p53 Suppressor Gene, Tapas Mukhopadhyay; Steven A. Maxwell; Jack A. Rot

Автор: Escors, David Talmadge, James E. Breckpot, Karine Van Ginderachter, Jo A. Kochan, Grazyna
Название: Myeloid-derived suppressor cells and cancer
ISBN: 3319268198 ISBN-13(EAN): 9783319268194
Издательство: Springer
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Цена: 9141.00 р.
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Описание: The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting.

Автор: Dmitry I. Gabrilovich; Arthur Andrew Hurwitz
Название: Tumor-Induced Immune Suppression
ISBN: 1489980555 ISBN-13(EAN): 9781489980557
Издательство: Springer
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Цена: 28734.00 р.
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Описание: Tumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer and therapeutic approaches to their correction.

Автор: Wiman Klas G., Hainaut Pierre
Название: 25 Years of P53 Research
ISBN: 1402065647 ISBN-13(EAN): 9781402065644
Издательство: Springer
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Цена: 15672.00 р.
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Описание: The discovery of p53 in 1979 marks the beginning of a most fascinating era of modern cancer research and molecular biology. This book provides insights into the progress of the p53 field and the prospects for better cancer diagnosis and therapy. It is of interest to everybody working in cancer research, clinical oncology, and molecular biology.

Автор: Gerard P. Zambetti
Название: The p53 Tumor Suppressor Pathway and Cancer
ISBN: 1489998799 ISBN-13(EAN): 9781489998798
Издательство: Springer
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Цена: 26120.00 р.
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Описание: The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. Fueling the concept of p53 acting as a transforming factor, p53 expression was markedly elevated in various transformed and tumorigenic cell lines when compared to normal cells.

Автор: Swati Palit Deb; Sumitra Deb
Название: Mutant p53 and MDM2 in Cancer
ISBN: 9401792100 ISBN-13(EAN): 9789401792103
Издательство: Springer
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Цена: 22359.00 р.
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Описание:

p53 and hereditary cancer.- Alterations of p63 and p73 in human cancers.- Cooperation of p53 mutations with other oncogenic alterations in cancer.- p53 mutations and how mutations affect transcription.- Transcriptional regulation by mutant p53 and oncogenesis.- p53 mutation in the genesis of metastasis.- Structural studies on mechanisms to activate mutant p53.- Mutant p53 and the response to chemotherapy and radiation.- The p53-MDM2 loop: a critical juncture of stress response.- Mechanisms of mutant p53 stabilization in cancer.- Crosstalk between Mdm2, p53 and HIF-1α distinct responses to oxygen stress and implications for tumour hypoxia.- MDM2 overexpression, activation of signaling networks, and cell proliferation.- p53-independent effects of MDM2.- Splice variants of MDM2 in oncogenesis.- MDM2 and MDMX involvement in human cancer.- Targeting the p53-MDM2- MDMX loop for cancer therapy.- Involvement of p53 in the repair of DNA double strand breaks: Multifaceted roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ).- The role of tumor suppressor p53 in the antioxidant defense and metabolism.- Lung cancer stem cells, p53 mutations and MDM2.

Автор: Hiroshi Maruta
Название: Tumor Suppressing Viruses, Genes, and Drugs,
ISBN: 0124762492 ISBN-13(EAN): 9780124762497
Издательство: Elsevier Science
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Цена: 16001.00 р.
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Описание: There has been increased focus on alternative treatments for cancer. This text presents the various cancer therapeutics that are being used or developed as a result of our knowledge about oncogenes, tumour suppressor genes and viral and non-viral replication.