Pharmaceutical analysis forms a core part of any pharmacy programme, as well as being essential for pharmacology and medicinal chemistry courses.
Pharmaceutical analysis determines the purity, concentration, active compounds, shelf life, rate of absorption in the body, identity, stability, rate of release etc. of a drug. Testing a pharmaceutical product involves a variety of analyses, and the analytical processes described in this book are used in industries as diverse as food, beverages, cosmetics, detergents, metals, paints, water, agrochemicals, biotechnological products and pharmaceuticals.
The mathematics involved is notoriously difficult, but this much-praised textbook, now revised and updated for its fourth edition, guides a student through the complexities with clear writing and the author's expertise from many years' teaching pharmacy students. There is continuous learning reinforcement throughout the book by way of worked calculation examples and self-assessment test questions.
Worked calculation examples
Additional problems (self tests)
Key points boxes
New chapter on electrochemical biosensors.
New chapter on the quality control of biotechnologically produced drugs.
Extended chapter on molecular emission spectroscopy.
Now comes with an e-book on StudentConsult.
Self-assessment is interactive in the accompanying online e-book.
65 online animations show concepts such as ionization partitioning of drug molecules etc.
Автор: Kilcoyne Daniel Название: Pharmaceutical Medicine ISBN: 0199609144 ISBN-13(EAN): 9780199609147 Издательство: Oxford Academ Рейтинг: Цена: 4839 р. Наличие на складе: Есть (1 шт.) Описание: Pharmaceutical Medicine provides an accessible, user-friendly and up-to-date guide for those involved in clinical trials or marketing of new medicines in the pharmaceutical industry.
Автор: David G. Watson Название: Pharmaceutical Analysis, ISBN: 0702046213 ISBN-13(EAN): 9780702046216 Издательство: Elsevier Science Цена: 4394 р. Наличие на складе: Невозможна поставка.
Описание: A user-friendly guide for the evaluation of microbiological assays, Microbiological Assay for Pharmaceutical Analysis: A Rational Approach provides a lucid explanation of the sources of error in microbiological assay and helps analysts choose efficient assay designs that will minimize those sources of error. Beginning with a review of the theoretical basis for the quantitative aspects, the author discusses microbiological assay as a branch of pharmaceutical analysis and distinguishes it from biological assay in general. He draws attention to the microbiological aspects that may not be so obvious to the chemical analyst and to the analytical aspects that may not be so obvious to the microologist. The book contains detailed evaluations of assays that illustrate typical experimental designs and addresses how to present a realistic assessment of the best potency estimate from a series of assays. Although there are other valuable books available in this area, they do not address evaluation. Microbiological Assay for Pharmaceutical Analysis: A Rational Approach expands on the guidance given in pharmacopoeias and helps you choose the assay design most appropriate for the purpose of your
Автор: Hsiao Название: Design and Analysis of Bridging Studies ISBN: 1439846340 ISBN-13(EAN): 9781439846346 Издательство: Taylor&Francis Рейтинг: Цена: 9090 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: As the development of medicines has become more globalized, the geographic variations in the efficacy and safety of pharmaceutical products need to be addressed. To accelerate the product development process and shorten approval time, researchers are beginning to design multiregional trials that incorporate subjects from many countries around the world under the same protocol. Design and Analysis of Bridging Studies addresses the issues arising from bridging studies and multiregional clinical trials. For bridging studies, the book explores ethnic sensitivity, the necessity of bridging studies, types of bridging studies, and the assessment of similarity between regions based on bridging evidence. For multiregional clinical trials, the text considers regional differences, assesses the consistency of treatment effect across regions, and discusses sample size determination for each region. Taking into account the International Conference Harmonisation (ICH) E5 framework for bridging studies, the book provides a unified summary of the growing literature and research activities in this area. It covers the regulatory requirements, scientific and practical issues, and statistical methodology for designing and evaluating bridging studies and multiregional clinical trials, with the goal of inspiring new research activities in the field.
Описание: Clinical trials often include the evaluation of Health-Related Quality of Life (HRQoL), yet many investigators remain unaware of the unique measurement and analysis issues associated with the assessment of HRQoL. Focusing on the specific features of QoL data, this book details the relevant issues and presents a range of solutions. Written from the author's extensive experience in the field, it includes SAS and S-PLUS programs, checklists, figures, and a clear presentation that combine to provide readers with the tools and skills they need to design, conduct, analyze, and report their own studies.
Автор: Iwona Wawer Название: NMR Spectroscopy in Pharmaceutical Analysis, ISBN: 0444531734 ISBN-13(EAN): 9780444531735 Издательство: Elsevier Science Рейтинг: Цена: 9345 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling and assay, qNMR can be utilized. Separation techniques such as high performance liquid chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve the analytical problems often resulting in insufficient methods. Nevertheless such methods find their way into international pharmacopoeias. Thus, the aim of the book is to describe the possibilities of qNMR in pharmaceutical analysis. Beside the introduction to the physical fundamentals and techniques the principles of the application in drug analysis are described: quality evaluation of drugs, polymer characterization, natural products and corresponding reference compounds, metabolism, and solid phase NMR spectroscopy for the characterization drug substances, e.g. the water content, polymorphism, and drug formulations, e.g. tablets, powders. This part is accompanied by more special chapters dealing with representative examples. They give more detailed information by means of concrete examples.
Описание: The most commonly used method for analyzing substances, and the first method most researchers turn to, is high performance liquid chromatography (HPLC). Following up on a best-seller, volumes 2-4 continue to provide an easily-accessible collection of procedures for analyzing pharmaceuticals using HPLC.
Описание: The "HPLC Methods for Pharmaceutical Analysis" series allowed researchers to develop HPLC methods and analyze the most popular pharmaceutical compounds without the time and effort associated with intensive literature searches. This hardback/CD-ROM set brings together volumes 1-4 of the series, and contains the additional 8000 abstracts covering 1100 pharmaceuticals from volumes 2-4. Organized by compound, this reference provides summaries of analytical methods developed for each drug in sufficient detail so that these methods can be replicated without reference to the original. Since detailed procedures are listed together for each compound, the analyst can evaluate and combine features of different methods to create customized procedures. In addition, the complete library of analytical methods contained in all four volumes of "HPLC Methods for Pharmaceutical Analysis", plus the contents of "Capillary Electrophoresis Methods for Pharmaceutical Analysis", are included. Other features are: basic information for each compound, including compound name, molecular weight, molecular formula, CAS number and Merck index number, and complex search capabilities as well as substructure searching capabilities.
Описание: Handbook of Modern Pharmaceutical Analysis, Second Edition, synthesizes the complex research and recent changes in the field, while covering the techniques and technology required for today's laboratories. The work integrates strategy, case studies, methodologies, and implications of new regulatory structures, providing complete coverage of quality assurance from the point of discovery to the point of use.
Treats pharmaceutical analysis (PA) as an integral partner to the drug development process rather than as a service to it
Covers method development, validation, selection, testing, modeling, and simulation studies combined with advanced exploration of assays, impurity testing, biomolecules, and chiral separations
Features detailed coverage of QA, ethics, and regulatory guidance (quality by design, good manufacturing practice), as well as high-tech methodologies and technologies from "lab-on-a-chip" to LC-MS, LC-NMR, and LC-NMR-MS
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