Описание: Characterization of Liquids, Dispersions, Emulsions and Porous Materials Using Ultrasound, Third Edition, presents a scientific background for novel methods of characterizing homogeneous and heterogeneous liquids (dispersions, emulsions, and gels) as well as porous materials. Homogeneous liquids are characterized in rheological terms, whereas particle-size distribution and zeta potential are parameters of heterogeneous liquids. For porous materials, porosity, pore size, and zeta potential are output characteristics. These methods are based on ultrasound, which opens an opportunity for simplifying the sample preparation by eliminating dilution. This in turn, makes measurements faster, easier, precise, suitable for accurate quality control, PAT, and formulation of complex systems. . This book provides theoretical background of acoustics, rheology, colloid science, electrochemistry, and other relevant scientific fields, describing principles of existing instrumentation and, in particular, commercially available instruments. Finally, the book features an extensive list of existing applications. .
Presents Practical Applications of Mass Spectrometry for Protein Analysis and Covers Their Impact on Accelerating Drug Discovery and Development
Covers both qualitative and quantitative aspects of Mass Spectrometry protein analysis in drug discovery
Principles, Instrumentation, Technologies topics include MS of peptides, proteins, and ADCs, instrumentation in protein analysis, nanospray technology in MS protein analysis, and automation in MS protein analysis
Details emerging areas from drug monitoring to patient care such as Identification and validation of biomarkers for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives
Brings together the most current advances in the mass spectrometry technology and related method in protein analysis
Автор: Gross, Jurgen H. Название: Mass spectrometry ISBN: 3319543970 ISBN-13(EAN): 9783319543970 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Поставка под заказ.
Описание: Covering the fundamentals of ion chemistry, design of analyzers and interpretation techniques, this textbook is expanded with three new chapters on tandem mass spectrometry, interfaces for sampling at atmospheric pressure, and inorganic mass spectrometry.
Автор: Rodney Pearlman; Y. John Wang Название: Stability and Characterization of Protein and Peptide Drugs ISBN: 148991238X ISBN-13(EAN): 9781489912381 Издательство: Springer Рейтинг: Цена: 28734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: John R. Chapman Название: Protein and Peptide Analysis by Mass Spectrometry ISBN: 1489940731 ISBN-13(EAN): 9781489940735 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The purpose of the preface is to explain the book's objectives and how to use it; give warnings, disclaimers, and the like.* The main objective of Protein and Peptide Analysis by Mass Spec trometry is quite straightforward—to present authoritative, up-to-date, and practical accounts of the use of mass spectrometry in the analysis of pep tides and proteins. How to use it? Every reader will have their own particular interests and will surely be drawn toward the chapters that cover these interests. Within the remaining chapters, however, techniques are described with analytical possibilities that such a reader can then only guess at. So, read the book fully. Again, as is customary in the Methods in Molecular Biology series, the chapter format (Introduction, Materials, Methods, and Notes) allows the authors to introduce the techniques, to explain their relevance and applicability, and, above all, to provide detail—detail that represents each author's accumulated experience and enables the reader to use and benefit from these methods. So, read the book fully, and read it diligently. Warnings and disclaimers: Mass spectrometry today offers the pro tein chemist ready access to a wealth of information that is otherwise avail able only with great difficulty, or perhaps not at all. With this goal in sight, any warnings and disclaimers will almost surely be ignored. So, a warning anyway; the use of mass spectrometry might be habit forming.
Preface. Complex Biologics: Engineering the Tools and the Hosts.M. Cristina Vega, Francisco J. Fernбndez and Imre Berger
Section 1: Introduction
1. Protein complex production from the drug discovery standpoint; Ismail Moarefi
Choose a suitable expression host: a survey of available protein production platforms; Francisco J. Fernбndez and M. Cristina Vega
Section 2: Prokaryotic expression hosts
3.ACEMBL Tool-Kits for High-Throughput Multigene Delivery and Expression in Prokaryotic and Eukaryotic Hosts; Yan Nie, Maxime Chaillet, Christian Becke, Matthias Haffke, Martin Pelosse, Daniel Fitzgerald, Ian Collinson, Christiane Schaffitzel and Imre Berger
4.Complex reconstitution and characterization by combining co-expression techniques in Escherichia coli with high-throughput; Renaud Vincentelli and Christoph Romier
5.Membrane protein production in E. coli for applications in drug discovery; Harm Jan (Arjan) Snijder and Jonna Hakulinen
6.Cell-free Synthesis of Macromolecular Complexes; Matthieu Botte, Aurйlien Deniaud and Christiane Schaffitzel
7.A Bacillus megaterium system for the production of recombinant proteins and protein complexes; Rebekka Biedendieck
8.Protein complex production in alternative prokaryotic hosts; Sara Gуmez, Miguel Lуpez-Estepa, Francisco J. Fernбndez and M. Cristina Vega
Section 3: Lower Eukaryotic expression hosts
9.Production of Protein Complexes in Non-methylotrophic and Methylotrophic Yeasts; Francisco J. Fernandez, Miguel Lуpez-Estepa, Javier Querol-Garcнa and M. Cristina Vega
10.Leishmania tarentolae for the Production of Multi-Subunit Complexes; Tomoaki Niimi
11.Alternative Eukaryotic Expression Systems for the Production of Proteins and Protein Complexes; Sara Gуmez, Miguel Lуpez-Estepa, Francisco J. Fernбndez, Teresa Suбrez and M. Cristina Vega
Section 4: Higher Eukaryotic expression hosts
12.Fundamentals of baculovirus expression and applications; Tom A. Kost and Christopher W. Kemp
13.The MultiBac Baculovirus / Insect Cell Expression Vector System for Producing Complex Protein Biologics; Duygu Sari, Kapil Gupta, Deepak Balaji Govinda Raj, Alice Aubert, Petra Dmcova, Frederic Garzoni, Daniel Fitzgerald and Imre Berger
14. Fundamentals of expression in mammalian cells;Michael R. Dyson
15. Assembling multi-subunit complexes using mammalian expression; Bahar Baser and Joop van den Heuvel
Section 5: Plant expression
16.Microalgae as solar-powered protein factories; Franziska Hempel and Uwe G. Maier
17.Strategies and methodologies for the co-expression of multiple proteins in plants; Albert Ferrer, Montserrat Arrу, David Manzano and Teresa Altabella
18. Transient expression systems in plants-potentialities and constraints; Tomas Canto
Описание: This book presents the latest methods and technology used to characterize and discover novel mechanisms of G protein-coupled receptors (GPCRs) which, in many cases, can be used directly to design experiments for the reader`s particular GPCR of interest.
Описание: At present where protein identification and characterisation using mass spectrometry is a method of choice, this book is presenting a review of basic proteomic techniques. The second part of the book is related to the novel high throughput protein identification technique called the `molecular scanner`.
Автор: Jean-Jacques Lacapere Название: Membrane Protein Structure and Function Characterization ISBN: 1493971492 ISBN-13(EAN): 9781493971497 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this present volume, different approaches are detailed to produce membrane proteins, purify them, study their function, determine their structure, and model them in membrane.
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