Chiral Recognition in Separation Methods, Alain Berthod

Автор: Toda Fumio
Название: Enantiomer Separation / Fundamentals and Practical Methods
ISBN: 1402023367 ISBN-13(EAN): 9781402023361
Издательство: Springer
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Описание: Enantiomer Separation is written by several experts working in modern enantiomer separation chemistry who understand the needs of the many scientific and engineering chemists who need a cost-efficient supply of optically active materials of high quality. This book contains the following modern practical methods of enantiomer separation: Inclusion complexation of a racemic compound with a chiral host compound, which gives chiral host-chiral guest inclusion compounds, from which the chiral guest can be obtained. When this separation is combined with distillation technique, for example, enantiomer separation can be accomplished by fractional distillation in the presence of a chiral host compound. This is a modern and "green" procedure of enantiomer separation. These separation methods are described in several chapters of the book. Biological separation methods and "green" methods are covered in two chapters. Enantiomer separation by chromatography on a column containing chiral solid phase is one of the most up-to-date and well known "green" methods of enantiomer separation. Two experts in chromatography have contributed to provide two very important chapters on this method of separation. Practical methods of enantiomer separation are important both in the research laboratory and in industry, especially in the pharmaceutical, fine chemical and electronic industries. Chemists and engineers, as well as students who are working in the field of chiral compounds in universities, institute and industry, will find this book an invaluable resource.

Автор: Weihua Tang; Siu-Choon Ng; Dongping Sun
Название: Modified Cyclodextrins for Chiral Separation
ISBN: 3642376479 ISBN-13(EAN): 9783642376474
Издательство: Springer
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Описание: This book reviews the whole spectrum of neutral and charged cyclodextrins for capillary electrophoresis. It introduces a new family of cyclodextrin-based chiral stationary phases for various chromatographic techniques.

Автор: Ahuja, Satinder
Название: Chiral Separations by Chromatography
ISBN: 0841236313 ISBN-13(EAN): 9780841236318
Издательство: Oxford Academ
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Описание: The primary focus of this book is on developing or selecting suitable chromatographic methods for chiral separations. A large number of examples are given to assist in this process, including thin-layer, gas, HPLC, supercritical fluid, capillary electrophoresis, and membrane separations. It
provides information on stereochemistry, TLC, GLC, and CE separation methods and detection; explores the importance of preparative separations; and illustrates the stereoisomeric composition of chemical compounds of pharmaceutical significance. There is discussion of regulations and requirements as
they apply to the development of pharmaceutical compounds, and a detailed section on HPLC methods.

Автор: Lin, Guo-qiang You, Qi-dong Cheng, Jie-fei
Название: Chiral drugs
ISBN: 0470587202 ISBN-13(EAN): 9780470587201
Издательство: Wiley
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Описание: Presenting an overview of chiral drugs and their impact on the pharmaceutical industry, Chiral Drugs: Chemistry and Biological Action provides an integrated perspective of chiral drugs from concept, synthesis, and pharmaceutical properties.

Автор: w Lough
Название: Chiral Liquid Chromatography
ISBN: 9401068755 ISBN-13(EAN): 9789401068758
Издательство: Springer
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Описание: While working as a chromatographer in the pharmaceutical industry, it became apparent to the editor that there was a pressing need for a comprehensive reference text for analysts working on the resolution of enantiomers by liquid chromatography (LC).

Автор: Rudolf Janoschek
Название: Chirality
ISBN: 3642765718 ISBN-13(EAN): 9783642765711
Издательство: Springer
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Описание: Les hypotheses, n'en deplaise a mon contradicteur, sont l'ame des progres de la science. Louis Pasteur The concept of chirality, established 100 years ago, plays an im- portant role in almost all domains and dimensions of our recent scientific view of life. Chiral properties can be found in fundamen- tal nuclear particles, in molecules, and in the macroscopic world of living nature (plants and animals) and inanimate nature (crystals). In particular, chirality, or more precisely chiral excess, is evident in human beings. For example, the expected symmetry of the hands turns out to be functionally non-existent. Consequently chirality occurs in the technical sphere, where screws are the best-known examples, since most of them are made for right-handed people. Chirality is not confined to static objects but influences processes such as chemical reactions. The occurrence of chiral objects on different dimensional scales has been treated in the past in mutually independent frameworks. There were, however, two remarkable events from which the conclu- sion can be drawn that the appearance of chirality in various fields has a common cause. On the one hand, physicists found evidence that the well-known biomolecular homochirality can be traced back to the chirality of weak bosons. At the same time, on the other hand, the so-called thalidomide tragedy occurred when thalido- mide molecules of a certain chirality, taken by pregnant women, caused deformed children.