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Viral proteases and their inhibitors, 


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Название:  Viral proteases and their inhibitors
Перевод названия: Вирусные протеазы и их ингибиторы
ISBN: 9780128097120
Издательство: Elsevier Science
Классификация:

ISBN-10: 0128097124
Обложка/Формат: Paperback
Страницы: 516
Вес: 0.82 кг.
Дата издания: 06.07.2017
Язык: English
Размер: 153 x 229 x 31
Читательская аудитория: Professional & vocational
Ссылка на Издательство: Link
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Поставляется из: Европейский союз
Описание: Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents.


Prostaglandins and their Inhibitors in Clinical Obstetrics and Gynaecology

Автор: M. Bygdeman; G. Berger; L.G. Keith
Название: Prostaglandins and their Inhibitors in Clinical Obstetrics and Gynaecology
ISBN: 9401167362 ISBN-13(EAN): 9789401167369
Издательство: Springer
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Цена: 6986.00 р.
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Inhibitors of Protein Biosynthesis

Автор: D. Vazquez
Название: Inhibitors of Protein Biosynthesis
ISBN: 3642813119 ISBN-13(EAN): 9783642813115
Издательство: Springer
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Цена: 18167.00 р.
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Role of Proteases in the Pathophysiology of Neurodegenerative Diseases

Автор: Abel Lajtha; Naren L. Banik
Название: Role of Proteases in the Pathophysiology of Neurodegenerative Diseases
ISBN: 1441933603 ISBN-13(EAN): 9781441933607
Издательство: Springer
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Цена: 19589.00 р.
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Описание: Researchers seeking problems that offer more hope of success often avoid subjects that seem to be difficult to approach experimentally, or subjects for which experimental results are difficult to interpret.

Serine Proteases and Their Serpin Inhibitors in the Nervous System

Автор: Barry W. Festoff
Название: Serine Proteases and Their Serpin Inhibitors in the Nervous System
ISBN: 1468483595 ISBN-13(EAN): 9781468483598
Издательство: Springer
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Цена: 6986.00 р.
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Описание: Proceedings of a NATO ARW held in Maratea, Italy, July 2-8, 1989

Mitochondrial Inhibitors and Neurodegenerative Disorders

Автор: Paul R. Sanberg; Hitoo Nishino; Cesario V. Borlong
Название: Mitochondrial Inhibitors and Neurodegenerative Disorders
ISBN: 1468498215 ISBN-13(EAN): 9781468498219
Издательство: Springer
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Цена: 20962.00 р.
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Описание: Believed to be the remnants of bacterial infection of eukaryotic cells eons ago, the mitochondrion evolved a symbiotic relationship in which it dutifully served as the efficient source of A TP for cell function.

Matrix Metalloproteinase Inhibitors

Автор: Satya Prakash Gupta
Название: Matrix Metalloproteinase Inhibitors
ISBN: 3034807643 ISBN-13(EAN): 9783034807647
Издательство: Springer
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Цена: 26120.00 р.
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Описание: MMPs are involved in numerous biological processes, fostering tissue degradation resulting in pathologies from osteoarthritis to tumor metastasis. This book focuses on the latest quantitative research into the endogenous inhibitors that disrupt MMP activity.

Modes and Mechanisms of Microbial Growth Inhibitors

Автор: Fred E. Hahn
Название: Modes and Mechanisms of Microbial Growth Inhibitors
ISBN: 3642689485 ISBN-13(EAN): 9783642689482
Издательство: Springer
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Цена: 18167.00 р.
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Описание: Further search for antibiotics has led to increasing frequency of rediscoveries and drasti- cally decreasing frequency of discoveries of new antibiotics.

Inhibitors Tools in Cell Research

Автор: Theodor B?cher; H. Sies
Название: Inhibitors Tools in Cell Research
ISBN: 3540044418 ISBN-13(EAN): 9783540044413
Издательство: Springer
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Цена: 18167.00 р.
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Описание: The scope of the 20th Mosbach Colloquium may be best illustrated by the following notes sent to the speakers when the colloquium was organized. 2) At this colloquium we want to contribute illustrations of the useful application of inhibitors to biological problems.

Biotechnological Applications of Quorum Sensing Inhibitors

Автор: Kalia
Название: Biotechnological Applications of Quorum Sensing Inhibitors
ISBN: 9811090254 ISBN-13(EAN): 9789811090257
Издательство: Springer
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Цена: 20962.00 р.
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Описание: The book describes the various bioactive molecules that can serve as quorum sensing inhibitors to combat deadly bacterial infections, in addition to several synthetic quorum sensing inhibitors.Quorum sensing is the mechanism through which bacteria develop antibiotic resistance.

Proteases in the Brain

Автор: Uwe Lendeckel; Nigel M Hooper
Название: Proteases in the Brain
ISBN: 1441935738 ISBN-13(EAN): 9781441935731
Издательство: Springer
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Цена: 32004.00 р.
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Описание:

In all organs of the body, proteases have critical roles to play both in normal development and functioning and in disease states. The brain is no exception to this, with proteases having emerging roles in synaptic plasticity, memory, neurodegenerative disorders such as Alzheimer's, Parkinson's and prion diseases, ischemia and traumatic brain injury, inflammatory and infectious diseases, and tumor progression. Proteases in the Brain brings together a wide range of topics under this central theme and highlights the large number of proteases involved in these normal and disease processes.

Proteases in the Brain reviews the role and regulation of proteases in, Alzheimer's disease, brain ischemia and traumatic brain injury, human glioma, inflammatory and infectious diseases of the central nervous system, metabolism of the prion protein, modulating synaptic activity, multiple sclerosis, neuronal plasticity and memory consolidation, Parkinson's disease, processing, conversion and inactivation of neuropeptides.

Proteases in the Brain is a timely and useful source of information both for those well-versed in the role of proteases in the brain, and for those who are beginning to realize the important role of this family of enzymes in brain function and dysfunction.

Natural Growth Inhibitors and Phytohormones in Plants and Environment

Автор: V. Kefeli; Bruno Borsari; M.V. Kalevitch
Название: Natural Growth Inhibitors and Phytohormones in Plants and Environment
ISBN: 9048161983 ISBN-13(EAN): 9789048161980
Издательство: Springer
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Цена: 26120.00 р.
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Описание: Therefore, this effort proposes a more holistic approach to the study of plant physiology, in which the plant-soil interactions are discussed, with a profound description of different allelochemicals and their effects on plants growth.

Sterol Biosynthesis Inhibitors and Anti-Feeding Compounds

Автор: T. Kato; W. Kr?mer; K.-H. Kuck; D.M. Norris; H. Sc
Название: Sterol Biosynthesis Inhibitors and Anti-Feeding Compounds
ISBN: 3642697925 ISBN-13(EAN): 9783642697920
Издательство: Springer
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Цена: 18167.00 р.
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Описание: Living organisms are separated from the outside world by their membranes, which perform important roles for maintaining their lives. Sterols are indispensable com- ponents in eukaryotic organisms for stabilizing membranes composed of phospho- lipid bilayers. Most prokaryotic organisms, on the other hand, do not contain sterols in their membranes, although recent studies indicated that the bacterium Methylo- coccus capsulatus produces sterols 1) and many strains of Mycoplasma, bacteria without cell walls, require sterols as an essential growth factor 2). Some bacterial species synthesize hopanoids which are hypothesized to function like st rols in eu- karyotic organisms 3). Significance of ergosterol in fungi has been recognized from the fact that the yeast Saccharomyces cerevisiae requires ergosterol for growth, when cultured in a strictly anaerobic condition "'. l: .lectron microscopic studies showed that membrane structures disappeared in the yeast grown anaerobically without a supplement of ergosterol 5.6), indicating the necessity of ergosterol for membrane biogenesis. Further confirmation of the significant role of ergosterol in the membranes was derived from the studies on polyene antibiotics. In the presence of polyenes such as nystatin, filipin and amphotericin B, fungal cells lose selective permeability of the membranes, since polyenes interact with ergosterol, such that the structure of the fungal membranes is disrupted 7).


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