Negative Co-Receptors and Ligands, Rafi Ahmed; Tasuku Honjo

Автор: Michael P. Cancro
Название: BLyS Ligands and Receptors
ISBN: 1617796514 ISBN-13(EAN): 9781617796517
Издательство: Springer
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Цена: 28732.00 р.
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Описание: This volume covers both the basic and translational/clinical aspects of this molecular family, focusing on its role in the differentiation, selection, and regulation of primary and antigen-experienced B cells. In addition, clinical aspects are detailed.

Автор: Holger Kalthoff
Название: Death Receptors and Cognate Ligands in Cancer
ISBN: 3642260764 ISBN-13(EAN): 9783642260766
Издательство: Springer
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Цена: 36197.00 р.
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Описание: Death receptors play a central role in directing apoptosis in mammalian cells. This book explores the molecular basis of death receptor signaling and their role in cancer development.

Автор: Rast
Название: Immune Receptors
ISBN: 1617791385 ISBN-13(EAN): 9781617791383
Издательство: Springer
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Цена: 20263.00 р.
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Описание: Immunology has made significant progress in the past decade, driven forward by rapidly advancing technology and a renewed interest in the vast realm of innate immunity. The receptors that mediate these functions are at the front lines of both protective and regulative roles of the immune system.  In Immune Receptors: Methods and Protocols, expert researchers present a variety of experimental approaches to the characterization of immune receptors and the cell biology that mediates their functions.  These include imaging techniques that aim to understand receptor localization and trafficking, techniques to measure receptor-ligand interactions, strategies to identify novel ligands and methods to analyze downstream receptor signaling, as well as strategies for genomic and proteomic characterization of receptor repertoires. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Immune Receptors: Methods and Protocols offers technical descriptions and protocols that will be useful both to investigators who are interested in carrying out these procedures and to those who seek a deeper understanding of the bench science that lies behind the immunology literature.

Автор: Vivier Eric, Colonna Marco
Название: Immunobiology of Natural Killer Cell Receptors
ISBN: 3540260838 ISBN-13(EAN): 9783540260837
Издательство: Springer
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Цена: 26122.00 р.
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Описание: Natural Killer (NK) cells are large granular lymphocytes of the innate immune system. They are widespread throughout the body, being present in both lymphoid organs and non-lymphoid peripheral tissues. NK cells are involved in direct innate immune reactions against viruses, bacteria, parasites and other triggers of pathology, such as malignant transformation, all of which cause stress in affected cells. Importantly, NK cells also link the innate and adaptive immune responses, contributing to the initiation of adaptive immune responses and executing adaptive responses using the CD16 FcgRIIIA immunoglobulin Fc receptor. Such responses are mediated through two major effector functions, the direct cytolysis of target cells and the production of cytokines and chemokines. The authors focus here on the nature of recognition events by NK cells and address how these events are integrated to trigger these distinct and graded effector functions.

Автор: Zhou
Название: Privileged Chiral Ligands and Catalysts
ISBN: 3527327045 ISBN-13(EAN): 9783527327041
Издательство: Wiley
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Цена: 23118.00 р.
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Описание: * This book is an ultimate "must have" and long awaited reference for every chemist working in the field of asymmetric catalysis * It presents the topic starting from the core structure of the catalysts and explains WHY a certain ligand/catalyst is so successful.

Автор: Patricia H. Reggio
Название: The Cannabinoid Receptors
ISBN: 1617377341 ISBN-13(EAN): 9781617377341
Издательство: Springer
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Цена: 26120.00 р.
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Описание: Here, experts introduce the field with chapters covering, among other subjects, cannabinoid ligand synthesis and structure activity relationships, the molecular pharmacology of cannabinoid receptors, and the therapeutic applications for cannabinoid drugs.

Автор: Olivier Civelli; Qun-Yong Zhou
Название: Orphan G Protein-Coupled Receptors and Novel Neuropeptides
ISBN: 3642097057 ISBN-13(EAN): 9783642097058
Издательство: Springer
Цена: 36197.00 р.
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Описание: The Orphanin FQ/Nociceptin (OFQ/N) System.- Orexins and Orexin Receptors: From Molecules to Integrative Physiology.- Prolactin-Releasing Peptide.- Structure and Function of Ghrelin.- GPR54 and Kisspeptins.- Neuropeptide S: Anatomy, Pharmacology, Genetics and Physiological Functions.- The Melanin-Concentrating Hormone System and Its Physiological Functions.- Biological Function of Prokineticins.- Neuromedin S: Discovery and Functions.- Relaxin-3, INSL5, and Their Receptors.- The NPB/NPW Neuropeptide System and Its Role in Regulating Energy Homeostasis, Pain, and Emotion.

Автор: Salvatore J. Enna; Hanns M?hler
Название: The GABA Receptors
ISBN: 1627038957 ISBN-13(EAN): 9781627038959
Издательство: Springer
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Цена: 28732.00 р.
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Описание: The Gaba Receptors, Third Edition, presents a critical appraisal of our current understanding of the molecular, behavioral, biochemical, clinical, and pharmacological properties of GABA receptors.

Автор: Bryan L. Roth
Название: The Serotonin Receptors
ISBN: 1617376477 ISBN-13(EAN): 9781617376474
Издательство: Springer
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Цена: 36570.00 р.
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Описание: Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.