Описание: Introduction.- Optimal Origin Placement for Minimal Replication Time.- Actively Replicating Domains Randomly Associate into Replication Factories.- Summary and Conclusions.
Автор: Nohmi, Takehiko Название: Thresholds of Genotoxic Carcinogens ISBN: 0128016639 ISBN-13(EAN): 9780128016633 Издательство: Elsevier Science Рейтинг: Цена: 15159.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: "
Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation" brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold at which these genotoxic carcinogens take action.
The book examines these potential thresholds, describing the potential cancer risks of daily low-level exposure, the mechanisms involved (such as DNA repair, detoxication, translesion DNA synthesis), chemical and statistical methods of analysis, and the ways in which these may be utilized to inform policy. "Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation" is an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation. Unites an international team of experts to provide a balanced overview of the current opinion on thresholds of genotoxic carcinogensProvides all the information readers need to determine a safe threshold for potential genotoxic carcinogensIncludes information on the mechanisms of genotoxic carcinogens and how these can inform regulationServes as an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation
Автор: Monika Glinkowska; Lidia Boss; Grzegorz Wegrzyn Название: DNA Replication Control in Microbial Cell Factories ISBN: 3319105329 ISBN-13(EAN): 9783319105321 Издательство: Springer Рейтинг: Цена: 9141.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Introduction.- Coordinating duplication of genetic material with cell growth - current views and old questions.- Structural organization of cellular processes and the regulation of cell cycle.- The link between metabolism and DNA replication.- Transcriptional activation - the unsolved problem.- Activity of DnaA is inhibited by components of translation machinery.- Nucleoid-associated proteins modulate activity of the DnaA initiator.- Interaction of DnaA with acidic components of fluid cellular membrane regulates its nucleotide-bound status and binding to oriC.- Influence of DNA replication on cell structure and function.- Conclusions.
Автор: Beatrice Singer; D. Grunberger Название: Molecular Biology of Mutagens and Carcinogens ISBN: 1461337747 ISBN-13(EAN): 9781461337744 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book originated in numerous Gordon Research Conferences and many other meetings of scientists working in chemistry, biophysics, biochemistry, and biology related to mutagenesis and carcinogenesis.
Название: Initiation of dna replication in eukaryotes ISBN: 3319246941 ISBN-13(EAN): 9783319246949 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: ГЇВїВЅ Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells.
Автор: Mieczyslaw Pokorski Название: Respiratory Carcinogenesis ISBN: 3319169211 ISBN-13(EAN): 9783319169217 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book blends basic and clinical research on respiratory carcinogensis. The focus is on the search for novel molecular markers, derived from easily accessible tissues in clinical settings, such as the serum or bronchoalveolar lavage fluid, which could help diagnose cancer at an early stage and have a prognostic therapeutic value.
Автор: F.A. Beland; L.G. Cain; J.S. Felton; J.D. Groopman Название: Chemical Carcinogenesis and Mutagenesis I ISBN: 3642747779 ISBN-13(EAN): 9783642747779 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin- Madison.
Автор: Lionel A. Poirier Название: Essential Nutrients in Carcinogenesis ISBN: 1461290252 ISBN-13(EAN): 9781461290254 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: For more than 50 years, it has been recognized that diet influences cancer formation both in humans and in experimental animals. Subsequent studies showed that the influence of diet on cancer formation was not only very complex, it also did not appear to playa direct causative role in carcinogenesis.
ООО "Логосфера " Тел:+7(495) 980-12-10 www.logobook.ru
