Molecular Biology of Mutagens and Carcinogens, Beatrice Singer; D. Grunberger

Автор: Huidong Zhang
Название: DNA Replication - Damage from Environmental Carcinogens
ISBN: 9401772118 ISBN-13(EAN): 9789401772112
Издательство: Springer
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Цена: 7685.00 р.
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Описание: This book reviews the main concepts concerning DNA damage due to environmental carcinogens, the effects of DNA damage on DNA replication using a single DNA polymerase or DNA replisome, and the effects of carcinogens on various cell activities. It also introduces the detailed protocols for bypassing DNA damage. As we know, various environmental carcinogens are produced as a result of industry, agriculture, chemical engineering and vehicle exhaust in our daily life. It has been reported that the environmental carcinogens can be connected to tumors and cancer, directly threatening human health. In this regard, DNA replication is highly susceptible to damage. This book provides graduate students and researchers with an overview of the effects of environmental carcinogens on DNA replication and biological activities in cells. It offers important information for research in the areas of biochemistry, cell biology, medicine, toxicology and public health.

Автор: F.A. Beland; L.G. Cain; J.S. Felton; J.D. Groopman
Название: Chemical Carcinogenesis and Mutagenesis I
ISBN: 3642747779 ISBN-13(EAN): 9783642747779
Издательство: Springer
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Цена: 16979.00 р.
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Описание: I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin- Madison.

Автор: Nohmi, Takehiko
Название: Thresholds of Genotoxic Carcinogens
ISBN: 0128016639 ISBN-13(EAN): 9780128016633
Издательство: Elsevier Science
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Описание: "

Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation" brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold at which these genotoxic carcinogens take action.

The book examines these potential thresholds, describing the potential cancer risks of daily low-level exposure, the mechanisms involved (such as DNA repair, detoxication, translesion DNA synthesis), chemical and statistical methods of analysis, and the ways in which these may be utilized to inform policy. "Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation" is an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation.
Unites an international team of experts to provide a balanced overview of the current opinion on thresholds of genotoxic carcinogensProvides all the information readers need to determine a safe threshold for potential genotoxic carcinogensIncludes information on the mechanisms of genotoxic carcinogens and how these can inform regulationServes as an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation