Phosphoinositide 3-kinase in Health and Disease, Christian Rommel; Bart Vanhaesebroeck; Peter K. Vo

Автор: Mario D. Cordero; Benoit Viollet
Название: AMP-activated Protein Kinase
ISBN: 3319435876 ISBN-13(EAN): 9783319435879
Издательство: Springer
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Цена: 30745.00 р.
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Описание: AMPK has emerged as an important integrator of signals that control energy balance through the regulation of multiple biochemical pathways in eukaryotes. This book focuses on the implications of AMPK as a master metabolic regulator in diseases, including new methods and animal models. The contributions are written by leading experts in the field and give an extensive overview of the current knowledge of AMPK biology and the role of AMPK in health and disease. 

Автор: Christian Rommel; Bart Vanhaesebroeck; Peter K. Vo
Название: Phosphoinositide 3-kinase in Health and Disease
ISBN: 3642265308 ISBN-13(EAN): 9783642265303
Издательство: Springer
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Цена: 28732.00 р.
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Описание: PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis. This book details key discoveries in the area, their impact and future directions.

Автор: Ingo K. Mellinghoff; Charles L. Sawyers
Название: Therapeutic Kinase Inhibitors
ISBN: 3642445802 ISBN-13(EAN): 9783642445804
Издательство: Springer
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Цена: 26120.00 р.
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Описание:

Cancer drug development is currently undergoing a profound shift. Drugs targeting fundamental cellular processes such DNA-replication and microtubule function, often referred to as chemotherapy and still the backbone of most cancer treatment regimens, are increasingly being complemented by or replaced with kinase inhibitors. This new class of drugs targets enzymes which provide growth and survival signals to cancer cells by transferring phosphate groups from Adenosine-5'-triphosphate (ATP) to other proteins, lipids, nucleotides, and carbohydrates.

This book summarizes the current state of kinase inhibitor therapy for cancer. Successful drug development relies on the expertise and dedication of many experts. To reflect this team approach to finding new kinase inhibitors and defining their optimal use for cancer treatment, the editorsinvited experts in academia and pharmaceutical industry to share their insights into various aspects of this process, ranging from the first chemical screens, to preclinical testing and disease-focused clinical drug development. The editors and authorshope these lessons will be instructive for the novice as well as the expert. "

Автор: Anthony Koleske
Название: Abl Family Kinases in Development and Disease
ISBN: 1489995536 ISBN-13(EAN): 9781489995537
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Abl Family Kinases in Development and Disease provides an overview of the functions of Abl family kinases in Development and Disease. This new title discusses the biochemical, genetic, and cell biological data that elucidate the cellular roles for these kinases in these processes.

Автор: Salomons
Название: Creatine and Creatine Kinase in Health and Disease
ISBN: 9048176522 ISBN-13(EAN): 9789048176526
Издательство: Springer
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Цена: 32144.00 р.
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Описание: This volume places emphasis on the intricate interplay between creatine and creatine kinase function on one hand and proper brain function, neurodegenerative disease and/or neuroprotection on the other. The book, compiled by outstanding experts, provides a key reference summarizing the state-of-the-art in creatine and creatine kinase research.

Автор: Marcelo G. Kazanietz
Название: Protein Kinase C in Cancer Signaling and Therapy
ISBN: 1617796913 ISBN-13(EAN): 9781617796913
Издательство: Springer
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Цена: 41787.00 р.
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Описание: Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980`s with its identification as an effector of phorbol esters, natural products with tumor promoting activity.

Автор: Daniele Focosi
Название: Resistance to Tyrosine Kinase Inhibitors
ISBN: 3319460900 ISBN-13(EAN): 9783319460901
Издательство: Springer
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Цена: 23508.00 р.
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Описание: The volume will serve as a primer on tyrosine kinase signaling and its importance in cancer. The volume will first introduce the common denominators of small-molecule and antibody-derived inhibitors, as well as the general phenomenon of resistance. The volume will then detail resistance to the most commonly used classes of tyrosine kinase inhibitors, and will focus specific chapters on resistance to BCR-ABL1, FLT3, angiokinase family members, and ALK inhibitors.