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Targeted Drug Delivery, Rudolph L. Juliano; K.L. Audus; N. Bodor; R.T. Bor


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Цена: 18284.00р.
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Автор: Rudolph L. Juliano; K.L. Audus; N. Bodor; R.T. Bor
Название:  Targeted Drug Delivery
ISBN: 9783642758645
Издательство: Springer
Классификация:



ISBN-10: 3642758649
Обложка/Формат: Soft cover
Страницы: 364
Вес: 0.58 кг.
Дата издания: 13.12.2011
Серия: Handbook of Experimental Pharmacology
Язык: English
Издание: Softcover reprint of
Иллюстрации: 24 black & white tables, biography
Размер: 234 x 156 x 20
Читательская аудитория: Professional & vocational
Основная тема: Pharmacology/Toxicology
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Targeted drug delivery, that is control of the kinetic behavior, tissue distribution, and subcellular localization of pharmaco- logically active agents, offers an important means for improving the efficacy of a wide variety of drug therapies.


Targeted Therapy of Acute Myeloid Leukemia

Автор: Michael Andreeff
Название: Targeted Therapy of Acute Myeloid Leukemia
ISBN: 1493913921 ISBN-13(EAN): 9781493913923
Издательство: Springer
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Цена: 25155.00 р.
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Описание: This book provides an unprecedented overview of "Targeted Therapies" for acute myeloid leukemias. It aims at an almost comprehensive coverage of the diverse therapeutic strategies that have been developed during the last decade and are now being evaluated in early clinical trials. Paired and authoritative chapters by leading research scientists and clinicians explain basic concepts and clinical translation of topics that include the underlying genetic and proteomic abnormalities of AML, the development of novel nucleoside analogues, the roles of microRNAs, apoptosis regulators Bcl-2 and p53 and of critical cell signaling proteins such as PIM, FLT3, Raf/MEK, PI3K/AKT/mTOR and aurora kinases. Chapters on epigenetic mechanisms, nuclear receptors, cell surface antigens, the hypoxic leukemia microenvironment, stem cells and leukemia metabolism provide insights into leukemia cell vulnerabilities. Cell therapies utilizing T-, NK- and mesenchymal stem cells and progress in hematopoietic transplantation strategies round up this overview of the multi-dimensional therapeutic landscape in which leukemia specialists develop treatment strategies that are expected to make "leukemia history" in the near future.

MicroRNA Targeted Cancer Therapy

Автор: Fazlul H. Sarkar
Название: MicroRNA Targeted Cancer Therapy
ISBN: 3319051334 ISBN-13(EAN): 9783319051338
Издательство: Springer
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Цена: 23508.00 р.
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Описание: The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs) and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass.

Cancer Targeted Drug Delivery

Автор: You Han Bae; Randall J. Mrsny; Kinam Park
Название: Cancer Targeted Drug Delivery
ISBN: 1461478758 ISBN-13(EAN): 9781461478751
Издательство: Springer
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Цена: 30039.00 р.
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Описание: This volume provides information related to the difficulties in treating cancers through targeted drug delivery. It examines our current understanding of cancer biology as well as potential technologies that may achieve enhanced drug delivery to tumors.

Resistance to Targeted ABC Transporters in Cancer

Автор: Thomas Efferth
Название: Resistance to Targeted ABC Transporters in Cancer
ISBN: 3319098004 ISBN-13(EAN): 9783319098005
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This critical review volume explores the theme of ABC transporters in the context of basic cancer research and its role in drug-resistant tumors. The chapters provided complement basic research by including investigations from translational applications to clinical oncology. The development of resistance is a major obstacle in cancer chemotherapy and the field has been moving rapidly in terms of determining the mechanisms for blocking ABC transporter-mediated drug efflux by specific inhibitors and thereby overcoming multidrug resistance. The volume covers these issues in careful detail. Additional topics include the relevance of ABC transporters in resistance to novel and established anticancer drugs and prognosis of patients to compounds, compounds used in photodynamic therapy, tyrosine kinase inhibitors and others. Furthermore, the potential of radiopharmaceuticals for diagnosis of multidrug-resistant tumors and of nanotechnology to combat drug-resistant tumors is also discussed.


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