Analysis of genetic association studies, Zheng, Gang Yang, Yaning Zhu, Xiaofeng Elston, Robert C.
Автор: Cedric Gondro; Julius van der Werf; Ben Hayes Название: Genome-Wide Association Studies and Genomic Prediction ISBN: 1493959646 ISBN-13(EAN): 9781493959648 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Methods in Molecular Biology (TM) book covers phenotypes of interest as well as design issues for GWAS, methods for storing and handling large datasets, quality control measures, haplotype inference, and imputation and statistical approaches to data analysis.
Описание: Genetic Association Studies is designed for students of public health, epidemiology, and the health sciences, covering the main principles of molecular genetics, population genetics, medical genetics, epidemiology and statistics. It presents a balanced view of genetic associations with coverage of candidate gene studies as well as genome-wide association studies. All aspects of a genetic association study are included, from the lab to analysis and interpretation of results, but also bioinformatics approaches to causality assessment. The role of the environment in genetic disease is also highlighted. Genetic Association Studies will enable readers to understand and critique genetic association studies and set them on the way to designing, executing, analyzing, interpreting, and reporting their own.
Описание: This book presents the statistical aspects of designing, analyzing and interpreting the results of genome-wide association scans (GWAS studies) for genetic causes of disease using unrelated subjects. Particular detail is given to the practical aspects of employing the bioinformatics and data handling methods necessary to prepare data for statistical analysis. The goal in writing this book is to give statisticians, epidemiologists, and students in these fields the tools to design a powerful genome-wide study based on current technology. The other part of this is showing readers how to conduct analysis of the created study. Design and Analysis of Genome-Wide Association Studies provides a compendium of well-established statistical methods based upon single SNP associations. It also provides an introduction to more advanced statistical methods and issues. Knowing that technology, for instance large scale SNP arrays, is quickly changing, this text has significant lessons for future use with sequencing data. Emphasis on statistical concepts that apply to the problem of finding disease associations irrespective of the technology ensures its future applications. The author includes current bioinformatics tools while outlining the tools that will be required for use with extensive databases from future large scale sequencing projects. The author includes current bioinformatics tools while outlining additional issues and needs arising from the extensive databases from future large scale sequencing projects.
Описание: Design, Analysis, and Interpretation of Genome-Wide Association Scans
Название: Genome-wide association studies and genomic prediction ISBN: 1627034463 ISBN-13(EAN): 9781627034463 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Methods in Molecular Biology(TM) book covers phenotypes of interest as well as design issues for GWAS, methods for storing and handling large datasets, quality control measures, haplotype inference, and imputation and statistical approaches to data analysis.
Автор: Griffiths Название: Modern Genetic Analysis.2002.2ed.+CD ISBN: 0716743825 ISBN-13(EAN): 9780716743828 Издательство: Freeman Цена: 5520.00 р. Наличие на складе: Нет в наличии.
Описание: This text implements an innovative approach to teaching genetics. Rather than presenting material in historical order, the text integrates molecular genetics with classical genetics. The integrated approach provides students with a concrete foundation in molecules, while simultaneously building an understanding of the more abstract elements of transmission genetics. The book also incorporates greater attention to pedagogy, improved chapter organization, enhanced art, and a better overall design, making it a more effective learning tool.
Описание: The volume presents a broad spectrum of papers presented at the Workshop, and thus illustrates the range of current research related to the theory, methods and applications of HRQoL, as well as the interdisciplinary nature ofthis work.
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