Myeloid-derived suppressor cells and cancer, Escors, David Talmadge, James E. Breckpot, Karine Van Ginderachter, Jo A. Kochan, Grazyna

Автор: Gerard P. Zambetti
Название: The p53 Tumor Suppressor Pathway and Cancer
ISBN: 1489998799 ISBN-13(EAN): 9781489998798
Издательство: Springer
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Цена: 26120.00 р.
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Описание: The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. Fueling the concept of p53 acting as a transforming factor, p53 expression was markedly elevated in various transformed and tumorigenic cell lines when compared to normal cells.

Автор: David E. Fisher
Название: Tumor Suppressor Genes in Human Cancer
ISBN: 161737198X ISBN-13(EAN): 9781617371981
Издательство: Springer
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Цена: 34799.00 р.
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Описание: Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.

Автор: Dennis Eden
Название: Today and Tomorrow of Tumor Suppressor Gene
ISBN: 1632424053 ISBN-13(EAN): 9781632424051
Издательство: Неизвестно
Цена: 20967.00 р.
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Автор: Dennis Eden
Название: Tumor Suppressor Genes Handbook
ISBN: 1632424126 ISBN-13(EAN): 9781632424129
Издательство: Неизвестно
Цена: 27404.00 р.
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Автор: Wafik S. El-Deiry
Название: Tumor Suppressor Genes
ISBN: 1489939148 ISBN-13(EAN): 9781489939142
Издательство: Springer
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Цена: 15372.00 р.
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Описание: It has become clear that tumors result from excessive cell proliferation and a corresponding reduction in cell death caused by the successive accumulation of mutations in key regulatory target genes over time.

Автор: Tapas Mukhopadhyay; Steven A. Maxwell; Jack A. Rot
Название: p53 Suppressor Gene
ISBN: 3662222779 ISBN-13(EAN): 9783662222775
Издательство: Springer
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Цена: 15672.00 р.
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Описание: This book is about the p53 gene, one of the most frequently mutated or deleted genes in human cancers. The p53 protein is a transcription factor that can repress or activate promoters containing one of three p53 DNA-binding motifs. Replacement of the p53 function or restoration of the p53 biochemical pathway is a focus of gene therapy.

Автор: Michael Andreeff
Название: Targeted Therapy of Acute Myeloid Leukemia
ISBN: 1493913921 ISBN-13(EAN): 9781493913923
Издательство: Springer
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Цена: 25155.00 р.
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Описание: This book provides an unprecedented overview of "Targeted Therapies" for acute myeloid leukemias. It aims at an almost comprehensive coverage of the diverse therapeutic strategies that have been developed during the last decade and are now being evaluated in early clinical trials. Paired and authoritative chapters by leading research scientists and clinicians explain basic concepts and clinical translation of topics that include the underlying genetic and proteomic abnormalities of AML, the development of novel nucleoside analogues, the roles of microRNAs, apoptosis regulators Bcl-2 and p53 and of critical cell signaling proteins such as PIM, FLT3, Raf/MEK, PI3K/AKT/mTOR and aurora kinases. Chapters on epigenetic mechanisms, nuclear receptors, cell surface antigens, the hypoxic leukemia microenvironment, stem cells and leukemia metabolism provide insights into leukemia cell vulnerabilities. Cell therapies utilizing T-, NK- and mesenchymal stem cells and progress in hematopoietic transplantation strategies round up this overview of the multi-dimensional therapeutic landscape in which leukemia specialists develop treatment strategies that are expected to make "leukemia history" in the near future.

Автор: Carella
Название: Chronic Myeloid Leukaemia
ISBN: 185317890X ISBN-13(EAN): 9781853178900
Издательство: Informa
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Цена: 15886.00 р.
Наличие на складе: Нет в наличии.

Описание: Drawing on the expertise of an international team of experts in chronic myeloid leukemia, this book provides insight into the latest advances and the implications those developments have for management of the disease. The editors and their panel of contributors explore many topics, including a review of molecular and cellular biology, a discussion of conventional chemotherapy and interferon therapy, and recent developments in allografting and autografting. The reader gains not only an incisive view of the biological structure of the disease, but applications of that biology to treatment modalities. The book emphasizes treatment strategies and is a guide to complex treatment options.