogenesis of multiple diseases. To recognize and act upon the biophysical signals that are generated by the cross talk between cells and ECM, the cells developed specific receptors, among them a unique set of receptor tyrosine kinases (RTKs), known as the Discoidin Domain Receptors (DDRs). The DDRs are the only RTKs that specifically bind to and are activated by collagen, a major protein component of the ECM. Hence, the DDRs are part of the signaling networks that translate information from the ECM, and thus they are key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis by acting on collagen sensors; transducing signals that regulate cell polarity, tissue morphogenesis, cell differentiation, and collagen deposition. DDRs play a key role in diseases that are characterized by dysfunction of the stromal component, which lead to abnormal collagen deposition and the resulting fibrotic response that disrupt normal organ function in disease of the cardiovascular system, lungs and kidneys, just to mention a few. In cancer, DDRs are hijacked by tumor and stromal cells to disrupt normal cell-collagen communication and initiate pro-oncogenic programs. Importantly, several cancer types exhibit DDR mutations, which are thought to alter receptor function, and contribute to cancer progression. Therefore, the strong causative association between altered RTK function and disease it is been translated today in the development of specific tyrosine kinase inhibitors targeting DDRs for various disease conditions. In spite of the accumulating evidence highlighting the importance of DDRs in health and diseases, there is still much to learn about these unique RTKs, as of today there is a lack in the medical literature of a book dedicated solely to DDRs. This is the first comprehensive volume dedicated to DDRs, which will fill a gap in the field and serve those interested in the scientific community to learn more about these important receptors in health and disease.
Автор: Suzanne A. W. Fuqua Название: Hormone Receptors in Breast Cancer ISBN: 148999680X ISBN-13(EAN): 9781489996800 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Hormone Receptors in Breast Cancer provides an up-to-date resource of the role of hormone receptors in breast cancer written in depth for both the basic molecular academic researcher and translational scientist. Advances in basic science of molecular endocrinology have undoubtedly been translated into clinical practice, and clinicians caring for this disease need to be knowledgeable about these developments. The molecular basis of hormone action has been elucidated, and the relative significance of the different estrogen and progesterone receptor isoforms has been explored. This explosion of information has lead to exciting new areas of gene specific targeting of the disease, and breast cancer prevention. Paradigm shifts in treatment options and sequencing have recently occurred in breast cancer management, necessitating close cooperation and communication between translational scientists and physicians. This book is focused on providing this communication.
Автор: Holger Kalthoff Название: Death Receptors and Cognate Ligands in Cancer ISBN: 3642260764 ISBN-13(EAN): 9783642260766 Издательство: Springer Рейтинг: Цена: 36197.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Death receptors play a central role in directing apoptosis in mammalian cells. This book explores the molecular basis of death receptor signaling and their role in cancer development.
Автор: Chris M. Bunce; Moray J. Campbell Название: Nuclear Receptors ISBN: 9400731736 ISBN-13(EAN): 9789400731738 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Featuring contributions from authors of major standing in the field, this book presents up to dat reviews of diverse aspects of nuclear receptor biology. It provides an outstanding reference book for new and established nuclear receptor researchers.
Автор: Chris M. Bunce; Moray J. Campbell Название: Nuclear Receptors ISBN: 9048133025 ISBN-13(EAN): 9789048133024 Издательство: Springer Рейтинг: Цена: 28734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Featuring contributions from authors of major standing in the field, this book presents up to dat reviews of diverse aspects of nuclear receptor biology. It provides an outstanding reference book for new and established nuclear receptor researchers.
ООО "Логосфера " Тел:+7(495) 980-12-10 www.logobook.ru
