Michael Andreeff Targeted Therapy of Acute Myeloid Leukemia 9781493913923

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Автор: Michael Andreeff
Название: Targeted Therapy of Acute Myeloid Leukemia
ISBN: 9781493913923
Издательство: Springer
Классификация:

Онкология

Гематология

Фармакология

ISBN-10: 1493913921
Обложка/Формат: Hardcover
Страницы: 826
Вес: 1.38 кг.
Дата издания: 21.11.2014
Серия: Current Cancer Research
Язык: English
Издание: 2015 ed.
Иллюстрации: 24 tables, black and white; 46 illustrations, color; 16 illustrations, black and white; xix, 826 p. 62 illus., 46 illus. in color.
Размер: 239 x 164 x 47
Читательская аудитория: Professional & vocational
Основная тема: Cancer Research
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This book provides an unprecedented overview of Targeted Therapies for acute myeloid leukemias. It aims at an almost comprehensive coverage of the diverse therapeutic strategies that have been developed during the last decade and are now being evaluated in early clinical trials. Paired and authoritative chapters by leading research scientists and clinicians explain basic concepts and clinical translation of topics that include the underlying genetic and proteomic abnormalities of AML, the development of novel nucleoside analogues, the roles of microRNAs, apoptosis regulators Bcl-2 and p53 and of critical cell signaling proteins such as PIM, FLT3, Raf/MEK, PI3K/AKT/mTOR and aurora kinases. Chapters on epigenetic mechanisms, nuclear receptors, cell surface antigens, the hypoxic leukemia microenvironment, stem cells and leukemia metabolism provide insights into leukemia cell vulnerabilities. Cell therapies utilizing T-, NK- and mesenchymal stem cells and progress in hematopoietic transplantation strategies round up this overview of the multi-dimensional therapeutic landscape in which leukemia specialists develop treatment strategies that are expected to make leukemia history in the near future.
Дополнительное описание: Introduction/Perspective.- Genetics and Classification of Acute Myeloid Leukemia.- Proteomics of AML to guide Selection of Therapy.- Roles of Apoptosis Regulating Bcl-2-Family Genes in AML.- Bcl-2 family: Translational aspects.- IAP Family and Proteins as

Targeted Therapy of Acute Myeloid Leukemia, Michael Andreeff