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PI3K-mTOR in Cancer and Cancer Therapy, Dey


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Цена: 23508.00р.
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Автор: Dey
Название:  PI3K-mTOR in Cancer and Cancer Therapy
ISBN: 9783319342092
Издательство: Springer
Классификация:




ISBN-10: 3319342096
Обложка/Формат: Hardback
Страницы: 294
Вес: 0.64 кг.
Дата издания: 2016
Серия: Cancer Drug Discovery and Development
Язык: English
Иллюстрации: 31 colour illustrations, 28 colour tables, biography
Размер: 234 x 156 x 19
Читательская аудитория: General (us: trade)
Основная тема: Biomedicine
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: In the post human-genome project era, cancer specific genomic maps are redesigning tumor taxonomy by evolving from histopathology to molecular pathology. The success of a cancer drug today is fundamentally based on the success in identifying target genes that control beneficial pathways. The overwhelming power of genomics and proteomics has enlightened researchers about the fact that the PI3K-mTOR pathway is the most commonly up-regulated signal transduction pathway in various cancers, either by virtue of its activation downstream of many cell surface growth factor receptors or by virtue of its collateral and compensatory circuitry with RAS-MAPK pathway. Oncogenic signaling in the majority of solid tumors is sustained via the PI3K-AKT-mTOR pathway. Because of its prominent role in many cancer types, the PI3K-mTOR pathway has become a major therapeutic target. The volume includes two complementary parts which address the problem of etiology and disease progression and is intended to portray the very basic mechanisms of the PI3K-AKT-mTOR signaling pathway’s involvement in various facets of the cancer, including stem cell renewal, cell metabolism, angiogenesis, genetic instability, and drug resistance. Significant progress has been made in recent years elucidating the molecular mechanism of cancer cell proliferation, angiogenesis, and drug-resistance in relation to the PI3K-mTOR pathway and this volume provides an in-depth overview of recent developments made in this area.?
Дополнительное описание: PI3K-Akt-mTOR Signaling in Cancer and Cancer Therapeutics.- Part 1: PI3K-mTOR Pathway in Cancers.- The mTOR Complexes in Cancer Cell Metabolism.- PI3K-AKT-mTOR Pathway Co-operates with the DNA Damage Repair Pathway: Carcinogenesis in Triple Negative Breas



The Molecular Biology of Cancer, 2nd Edition

Автор: Pelengaris
Название: The Molecular Biology of Cancer, 2nd Edition
ISBN: 1118008812 ISBN-13(EAN): 9781118008812
Издательство: Wiley
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Цена: 10306.00 р. 14723.00 -30%
Наличие на складе: Есть (1 шт.)
Описание: The Molecular Biology of Cancer, Stella Pelengaris & Michael Khan This capturing, comprehensive text, extensively revised and updated for its second edition, provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment.

Microspheres and Regional Cancer Therapy

Автор: Willmott
Название: Microspheres and Regional Cancer Therapy
ISBN: 0849369525 ISBN-13(EAN): 9780849369520
Издательство: Taylor&Francis
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Цена: 53592.00 р.
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Описание: Microspheres and Regional Cancer Therapy takes an interdisciplinary approach to the subject of microspheres and regional cancer therapy

Epigenetic Cancer Therapy

Автор: Steven Gray
Название: Epigenetic Cancer Therapy
ISBN: 0128002069 ISBN-13(EAN): 9780128002063
Издательство: Elsevier Science
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Цена: 17517.00 р.
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Описание:

Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector.

The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver).

The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer.

DNA Repair in Cancer Therapy

Автор: Kelley, Mark R.
Название: DNA Repair in Cancer Therapy
ISBN: 012803582X ISBN-13(EAN): 9780128035825
Издательство: Elsevier Science
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Цена: 18696.00 р.
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Описание:

DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment.

Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs.

Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors.

Transforming Growth Factor-Beta in Cancer Therapy, Volume II

Автор: C.-H. Heldin; Sonia B. Jakowlew
Название: Transforming Growth Factor-Beta in Cancer Therapy, Volume II
ISBN: 1617377368 ISBN-13(EAN): 9781617377365
Издательство: Springer
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Цена: 38992.00 р.
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Описание: Transforming Growth Factor- ss in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ss (TGF- ss) in cancer treatment and therapy. The companion volume details the role of TGF- ss on basic and clinical biology.

Transforming Growth Factor-Beta in Cancer Therapy, Volume I

Автор: M.B. Sporn; Sonia B. Jakowlew
Название: Transforming Growth Factor-Beta in Cancer Therapy, Volume I
ISBN: 161737735X ISBN-13(EAN): 9781617377358
Издательство: Springer
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Цена: 36197.00 р.
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Описание: Transforming Growth Factor- ss in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ss (TGF- ss) in cancer treatment and therapy.

mTOR Pathway and mTOR Inhibitors in Cancer Therapy

Автор: Vitaly A. Polunovsky; Peter J. Houghton
Название: mTOR Pathway and mTOR Inhibitors in Cancer Therapy
ISBN: 1617796948 ISBN-13(EAN): 9781617796944
Издательство: Springer
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Цена: 28732.00 р.
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Описание: The target of rapamycin (TOR) was rst identi ed in Saccharomyces cerevisiae and subsequently in mammals (mTOR) as a conserved atypical serine/threonine kinase. Rapamycin was isolated as a product of the soil bacteria Streptomyces hygroscopicus, identi ed in a soil sample taken from the island of Rapa Nui (Easter Island).

Drug Delivery Systems In Cancer Therapy

Автор: Brown, Dennis M.
Название: Drug Delivery Systems In Cancer Therapy
ISBN: 0896038882 ISBN-13(EAN): 9780896038882
Издательство: Springer
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Цена: 30039.00 р.
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Описание: Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. In their outline and discussion of the use of novel formulation technologies-including synthetic polymers and biomaterials for prolonged or sustained drug release to achieve potentially greater therapeutic effect-they profile those technologies that have resulted in a number of approved and late-stage clinical products.

Gene Therapy of Cancer,

Автор: Edmund C. Lattime
Название: Gene Therapy of Cancer,
ISBN: 0123942950 ISBN-13(EAN): 9780123942951
Издательство: Elsevier Science
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Цена: 23244.00 р.
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Описание: Gene therapy as a treatment for cancer is at a critical point in its evolution. This book offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells.


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